Urinary concentration of transforming growth factor-&bgr;-inducible gene-h3(&bgr;ig-h3) in patients with Type 2 diabetes mellitus

Cha, D. R.,Kim, I. S.,Kang, Y. S.,Han, S. Y.,Han, K. H.,Shin, C.,Ji, Y. H.,Kim, N. H. Blackwell Science Ltd 2005 Diabetic medicine Vol.22 No.1

<P>Abstract</P><P>Aims </P><P>The expression of TGF&bgr;-inducible gene h3(&bgr;ig-h3) has been used to assess the biological activity of TGF&bgr; in the kidney. In this study, we investigated whether the urinary concentration of &bgr;ig-h3 is associated with diabetic nephropathy in patients with Type 2 diabetes mellitus. We also evaluated the relationship between the urinary concentration of &bgr;ig-3 and proteinuria and microalbuminuria (AER) in a normal healthy population and in Type 2 diabetes patients.</P><P>Methods </P><P>Four hundred and seventy-nine Type 2 diabetic patients without non-diabetic kidney diseases and 528 healthy control subjects were enrolled. The study subjects were divided into five groups: a non-diabetic healthy control group with normal ACR (<I>n</I> = 443), a non-diabetic healthy control group with microalbuminuria (<I>n</I> = 85), a normoalbuminuric diabetic group (<I>n</I> = 198), a microalbuminuric diabetic group (<I>n</I> = 155) and an overt proteinuria group (<I>n</I> = 126). Urinary levels of &bgr;ig-h3 were measured by enzyme-linked immunosorbent assay.</P><P>Results </P><P>(i) Urinary excretion of &bgr;ig-h3 was significantly higher in the diabetic groups than in the controls, even in the normoalbuminuric stage (25.02 ± 8.84 vs. 18.67 ± 6.56, <I>P</I> = 0.03). In diabetic patients, urinary &bgr;ig-h3 levels increased significantly as diabetic nephropathy advanced (25.02 ± 8.84 vs. 34.06 ± 24.55 vs. 169.63 ± 57.33, <I>P</I> < 0.001). (ii) Proteinuria was found to be significantly correlated with urinary &bgr;ig-h3 (healthy control; <I>r</I> = 0.137, <I>P</I> = 0.019, diabetic patients; <I>r</I> = 0.604, <I>P</I> < 0.001). ACR was also found to be significantly related with urinary &bgr;ig-h3 in diabetic patients (<I>r =</I> 0.383, <I>P</I> = 0.006). (iii) In diabetic patients, urinary &bgr;ig-h3 was significantly related with systolic and diastolic blood pressure (systolic blood pressure: <I>r</I> = 0.436, <I>P</I> = 0.024; diastolic blood pressure, <I>r</I> = 0.365, <I>P</I> = 0.042), total cholesterol and HbA<SUB>1c</SUB> (cholesterol: <I>r</I> = 0.169, <I>P</I> = 0.03, HbA<SUB>1c</SUB>; <I>r</I> = 0.387, <I>P</I> = 0.044). Logistic regression analyses showed that urinary &bgr;ig-h3 was associated with a significant increase in the risk of microalbuminuria and proteinuria in diabetic patients.</P><P>Conclusions </P><P>Longitudinal monitoring of urinary &bgr;ig-h3 may improve the likelihood of detecting diabetic nephropathy at an earlier stage and &bgr;ig-h3 could be a sensitive marker of diabetic kidney disease progression.</P>

혈액검체로부터 분리된 황색포도구균의 독소유전자형 및 PFGE 분석

이영선,차정옥,정영희,최연화,양숙자,김홍빈,유재일,김봉수 국립보건연구원 2000 국립보건원보 Vol.37 No.-

임상검체에서 분리된 H. influenzae 의 생물형 분포

박정준 ( J J Park ),이현임 ( H I Lee ),이인숙 ( I S Lee ),차경호 ( K H Cha ) 대한임상검사과학회 1993 대한임상검사과학회지(KJCLS) Vol.25 No.1

