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Recent Advances in Scanning Acoustic Microscopy for Adhesion Evaluation of Thin Films
Ju, Hyeong-Sick,Tittmann, Bernhard R. The Korean Society for Nondestructive Testing 2009 한국비파괴검사학회지 Vol.29 No.6
As the thin film technology has emerged in various fields, adhesion of the film interface becomes an important issue in terms of the longevity and durability of thin film devices. Diverse nondestructive methods utilizing acoustic techniques have been developed to assess the interfacial integrity. As an effective technique based on the ultrasonic wave focusing and the surface acoustic wave(SAW) generation, scanning acoustic microscopy(SAM) has been investigated for adhesion evaluation. Visualization of film microstructures and quantification of adhesion weakness levels by SAW dispersion are the recent achievements of SAM. To overcome the limitations in the theoretical dispersion model only suitable for perfectly elastic and isotropic materials, a new model has been more recently developed in consideration of film anisotropy and viscoelasticity and applied to the adhesion evaluation of polymeric films fabricated on semiconductive wafers.
Recent Advances in Scanning Acoustic Microscopy for Adhesion Evaluation of Thin Films
Hyeong Sick Ju,Bernhard R. Tittmann 한국비파괴검사학회 2009 한국비파괴검사학회지 Vol.29 No.6
As the thin film technology has emerged in various fields, adhesion of the film interface becomes an important issue in terms of the longevity and durability of thin film devices. Diverse nondestructive methods utilizing acoustic techniques have been developed to assess the interfacial integrity. As an effective technique based on the ultrasonic wave focusing and the surface acoustic wave(SAW) generation, scanning acoustic microscopy(SAM) has been investigated for adhesion evaluation. Visualization of film microstructures and quantification of adhesion weakness levels by SAW dispersion are the recent achievements of SAM. To overcome the limitations in the theoretical dispersion model only suitable for perfectly elastic and isotropic materials, a new model has been more recently developed in consideration of film anisotropy and viscoelasticity and applied to the adhesion evaluation of polymeric films fabricated on semiconductive wafers.
Recent Ultrasonic Guided Wave Inspection Development Efforts
Rose, Joseph L.,Tittmann, Bernhard R. 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.4
The recognition of such natural wave guides as plates, rods, hollow cylinder, multi-layer structures or simply an interface between two material combined with an increased understanding of the physics and wave mechanics of guided wave propagation has led to a significant increase in the number of guided wave inspection applications being developed each year. Of primary attention is the ability to inspect partially hidden structure, hard to access areas, and coated or insulated structures, An inteoduction to some physical consideration of guided waves followed by some sample problem description in pipe, ice detection, fouling detection in the foods industry, aircraft, tar coated structures and acoustic microcopy is presented in this paper. A sample problem in Boundary Element Modeling is also presented to illustrate the move in guided wave analysis beyond detection and location analysis to quantification.
A Systems Approach to Predict Oncometabolites via Context-Specific Genome-Scale Metabolic Networks
Nam, Hojung,Campodonico, Miguel,Bordbar, Aarash,Hyduke, Daniel R.,Kim, Sangwoo,Zielinski, Daniel C.,Palsson, Bernhard O. Public Library of Science 2014 PLoS computational biology Vol.10 No.9
<▼1><P>Altered metabolism in cancer cells has been viewed as a passive response required for a malignant transformation. However, this view has changed through the recently described metabolic oncogenic factors: mutated isocitrate dehydrogenases (IDH), succinate dehydrogenase (SDH), and fumarate hydratase (FH) that produce oncometabolites that competitively inhibit epigenetic regulation. In this study, we demonstrate <I>in silico</I> predictions of oncometabolites that have the potential to dysregulate epigenetic controls in nine types of cancer by incorporating massive scale genetic mutation information (collected from more than 1,700 cancer genomes), expression profiling data, and deploying Recon 2 to reconstruct context-specific genome-scale metabolic models. Our analysis predicted 15 compounds and 24 substructures of potential oncometabolites that could result from the loss-of-function and gain-of-function mutations of metabolic enzymes, respectively. These results suggest a substantial potential for discovering unidentified oncometabolites in various forms of cancers.</P></▼1><▼2><P><B>Author Summary</B></P><P>Cancer and metabolism have been considered to be associated for a long period since Otto Warburg observed that tumor cells consume glucose and convert most of it to lactate, despite the presence of oxygen. However, the role of the Warburg effect in oncogenesis had been under doubt because no solid links between genetic variations in metabolic genes and cancer had been observed until recent days. When with the development of sequencing technologies, researchers found mutations in IDH1, IDH2 (isocitrate dehydrogenase) in medium-grade glioma and acute leukemia. As these mutated metabolic genes initiate unexpected enzymatic reactions, cancer cells show altered concentration of particular metabolites, here called “oncometabolites”. The oncometabolites regulate the epigenetic controls of cell differentiations. In this study, we predict potential oncometabolites that might originate from loss or gain-of-function mutations in nine types of cancer from massive scale cancer mutation data with a systems biology approach.</P></▼2>
Report from IPITA-TTS Opinion Leaders Meeting on the Future of &bgr;-Cell Replacement
Bartlett, Stephen T.,Markmann, James F.,Johnson, Paul,Korsgren, Olle,Hering, Bernhard J.,Scharp, David,Kay, Thomas W. H.,Bromberg, Jonathan,Odorico, Jon S.,Weir, Gordon C.,Bridges, Nancy,Kandaswamy, R Wolters Kluwer Health, Inc. All rights reserved. 2016 Transplantation Vol.100 No.2
Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of &bgr;-Cell Replacement
Markmann, James F.,Bartlett, Stephen T.,Johnson, Paul,Korsgren, Olle,Hering, Bernhard J.,Scharp, David,Kay, Thomas W. H.,Bromberg, Jonathan,Odorico, Jon S.,Weir, Gordon C.,Bridges, Nancy,Kandaswamy, R Williams & Wilkins Co 2016 Transplantation Vol.100 No.7
SUMMARY: The International Pancreas and Islet Transplant Association (IPITA), in conjunction with the Transplantation Society (TTS), convened a workshop to consider the future of pancreas and islet transplantation in the context of potential competing technologies that are under development, including the artificial pancreas, transplantation tolerance, xenotransplantation, encapsulation, stem cell derived beta cells, beta cell proliferation, and endogenous regeneration. Separate workgroups for each topic and then the collective group reviewed the state of the art, hurdles to application, and proposed research agenda for each therapy that would allow widespread application. Herein we present the executive summary of this workshop that focuses on obstacles to application and the research agenda to overcome them; the full length article with detailed background for each topic is published as an online supplement to Transplantation.