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- 저자 : Choong-Ki Kim (검색결과 871 건)
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Bing Chun Yan,In Hye Kim,Joon Ha Park,Ji Hyeon Ahn,Jeong-Hwi Cho,Bai Hui Chen,Jae-Chul Lee,Jung Hoon Choi,Ki-Yeon Yoo,Choong Hyun Lee,Jun Hwi Cho,Jong-Dai Kim,Moo-Ho Won 한국실험동물학회 2013 Laboratory Animal Research Vol.29 No.3
In the present study, we investigated the effect of Tetaus toxin (TeT) on cell proliferation and neuroblast differentiation using specific markers: 5-bromo-2-deoxyuridine (BrdU) as an exogenous marker for cell proliferation, Ki-67 as an endogenous marker for cell proliferation and doublecortin (DCX) as a marker for neuroblasts in the mouse hippocampal dentate gyrus (DG) after TeT treatment. Mice were intraperitoneally administered 2.5 and 10 ng/kg TeT and sacrificed 15 days after the treatment. In both the TeT-treated groups, no neuronal death occurred in any layers of the DG using neuronal nuclei (NeuN, a neuron nuclei maker) and Fluoro-Jade B (F-J B, a high-affinity fluorescent marker for the localization of neuronal degeneration). In addition, no significant change in glial activation in both the 2.5 and 10 ng/kg TeT-treated-groups was found by GFAP (a marker for astrocytes) and Iba-1 (a marker for microglia) immunohistochemistry. However, in the 2.5 ng/kg TeT-treated-group, the mean number of BrdU, Ki-67 and DCX immunoreactive cells, respectively, were apparently decreased compared to the control group, and the mean number of each in the 10 ng/kg TeT-treated-group was much more decreased. In addition, processes of DCX-immunoreactive cells, which projected into the molecular layer, were short compared to those in the control group. In brief, our present results show that low dosage (10 ng/kg) TeT treatment apparently decreased cell proliferation and neuroblast differentiation in the mouse hippocampal DG without distinct gliosis as well as any loss of adult neurons.
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YOO, Dae Young,NAM, YoonYi,KIM, Woosuk,YOO, Ki-Yeon,PARK, Jaeil,LEE, Choong Hyun,CHOI, Jung Hoon,YOON, Yeo Sung,KIM, Dong-Woo,WON, Moo-Ho,HWANG, In Koo Japanese Society of Veterinary Science 2011 The Journal of veterinary medical science Vol.73 No.1
<P><I>Ginkgo biloba </I>leaf extract (Gb) has been known to improve blood flow and preclude the tissue from free radical damage. Effects of Gb were examined by using Ki67, a specific proliferative marker for cellular proliferation, and doublecortin (DCX), a marker for immature neurons, indicating degree of neuroblast differentiation in the hippocampal dentate gyrus (DG) of adult C57BL/6 mice. The mice were fed with Gb at 40 and 100 mg/kg once daily for 28 days. The increase of Ki67- and DCX-immunoreactive cells in the DG was increased in a dose-dependent manner. Especially, the group having 100 mg/kg Gb showed a significant increase of DCX-immunoreactive neuroblasts with well-developed tertiary dendrites. Expression of DCX protein in the Gb groups was also significantly increased upon compared with the vehicle group. The results suggested that repeated intake of Gb would enhance cell proliferation and neuroblast differentiation in the mouse DG.</P>
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Yoo, Dae Young,Shin, Bich Na,Kim, In Hye,Kim, Woosuk,Kim, Dae Won,Yoo, Ki-Yeon,Choi, Jung Hoon,Lee, Choong Hyun,Yoon, Yeo Sung,Choi, Soo Young,Won, Moo-Ho,Hwang, In Koo Kluwer Academic/Plenum Publishers 2012 Neurochem Res Vol.37 No.2
<P>Oxidative stress is one of the most important factors in reducing adult hippocampal neurogenesis in the adult brain. In this study, we observed the effects of Cu,Zn-superoxide dismutase (SOD1) on lipid peroxidation, cell proliferation, and neuroblast differentiation in the mouse dentate gyrus using malondialdehyde (MDA), Ki67, and doublecortin (DCX), respectively. We constructed an expression vector, PEP-1, fused PEP-1 with SOD1, and generated PEP-1-SOD1 fusion protein. We administered PEP-1 and 100 or 500 관g PEP-1-SOD1 intraperitoneally once a day for 3 weeks and sacrificed at 30 min after the last administrations. PEP-1 administration did not change the MDA levels compared to those in the vehicle-treated group, while PEP-1-SOD1 treatment significantly reduced MDA levels compared to the vehicle-treated group. In the PEP-1-treated group, the number of Ki67-positive nuclei was similar to that in the vehicle-treated group. In the 100 관g PEP-1-SOD1-treated group, the number of Ki67-positive nuclei was slightly decreased; however, in the 500 관g PEP-1-SOD1-treated group, Ki67-positive nuclei were decreased to 78.5% of the vehicle-treated group. The number of DCX-positive neuroblasts in the PEP-1-treated group was similar to that in the vehicle-treated group. However, the arborization of DCX-positive neuroblasts was significantly decreased in both the 100 and 500 관g PEP-1-SOD1-treated groups compared to that in the vehicle-treated group. The number of DCX-positive neuroblasts with tertiary dendrites was markedly decreased in the 500 관g PEP-1-SOD1-treated group. These results suggest that a SOD1 supplement to healthy mice may not be necessary to modulate cell proliferation and neuroblast differentiation in the dentate gyrus.</P>
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平生敎育에 비추어 본 中學校의 生涯敎育 : A Perspective of Life Long Education
金忠起 건국대학교 1981 學術誌 Vol.25 No.1
