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RISS 인기검색어
- 검색키워드
- 저자 : Benjamin O. Emikpe (검색결과 2 건)
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Larbie Christopher,Nyarko Ruby A.,Oyagbemi Ademola A.,Jarikre Theophilus A.,Adjei Clement O.,Aseidu Emmanuel B.,Mawuenyega Rosemond,Emikpe Benjamin O. 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.4
Interest in medicinal plant research and usage has risen due to many reported side effects of synthetic drugs and their relatively higher cost. Ocimum americanum (family Lamiaceae) is a commonly used spice in Ghana with the aqueous extracts of leaves, flowers and stem been rich in saponins, alkaloids, flavonoids, and tannins. The aim of the study was to evaluate the nephroprotective potential of the aqueous extracts of O. americanum parts on gentamicin- and cisplatin-induced toxicity in rats. In a ten-day experiment, nephrotoxicity was induced with gentamicin (GM; 100 mg/kg b.wt. for 8 days) and cisplatin (Cisp; 6 mg/kg b.wt. for 1 day) after pre-treatment with 250 mg/kg b.wt. of the leaves, stem, and flower extracts of O. americanum and standard drug, silymarin (100 mg/kg b.wt.) for 10 days. The nephroprotective activity was evaluated by assaying the activity of serum kidney function parameter, kidney oxidative stress parameters, kidney inflammatory cytokines (NF-κB and IL-1) and histopathology. The activities of kidney function parameters of animals were significantly increased following Cisp and GM treatment with resultant alteration is kidney microarchitecture, over-expressions of NF-κB and IL1 and kidney oxidative stress markers. Extract pre-treatment restored kidney function to near-normal, downregulating the expressions of IL-1 and NF-κB and improved levels of reduced GSH contents, GPx and SOD activities. However, leaves extract showed the best protection against GM while all extracts showed improved protection (> 50%) against Cisp. Extract of Ocimum americanum exhibit nephroprotective activity and could be developed as a potent kidney protector.
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Noah Segun Oyetayo,Dorcas Oyueley Kodie,Martins I. Nwakasi,Oladapo O. Afolabi,Theophilus A. Jarikre,Oghenemega David Eyarefe,Benjamin O. Emikpe 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.4
Gastric ulcer is a serious global health challenge, and various natural products are being investigated to prevent and manage the condition. This study evaluated the gastroprotective and ulcer healing potentials of Nigerian bee propolis flavonoid-rich extract (NPE) on acetic acid-induced gastric ulcers in albino rats. Sixty adult male albino rats (222 ± 6.4 g) randomised into 5 groups (n = 12) were studied. Group A (SHAM) was left untreated, while gastric ulcer was induced in groups B (NPE), C (omeprazole) and D (saline). Group E (PRPE) was pre-treated with NPE prior to ulcer induction. The rate of ulcer contraction, volume and pH of gastric juice, and histopathological parameters were evaluated. The results showed a significantly higher rate of contraction (P = 0.001) between days 9 and 12 (NPE > OME > PRPE > SAL) and a significant decrease (P = 0.003) in the volume of gastric juice between days 9 and 12 (NPE < OME < PRPE). Gradual increase in pH was observed in all the groups from days 3 to 12, with a significantly higher rate (P < 0.001) between day 6 and 12 (SHAM > NPE > OME > PRPE > SAL). Histological evaluation showed significantly high neutrophils and macrophages on day 6 (P = 0.006) and lymphocytes (P = 0.004) between day 6 and 12 in the OME and NPE groups. NPE showed gastroprotective and ulcer healing properties by inhibiting ulcer formation and facilitating the curation of induced ulcers and is, therefore, a valuable alternative to conventional gastric ulcer therapy, especially in poor resource settings.
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