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- 저자 : Charoenchai Laksana (검색결과 2 건)
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Jirapornchai Suksaeree,Chaowalit Monton,Laksana Charoenchai,Natawat Chankana 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.4
This work aimed to apply the Design of Experiments (DOE) approach in microwave-assisted drying of Prasakanphlu (PSKP) herbal granules. Furthermore, DOE was applied in the formulation development of PSKP tablets. The 32 full factorial design consisted of two factors (i.e., microwave power and microwave time) and two responses (i.e., moisture content and eugenol content) that were used for optimized microwave-assisted drying of PSKP granules. The optimal condition was microwave power of 300 W for 15 min. This condition was used to dry the wet granules of PSKP for optimization of tablet formulation. The Box–Behnken design was applied in the formulation development of PSKP tablets; three factors (i.e., compression force, amount of polyvinyl pyrrolidone K30, and amount of sodium starch glycolate) and four responses (i.e., tablet thickness, hardness, friability, and disintegration time) were included in the design. Results showed that the optimal parameters were compression force of 1500 psi, 4.5% polyvinyl pyrrolidone K30, and 2% sodium starch glycolate. Furthermore, rapid dissolution of the optimal tablets was found. In conclusion, the work succeeded in applying DOE for PSKP granule drying by microwave and formulation development of PSKP tablets with desired properties.
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Monton Chaowalit,Settharaksa Sukanya,Suksaeree Jirapornchai,Chankana Natawat,Charoenchai Laksana 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.2
The Trisattakula herbal recipe has been used for a long time for the treatment of the symptom of the gastrointestinal tract. Based on the plant compositions, it exhibits antibacterial activity. This work sought to optimize the mass ratios of plant compositions of Trisattakula recipe (equal mass ratios of dried seeds of Nigella sativa L., dried fruits of Coriandrum sativum L., and fresh rhizomes of Zingiber officinale Roscoe) to maximize the anti-Staphylococcus aureus and anti-S. epidermidis activities. The simplex lattice design was applied in the optimization process. Results showed that dried seeds of N. sativa alone gave the highest extraction yield, and the extract of dried seeds of N. sativa alone exhibited the most potent antibacterial activity. The ethanolic extract of dried seeds of N. sativa was further used as an active ingredient of film-forming polymeric solution (FFPS). The three film-forming agents, including hydroxypropyl methylcellulose E5, xanthan gum, and Eudragit ® RL 30D, were used. However, 5% hydroxypropyl methylcellulose E5 blended 0.5% xanthan gum FFPS system containing 9.2% N. sativa extract was the best formulation. It showed good antibacterial activity against both S. aureus and S. epidermidis. The release of thymoquinone determined using validated high-performance liquid chromatography approached the Korsmeyer-Peppas model. In summary, the FFPS containing N. sativa extract could be used as an alternative antibacterial product for the treatment of skin infection caused by the two pathogens: S. aureus and S. epidermidis.
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