Today's youth live in a stimulating climate of change and challenge. With a rapid technological advancement and expansion of knowledge has come a deep concern for humanism and individuality. There is a need to refocus our thinking and to establish new priorities in education. All students need the opportunity to develop an awareness of their own potential, a sense of dignity and pride in accomplishment, and the confidence to move forward to their goals. Education facinates the citizen and the scholar alike in the modern era, as it grows in importance but retreats from the view of the amateur. As a society undergoes industrialization and modernization, it's instruction of the young becomes extensively differentiated, internally complex, and elaborately connected with other features of society. Education becomes more necessary for the economy and linked closely to it as a major mediator between man-power demand and labor supply. Occupational competence, general and specific, is increasingly certified by schooling, and achievement is thereby prefigured, as labor shifts from manual to mental and from low to high degree of skill. In an interdependent technical society, the development of competence to produce a fair share of commodities and services is a major objective of any realistic educational system. Emerging concepts of "career education" can be viewed as one basic part of the process by which an educational system pursues all of these objectives. Clearly, work and the products of work help make life satisfactory. Useful work can also help fulfill a major portion of their civic obligations for these reasons, career education has potential for becoming more than "catch word" of the latest commission of education. Dr. Sidney p. Marland proclaimed the importance of career education at the conference of highschool principals in Houston, Texas, 1972, for the first time. He has asserted that : All education is career education, or should be. All our efforts as educators must be bent on preparing students either to become properly useful employed immediately upon graduation from high school or to grow to further formal education. The term "career education" represents a synthesis and blend of many concepts and elements available at some point. However, the intent and the implementation tactics so far apparent are to bring these concepts and elements into a new and systematic interrelationship among vocational education, vocational guidance, career development and other elements of the educational and community networks of which they are a part. When the concept of career education began to take form, there was considerable confusion over the role of preparation for work in such an educational plan. A little more than 10 years ago, no voice was heard criticizing or praising career education. The situation is different now. The role and objectives of educational system are questioned and criticized because social and economic forces have demanded a change in presocietive and attitude. Changing conditions in our society have created and entirely new environment : new aspirations, new jobs, new careers, and new national objectives. Advances in science and technology, have created imbalances in the nation's social, economic, and educational institutions. Science and technology have changed the nature of human problems for a majority of individuals. Preparation for work, both in the school and on the job, is a vital part of career education. If it is not available in sufficient quantity, or if it is designated in ways which fail to increase student options, or if it is restricted only to certain prestigious occupations, many students will suffer. Therefore, a primary motive for developing career education is to resolve the problem of the large number of students who are graduating or ill-equipped to cope with the complexities of the world of work. The concept of career education is not a new or revolutionary idea; rather, it has evolved as a result of (1) redirected educational goals, (2) educational legislation, and (3) research in human development. Career education has not been precisely defined, but one concept sees it as a systematic attempt to increase the career options open to all students and the facilitate more rational and valid career planning and preparation. Career education is viewed as a developmental process which capacitates individuals for their several life roles : economic, community, home, avocational, religious, and aesthetic. It begins in Kindergarten, continues through a student's schooling to grade twelve, and extends into his adult years. Every student progresses from awareness, orientation to exploration and skill development in a continuous advancement to word his individual careers. Currently, there are four alternative ways of delivering or facilitating career education goals-school-based, employer-based, home community-based, and residential-based models. A successful program depends in large measure on the quality of leadership. Many factors are considered in undertaking this major redirection of school system. In summary, the needs for career education are urgent and obvious in this country. Government authority already set up item of life-long education in the constitution to build up education for life long. This means also career education. In my judgement, career education builds on a sound philosophical and theoretical framework. In the broader context, it may well provide the vihicle fur revitalizing the educational enterprise and reestablishing its relevance and credibility with society, Further, if career education is successful in delivering on its promise, we can look to diverting resources from present investments in programs of unemployment, welfare, and correction. As educators, we must confront it, think it through, consider it and evaluate it so that career education can more effectively keep it's promise of fully capacitating individuals for their multiple life roles.
