http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : C. D. Upasani (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Jadhav, G.B.,Upasani, C.D. 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.2
The objective of the present investigation was to evaluate the therapeutic efficacy of Silymarin in DOCA salt induced hypertension in unilateral nephrectomized rats. Unilateral nephrectomy was performed in female Wistar rats (150-200 g). A week after unilateral nephrectomy, hypertension was induced by DOCA (25 mg/kg, once a week; s.c; for 4 weeks) dispersed in cottonseed oil. The effect of Silymarin (300 mg/kg and 500 mg/kg, p. o., for 4 weeks) was evaluated in DOCA salt induced hypertensive rats. Systolic blood pressure (BP) was measured once every week during the treatment schedule. After completion of treatment schedule, heart rate, arterial blood pressure and vascular reactivity to various drugs were recorded. Rats from individual group were sacrificed, the heart was dissected out and antioxidant enzyme level SOD, CAT, GSH and TBARS were measured. Urine excretions were measured by flame photometer. Silymarin (300, 500 mg/kg/day, p.o.) significantly ($p$ <0.05) reduced systolic blood pressure, heart rate, basal arterial blood pressure and pressor responses to NA, Adr, PE and 5-HT in animals treated with DOCA salt as compared with DOCA-salt hypertensive rats. Silymarin significantly increased antioxidant enzyme level of SOD, CAT, GSH, urinary $Na^+$ excretion and decreased TBARS level, urinary $K^+$ excretion compared with DOCA hypertensive group. Silymarin exhibits significant antihypertensive activity in DOCA salt model of hypertension.
-
G. B. Jadhav,C. D. Upasani 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.2
The objective of the present investigation was to evaluate the therapeutic efficacy of Silymarin in DOCA salt induced hypertension in unilateral nephrectomized rats. Unilateral nephrectomy was performed in female Wistar rats (150–200 g). A week after unilateral nephrectomy,hypertension was induced by DOCA (25 mg/kg, once a week; s.c; for 4 weeks) dispersed in cottonseed oil. The effect of Silymarin (300 mg/kg and 500 mg/kg, p. o., for 4 weeks) was evaluated in DOCA salt induced hypertensive rats. Systolic blood pressure (BP) was measured once every week during the treatment schedule. After completion of treatment schedule, heart rate, arterial blood pressure and vascular reactivity to various drugs were recorded. Rats from individual group were sacrificed, the heart was dissected out and antioxidant enzyme level SOD, CAT, GSH and TBARS were measured. Urine excretions were measured by flame photometer. Silymarin (300, 500 mg/kg/day, p.o.)significantly (p<0.05) reduced systolic blood pressure,heart rate, basal arterial blood pressure and pressor responses to NA, Adr, PE and 5-HT in animals treated with DOCA salt as compared with DOCA-salt hypertensive rats. Silymarin significantly increased antioxidant enzyme level of SOD, CAT, GSH, urinary Na^+ excretion and decreased TBARS level, urinary K^+ excretion compared with DOCA hypertensive group. Silymarin exhibits significant antihypertensive activity in DOCA salt model of hypertension.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