Haemophilus influenza, one of the normal flora of upper respiratory tract, may csuse vari-ous infection. To assess the H. influenza biotype and β-Lactamase producer among clinical isolates of H. influenza, a total 97 isolater were tested. The following results were obtained. 1. Among total 97 isolates, H. influenze biotype were : biotype I 5(10%), II 20(40%), III 16(32%), V 1(4%), VII 6(12%), VIII 1(2%) out of 50 Throat biotype I 7(20%), II 12(34.3%), III 11(31.4%), V 3(8.6%), VI 1 (2.8%), VII 1(33.3%) out of 35 sputum. Biotype I 2(66.7%), III 1(33.3%) out of 3 blood culture biotype I 2(66.7%), III 1(33.3%) out of 3ear discharge biotype II 2(100%) out of 2 CSF biotype II 2 (100%) out of 2 sinus cavity biotype IV 1(100%) out of 1 Oral cavity biotype VI 1 (100%)out of 1 neck dis- charge 2. Among total 97 isolates, β-lactmase produ-ers were: 29(58%) out of 50 throat, 18(51%)out of 33 sputum,1(33%) out of 3 blood cultre, 1(33%) out of 3 ear discharge, 2(100%) out of 2 C.S.F, 1(100%) out of 1 oral cavity, 1(100%) out of 1 neck discharge

Mechanism for Shape Control of Cu Nanocrystals Prepared by Polyol Process

Cha Seung-I.,Kim Kyung-T.,Mo Chan-B.,Jeong Yong-J.,Hong Soon-H. 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1

This study investigated a mechanism for controlling the shape of Cu nanocrystals fabricated using the polyol process, which considers the thermodynamic transition from a facetted surface to a rough surface and the growth mechanisms of nanocrystals with facetted or rough surfaces. The facetted surfaces were stable at relatively low temperatures due to the low entropy of perfectly facetted surfaces. Nanocrystals fabricated using a coordinative surfactant stabilized the facetted surface at a higher temperature than those fabricated using a non-coordinative surfactant. The growth rate of the surface under a given driving force was dependent on the surface structure, i.e., facetted or rough, and the growth of a facetted surface was a thermally activated process. Surface twins decreased the activation energy for growth of the facetted surface and resulted in rod- or wire-shaped nanocrystals

음란물 접촉과 청소년의 성 가치관의 변화 : 서울 일개 중학교를 중심으로

김가영,김슬기,김지아,박다현,연현숙,오연경,주혜인,차근영 이화여자대학교 간호과학대학 2011 이화간호학회지 Vol.- No.45

This document's purposes are to give basic data in the viewpoint of nursing through investigation on the change of teenager's sexual values resulted from pornography experience. 150 middle school boy students who were in first, second and third grade were surveyed. Investigated place is limited only one school which is located in Seoul city. 123 Data was available among the 150 surveyed data. Collected data are statistically processed using SPSS program. To verify the reliability, Cronbach'a was applied and analysed using t- test, ANOVA. In short, the main results of this survey are as follows. 1. The general characteristics of surveyed students: Most of surveyed students were middle school 3rdgrade(42.5%) who had computer at their room ranked first (47.2%). The average using time of internet was more than 2 hours (35.4%, the highest rate). 76.6% of surveyed students answered that they had experience of watching the pornography. 2. 53.1% of surveyed students, which is the highest ratio, experienced pornography before they entered middle school. The curiosity rank first (57.%) about the question why they watch pornography. In case of students who had no experiences of pornography answered that they didn't watch pornography because they had no concern on pornography (51.6%). 3. On sexual values, the average scores of pornography non-experienced (3.77±0.46, full score: 5..0) are higher than those of pornography-experienced (3.53±0.51), showing statically significant difference against pornography -experienced group. 4. Findings of sexual values scores on general characteristics were as follows; The higher in grades, the lower in scores. Top-graded students gained higher scores of sexual values than low graded students showing statistically significant difference in both case of characteristics.

Photo-catalytic activity of hydrophilic-modified TiO₂ for the decomposition of methylene blue and phenol

Cha, B.J.,Woo, T.G.,Park, E.J.,Kim, I.H.,An, J.E.,Seo, H.O.,Kim, Y.D. Elsevier 2017 Current Applied Physics Vol.17 No.11

<P>We applied hydrophilic surface modification to P-25 TiO2 nanoparticles via thermal deposition of polydimethylsiloxane (PDMS), followed by annealing at 800 degrees C under vacuum conditions. This process yielded a thin layer consisting of hydrophilic organic functional groups (e.g., -C = O) as well as SiOx structures on the surface of TiO2. Compared to bare TiO2, the surface-modified TiO2 showed a higher adsorption capacity and photo-catalytic decomposition rate toward methylene blue. However, regarding the photo-catalytic decomposition of phenol, total mineralization of phenol was more complete when bare TiO2 was used as a photo-catalyst, whereas partial oxidation of phenol (i.e., into hydroquinone) was more dominant and total oxidation of phenol was supressed in the presence of surface-modified TiO2. Overall, one cannot simply say that hydrophilic modification of TiO2 leads to a higher affinity to H2O molecules with a higher yield of strongly-oxidizing agents (OH radicals) to increase the photo-catalytic activity in aqueous solutions. Our results imply that a subtle balance of the adsorption energy or rates of H2O, reactants, and reaction intermediates can be important factors for determining the photo-catalytic reaction rate. Different types of photo-catalyst surface modification can be beneficial or detrimental depending on the reaction. It is highlighted that one should be wary of evaluating the overall photocatalytic activities of dissimilar catalysts based on the results of only a couple of reactions. (C) 2017 Elsevier B.V. All rights reserved.</P>