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전류에 대한 오개념 교정을 위한 CAI 프로그램 개발 및 적용
김기웅,최춘태,이성근,이충일 순천대학교 과학교육연구소 2000 科學과 敎育 Vol.8 No.-
The purpose of this study is as follows: (1) We develope a CAI(computer assisted instruction) program for misconception correction on electronic current. (2) To study leaning effects of CAI program, we apply it to relevant grades of junior high school students and investigate degree of the science achievement. The findings of this study are as follows : Many students had misconceptions about electric current such as current consumption idea, current distribution idea, current independent of resistance idea. CAI classes applied with individual learning were effective to correct the misconception. Especially, they brought about big difference in the achievement of correction for current distribution idea.
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단무지 공장에서 발생한 질식 사고의 원인과 방사선학적 소견: 중례보고 및 가스분석 결과
박충기,김만구,김흥철,안범규,박만수,황우철,최철순,강익원 江原大學校 附設 環境硏究所 1994 環境硏究 Vol.11 No.-
목 적:단무지 공장에서 질식사고를 일으켰던 가스의 종류를 알아내고, 이러한 가스중독의 방서선학적 소견을 소개하기 위하여 본 연구를 하였다. 대상 및 방법:단무지 공장에서 발생한 질식 사고자 3예중 생존자 1예를 대상으로 단순흥부X-선검사와 CT 소견을 분석하였으며, 가스의 종류를 알아내기 위하여 단무지를 유리병에 넣어 발생된 가스를 가스크로마토그래픽을 이용하여 분석하였다. 결 과:단무지 공장에서 발생한 질식사고자중 생존한 1명의 방사선학적 검사에서 신속히 호전되는 폐경결(consolidation)을 볼 수 있었으며 이는 폐부종의 소견임을 알 수 있었다. 협기성 상태에서 단무지를 담은 유리병의 상층부 가스를 실험 분석한 결과 이산화탄소, 에칠알코올이 다량으로 검출되었으나 독성가스는 주로 황화수소이였다. 결 론:단무지 공장의 질식 사고자에서 폐방사선학적 소견은 폐경결을 보이는 폐부증으로서 이는 실험을 통해 단무지에서 발생되는 유독가스인 황화수소 때문임을 입증하였다. Purpose: To identify the main toxic gas released from salted radish in rice bran(Dan-M-Ji) and to introduce the radiological findings of the patient who was exposed to the gas. Materials and Methods: Chest radiographs and CT scans of one survivor among three men who were exposed to the gas from Dan-Mu-Ji were reviewed. Gas obtained from the closed bottle containing Dan-Mu-Ji was analized by using the gas chromatography. Results: The radiographlc examinations of the survivor were suggestive of pulmonary edema with it's rapidly improving consolidations in both lung. The headapace gas within the bottle containing Dan-Mu-Ji was mainly composed with carbon dioxide, ethyl alcohol and hydrogen sulfide, of which hydrogen sulfide was considered the main toxic gas released. Conclusion: Under the anaerobic condition, Dan-Mu-Ji released toxic hydrogen sulfide. Inhalation of hydrogen sulfide might produce non-cardiogenic pulmonary edema.
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金忠起 建國大學校 敎育硏究所 1978 論文集 Vol.3 No.-
A primary motive for developing career education is to resolve the problem of the large number of students who are graduating or leaving school and are unable or ill-equipped to cope with complexities of the world of work. This situation is compounded by a fragmented, disjointed, and uncoordinated educational system which dose not parallel the lifelong needs of people for career development. The concept of career education in not a new or revolutionary idea; rather it has evolved as a result of (1) redirected educational goals, (2) educational legislation, and (3) reserch in human development. Career education has not been precisely defined, but one concept see it as a systematic attempt to increase the career options open to all students and to facilitate more rational and valid career planning and preparation. Career education is viewed as a developmental process which capacitates individuals for their several life roles: economic, community, home, avocational, religious, and aesthe-tic. It begins in Kindergarten, continues through a student's schooling to grade twelve, and extends into his adult years, Every student progresses from awareness and orientation to exploration and skill development in a continuous advancement to ward his individual career. Currently, there are four alternative ways of delivering or facilitating career educa-tion goals-school-based, employer-based, home/community-based, and residential-based model, A successful program depends in large measure on the quality of leadership career education provides a viable vehicle for relating to diverse community groups and interests.
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김충기,박인숙 건국대학교 교육연구소 2000 論文集 Vol.24 No.-
The Human being by nature is bad by according to Xun-zi, Chinese scholar, and he suggested that the theory of changing behavior was originated from goodness of personality to the artificiality. According to the story of Xun-zi, he emphasized the importance of environment because environment changes the human nature by artificiality. Xun-zi in his writing, "the encouragement of learning", said that this factor of environment called learning. He indicated the importance of learning and suggested five method of Teaching to be considered in the process of learning. First, learning should have an explicit purpose. Second, he emphasized the accumulation of process of learning. Third, he indicated the consistant mind to the process of learn. Fourth, he insisted on the complete knowledge in the process of learning. Fifth, he suggested that you should utilize the fact of learning. The method of teaching in Xun-Zi was to be considered in the modern education as his foudamental thought to be independent of human being. His main thought is called that of human respectation
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