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ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis
Song, Eun Kyung,Jeon, Jimin,Jang, Dong Gil,Kim, Ha Eun,Sim, Hyo Jung,Kwon, Keun Yeong,Medina-Ruiz, Sofia,Jang, Hyun-Jun,Lee, Ah Reum,Rho, Jun Gi,Lee, Hyun-Shik,Kim, Seok Jung,Park, Chan Young,Myung, K American Association for the Advancement of Scienc 2018 Science translational medicine Vol.10 No.462
<P>Developing and mature chondrocytes constantly interact with and remodel the surrounding extracellular matrix (ECM). Recent research indicates that integrin-ECM interaction is differentially regulated during cartilage formation (chondrogenesis). Integrin signaling is also a key source of the catabolic reactions responsible for joint destruction in both rheumatoid arthritis and osteoarthritis. However, we do not understand how chondrocytes dynamically regulate integrin signaling in such an ECM-rich environment. Here, we found that developing chondrocytes express integrin-beta-like 1 (Itgbl1) at specific stages, inhibiting integrin signaling and promoting chondrogenesis. Unlike cytosolic integrin inhibitors, ITGBL1 is secreted and physically interacts with integrins to down-regulate activity. We observed that Itgbl1 expression was strongly reduced in the damaged articular cartilage of patients with osteoarthritis (OA). Ectopic expression of Itgbl1 protected joint cartilage against OA development in the destabilization of the medial meniscus-induced OA mouse model. Our results reveal ITGBL1 signaling as an underlying mechanism of protection against destructive cartilage disorders and suggest the potential therapeutic utility of targeting ITGBL1 to modulate integrin signaling in human disease.</P>
산업용 교반기의 고체-액체 혼합에 대한 Eulerian Two-Phase 유동해석
송애경(Aekyung Song),허남건(Nahmkeon Hur),원찬식(Chan-Shik Won),안익진(Ickjin Ahn) 한국유체기계학회 2006 유체기계 연구개발 발표회 논문집 Vol.- No.-
The Mixer is apparatus that help precipitation or an inhomogeneous distribution of various phases to be mixed and that user makes necessary material mixing one or the other. Mainly the mixer which is used from chemical and food industry is very important system in engineering that mixes the material. The inside flow of the mixer under the actual states which put a basis in flow of the fluid is formed rotation of the impeller. The inside flow of impeller will be caused by various reasons change with shape of impeller, number of rotation, mixing material and flow pattern of free surface etc. Also mixer study depended in single-phase flow and experimental research. So the numerical analysis of flow mixing solid-fluid particle is simulated. It is become known, that the case where agitator inside working fluid includes the solid particle the sinkage reverse which the solid particle has decreases an agitation efficiency. From the research which it sees the hazard solid which examines the effect where the change of the sinkage territory which it follows agitation number of revolution and diameter of the particle goes mad to an agitator inside flow distribution - numerical analysis the inside flow distribution of liquid state with Eulerian Two-Phase Method.