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- 저자 : Bingxiang Wang (검색결과 2 건)
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Hailin He,Kanghua Chen,Youping Yi,Wen You,Yonglin Guo,Bingxiang Wang,Jiaguo Tang,Research Institute of Light Alloy, Central South University,Shiquan Huang 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.2
Optimization of forging process to improve the microstructure and mechanical properties of 2195 Al–Cu–Li alloy forgingsis an urgent issue. In this study, a homogenized 2195 alloy ingot was subjected to multi-directional forging (MDF), annealing,and forging at 500 °C, 420 °C, and 240 °C with a 50% reduction in cross-sectional area, followed by a T8 heat treatment(involving solution, quenching, cold compression, and aging). The microstructural evolution during the process and thefinal mechanical properties in three orthogonal directions were examined. The results showed that the grain structures ofthe alloy were significantly refined after MDF by dynamic recrystallization (DRX), but the structure was thermally unstableand formed coarse grains during subsequent annealing by static recrystallization (SRX). The T8-treated samples forged at500 °C, 420 °C, and 240 °C obtained fine and uniform grain structures by DRX, inhomogeneous grain structures by partialSRX, and uniform, equiaxed grain structures by full SRX, respectively. The average grain size of the forging increased withdecreasing forging temperature because more significant SRX occurred for the forging that was deformed at lower temperatures. The grain structures had minimal influence on precipitation behavior and strength but had a significant influence onelongation. The fine and uniform grain structures improved the elongation; whereas, the inhomogeneous grain structures,which contained extremely large grains, significantly deteriorated the elongation. The uniform, equiaxed grain structuresdecreased the anisotropy in three orthogonal directions and maintained fine elongation even though the average grain sizeof the forging was the largest.
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The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy
Zhao Weichen,He Chunyuan,Jiang Junjie,Zhao Zongbiao,Yuan Hongzhong,Wang Facai,Shen Bingxiang 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.6
Pyroptosis, a form of cell death associated with inflammation, is known to be involved in diabetic nephropathy (DN), and discoid domain receptor 1 (DDR1), an inflammatory regulatory protein, is reported to be associated with diabetes. However, the mechanism underlying DDR1 regulation and pyroptosis in DN remains unknown. We aimed to investigate the effect of DDR1 on renal tubular epithelial cell pyroptosis and the mechanism underlying DN. In this study, we used high glucose (HG)-treated HK-2 cells and rats with a single intraperitoneal injection of streptozotocin as DN models. Subsequently, the expression of pyroptosis-related proteins (cleaved caspase-1, GSDMD-N, Interleukin-1β [IL-1β], and interleukin-18 [IL-18]), DDR1, phosphorylated NF-κB (p-NF-κB), and NLR family pyrin domain-containing 3 (NLRP3) inflammasomes were determined through Western blotting. IL-1β and IL-18 levels were determined using ELISA. The rate of pyroptosis was assessed by propidium iodide (PI) staining. The results revealed upregulated expression of pyroptosisrelated proteins and increased concentration of IL-1β and IL-18, accompanied by DDR1, p-NF-κB, and NLRP3 upregulation in DN rat kidney tissues and HG-treated HK-2 cells. Moreover, DDR1 knockdown in the background of HG treatment resulted in inhibited expression of pyroptosis-related proteins and attenuation of IL-1β and IL-18 production and PI-positive cell frequency via the NF-κB/NLRP3 pathway in HK-2 cells. However, NLRP3 overexpression reversed the effect of DDR1 knockdown on pyroptosis. In conclusion, we demonstrated that DDR1 may be associated with pyroptosis, and DDR1 knockdown inhibited HG-induced renal tubular epithelial cell pyroptosis. The NF-κB/NLRP3 pathway is probably involved in the underlying mechanism of these findings.
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