http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Choi, Minkyu,Furlong, Edward T.,Werner, Stephen L.,Pait, Anthony S.,Lee, In-Seok,Choi, Hee-Gu 한국해양학회 2014 Ocean science journal Vol.49 No.3
Concerns have emerged regarding the presence of human-use pharmaceuticals in aquatic environments. We investigated the status of contamination by 29 human-use pharmaceuticals as well as wastewater indicator compounds, fecal sterols and the synthetic endocrine disruptor nonylphenol, in marine sediments from Masan Bay, one of the most contaminated bays in Korea as a result of untreated and/or treated sewage. Among the 29 pharmaceuticals determined, 10 including antacid, analgesic, antibiotic, and antipruritic compounds, and metabolites of caffeine and nicotine were detected in all sediment samples. Cimetidine, acetaminophen, and 1,7-dimethylxanthine were the most frequently detected pharmaceuticals (frequency > 50%), and at high concentrations. The highest concentrations and detection frequencies were at stations located close to wastewater treatment plant (WWTP) outfalls and at the river mouth. The spatial distributions of pharmaceutical were significantly correlated with those of wastewater compounds. These results indicate that occurrence of the pharmaceuticals in marine environments is likely associated with direct sewage inputs, such as WWTP effluents and with other sewage-influenced sources, such as river discharge.
Choi, Eunyoung,Han, Cecil,Park, Inju,Lee, Boyeon,Jin, Sora,Choi, Heejin,Kim, Do Han,Park, Zee Yong,Eddy, Edward M,Cho, Chunghee American Society for Biochemistry and Molecular Bi 2008 The Journal of biological chemistry Vol.283 No.50
<P>To determine the mechanisms of spermatogenesis, it is essential to identify and characterize germ cell-specific genes. Here we describe a protein encoded by a novel germ cell-specific gene, Mm.290718/ZFP541, identified from the mouse spermatocyte UniGene library. The protein contains specific motifs and domains potentially involved in DNA binding and chromatin reorganization. An antibody against Mm.290718/ZFP541 revealed the existence of the protein in testicular spermatogenic cells (159 kDa) but not testicular and mature sperm. Immunostaining analysis of cells at various stages of spermatogenesis consistently showed that the protein is present in spermatocytes and round spermatids only. Transfection assays and immunofluorescence studies indicate that the protein is localized specifically in the nucleus. Proteomic analyses performed to explore the functional characteristics of Mm.290718/ZFP541 showed that the protein forms a unique complex. Other major components of the complex included histone deacetylase 1 (HDAC1) and heat-shock protein A2. Disappearance of Mm.290718/ZFP541 was highly correlated with hyperacetylation in spermatids during spermatogenesis, and specific domains of the protein were involved in the regulation of interactions and nuclear localization of HDAC1. Furthermore, we found that premature hyperacetylation, induced by an HDAC inhibitor, is associated with an alteration in the integrity of Mm.290718/ZFP541 in spermatogenic cells. Our results collectively suggest that the Mm.290718/ZFP541 complex is implicated in chromatin remodeling during spermatogenesis, and we provide further information on the previously unknown molecular mechanism. Consequently, we re-designate Mm.290718/ZFP541 as 'SHIP1' representing spermatogenic cell HDAC-interacting protein 1.</P>
The necessity of bioanalytical tools for advancing water and sediment quality assessment
Kolodziej, Edward P.,Choi, Kyungho,Marfil-Vega, Ruth,Brooks, Bryan W. The Royal Society of Chemistry 2017 Environmental science Vol.19 No.9
<P>Guest editors Edward Kolodziej, Kyungho Choi, Ruth Marfil-Vega and Bryan Brooks introduce the “Bioanalytical tools for water and sediment quality assessment” themed issue of <I>Environmental Science: Processes & Impacts</I>.</P>
Edwards, H.D.,Shelver, W.L.,Choi, S.,Nisbet, D.J.,Krueger, N.A.,Anderson, R.C.,Smith, S.B. Applied Science Publishers 2017 Food chemistry Vol.218 No.-
Lipolysis and biohydrogenation in ruminal animals promote the accumulation of saturated fatty acids in their meat and milk. Antibodies were generated against key ruminal lipase contributors Anaerovibrio lipolyticus, Butyrivibrio fibrisolvens, Propionibacterium avidum and acnes. An anti-Pseudomonas lipase antibody was generated to determine if an antibody against a purified protein would be more effective. Each bacterium was cultured and assayed without or with increasing levels of each antibody. Butyrivibrio fibrisolvens H17C also participates in biohydrogenation and therefore the antibody was tested to determine if it could effectively reduce biohydrogenation. Butyrivibrio fibrisolvens was assayed without and with the anti-B. fibrisolvens antibody and linoleic or α-linolenic acid. All antibodies were effective at reducing lipolysis with the anti-Pseudomonas lipase averaging a 78% reduction. The anti-B. fibrisolvens showed a tendency for a reduction (P=0.0713) in biohydrogenation products of α-linolenic acid. Results demonstrate that lipolysis and biohydrogenation can be immunologically inhibited in vitro.
Definition and classification of fault damage zones: A review and a new methodological approach
Choi, J.H.,Edwards, P.,Ko, K.,Kim, Y.S. Elsevier Pub. Co 2016 Earth-science reviews Vol.152 No.-
<P>Although the widths of fault damage zones commonly show a positive correlation with displacements, these relationships also show a somewhat scattered distribution. We believe that one of the fundamental reasons for this problem is strongly related to subjective definitions and inconsistent uses of the term 'damage zone'. Thus, firstly we classify damage zones into along-fault, around-tip and cross-fault damage zones based on descriptive views of an arbitrary fault exposure as well as their tridimensional locations around a segmented fault system. Secondly, we propose an advanced field technique and data acquisition method to more accurately define a damage zone using the distribution of cumulative fracture frequency. We tested this method on new field and borehole observations as well as previously published data to identify damage zone boundaries, and express them as a change in slope gradients of the cumulative distribution of deformation structures. The results show how this slope change can be a useful criterion in accurately defining the width of damage zones and some internal properties of fault zones. We argue that this damage zone classification and definition method should be adopted and used to prevent discrepancies in field data. This will help us to gain a better understanding of fault damage zone properties and their scaling with fault displacement. (C) 2015 Elsevier B.V. All rights reserved.</P>