체외 수정 및 배아의 자궁내 이식에 의한 임신 성공1예

이임순,박화숙,이순곤,차상헌,이권해,조태호 순천향대학교 1991 논문집 Vol.14 No.2

In vitro fertilization (IVF) and embryo transfer (ET) were initially geared to the treatment of woman with uncorrectable tubal infertility. However, IVF and ET has broadened its indication to encompass a wide variety of infertility disorders. In addition to surmounting intractable problems of infertility, program of IVF have contributed much to our knowledge of reproductive physiology. The embryos were obtained by in vitro fertilization of eight prevulatory eggs aspirated 36 hours after the injection of hCG during the patient's hyperstimulated menstrual cycle with follicle stimulating hormone (FSH) and human menopauasal gonadotropin (hMG). Level of serum β-hCG confirmed the presence of an early pregnancy. Ultrasund examination revealed intra-uterine gestational sac at 5 weeks. But this case resulted in abortion at 11 weeks unfortunately.

변곡점 및 단구간 에너지평가에 의한 음성의 천이구간 특징분석

최일홍,장승관,차태호,최웅세,김창석 한국음성과학회 1998 음성과학 Vol.3 No.-

In this paper, I would like to propose a dividing method by estimating the inflection points and the average magnitude energy in speech signals. The method proposed in this paper gave not only a satisfactory solution for the problems on dividing method by zero-crossing rate, but could estimate the feature of the transient period after dividing the starting point and transient period in speech signals before steady state. In the results of the experiment carried out with monosyllable speech, it ws found that even through speech samples indicated in D.C. level, the staring and ending point of the speech signals were exactly divided by the method. In addition to the results, I could compare with the features, such as the length of transient period, the short term energy, the frequency characteristics, in each speech signal. Keywords: inflection points, speech signal, transient period, short-term energy

KMT-2016-BLG-0212: First KMTNet-Only Discovery of a Substellar Companion

K.-H. Hwang,H.-W. Kim,D.-J. Kim,A. Gould,M. D. Albrow,S.-J. Chung,C. Han,Y. K. Jung,Y.-H. Ryu,I.-G. Shin,Y. Shvartzvald,J. C. Yee,W. Zang,W. Zhu,S.-M. Cha,S.-L. Kim,C.-U. Lee,D.-J. Lee,Y. Lee,B.-G. Pa 한국천문학회 2018 Journal of The Korean Astronomical Society Vol.51 No.6

We present the analysis of KMT-2016-BLG-0212, a low flux-variation $(I_{\rm flux-var}\sim 20$ mag) microlensing event, which is in a high-cadence ($\Gamma = 4 {\rm hr}^{-1}$) field of the three-telescope Korea Microlensing Telescope Network (KMTNet) survey. The event shows a short anomaly that is incompletely covered due to the brief visibility intervals that characterize the early microlensing season when the anomaly occurred. We show that the data are consistent with two classes of solutions, characterized respectively by low-mass brown-dwarf $(q=0.037)$ and sub-Neptune $(q<10^{-4})$ companions. Future high-resolution imaging should easily distinguish between these solutions.

계절 및 지역적 특성을 고력한 태양광발전 태양열시스템의 원격제어에 관한 연구

윤형상(H.S. Yoon),강병복(B.B. Kang),임중열(J.Y. Lim),윤필현(P.H. YooN),차인수(I.S. Cha) 전력전자학회 2003 전력전자학술대회 논문집 Vol.2003 No.7(2)

본 시스템은 나주 생물자원산업화센터에 설치된 태양광 및 태양열 시스템에 대한 운전결과특성으로 써 특용작물배양의 전원 및 온수공급을 위한 것이다 . 태양광발전은 lOkWP이고, 태양열시스템은 500 I로 구성되어 있다 태양광발전시스템의 인버터는 10kW급 계통연계형으로써 상용전원과 연계해서 사용할 수 있도록 하였으며 태양열시스템은 생물자원산업화센터의 실험용 급탕으로 사용된다. 본 논문에서는 태양광발전과 태양열시스템이 설치된 생 물자원산업화센터에 상주 근무인원을 대체하기 위해서 원격 모니터링 시스템을 구성하였고, 모니터링에 의해 축적된 데이터를 통해 그 특성을 비교하고자 한다.<br/>