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        Aligned nanofibrous collagen membranes from fish swim bladder as a tough and acid-resistant suture for pH-regulated stomach perforation and tendon rupture

        Zhaohui Luan,Shuang Liu,Wei Wang,Kaige Xu,Shaosong Ye,Ruijue Dan,Hong Zhang,Zhenzhen Shu,Tongchuan Wang,Chaoqiang Fan,Malcolm Xing,Shiming Yang 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4

        Background: Wound closure in the complex body environment places higher requirements on suture’s mechanical and biological performance. In the scenario of frequent mechanical gastric motility and extremely low pH, single functional sutures have limitations in dealing with stomach bleeding trauma where the normal healing will get deteriorated in acid. It necessitates to advance suture, which can regulate wounds, resist acid and intelligently sense stomach pH. Methods: Based on fish swim bladder, a double-stranded drug-loaded suture was fabricated. Its cytotoxicity, histocompatibility, mechanical properties, acid resistance and multiple functions were verified. Also, suture’s performance suturing gastric wounds and Achilles tendon was verified in an in vivo model. Results: By investigating the swim bladder’s multi-scale structure, the aligned tough collagen fibrous membrane can resist high hydrostatic pressure. We report that the multi-functional sutures on the twisted and aligned collagen fibers have acid resistance and low tissue reaction. Working with an implantable “capsule robot”, the smart suture can inhibit gastric acid secretion, curb the prolonged stomach bleeding and monitor real-time pH changes in rabbits and pigs. The suture can promote stomach healing and is strong enough to stitch the fractured Achilles tendon. Conclusions: As a drug-loaded absorbable suture, the suture shows excellent performance and good application prospect in clinical work.

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        Microstructure Change of Nanosilica-Cement Composites Partially Exposed to Sulfate Attack

        Qian Huang,Liang Zhao,Chenggong Zhao,Dongsheng Liu,Chaoqiang Wang 한국콘크리트학회 2020 International Journal of Concrete Structures and M Vol.14 No.3

        The deterioration of cement composites containing nanosilica partially exposed to sulfate attack was studied, and the microstructure change of the composites was analysed by a scanning electron microscope (SEM), energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD). The results showed that nanosilica-cement composites had better sulfate resistance compared to plain cement composite under partial exposure to sulfate attack, and their sulfate resistance increased as the nanosilica content increased (in the range of 0 to 5 wt% replacing cement by weight). The main sulfate products were gypsum and ettringite within the surface and inner parts, respectively in both the immersed and evaporation portions of the nanosilica-cement composites, which was consistent with the plain cement composite. Thus, the incorporation of nanosilica did not change the distribution characteristics of the sulfate products within the composites partially exposed to sulfate attack. However, the addition of nanosilica reduced the amount of sulfate products in both the immersed and evaporation portions, and their amount decreased with the increase of nanosilica content. The evaporation portions of the composites suffered chemical sulfate attack rather than sulfate salt crystallization. Nanosilica-cement composites could be applied in real partial exposure environments containing sulfate ions.

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