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- 저자 : Baydas Tuba (검색결과 1 건)
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The prognostic value of tumor budding in gastric adenocarcinomas: A cross-sectional study
Baydas Tuba,Coban Ganime,Besiroglu Mehmet,Simsek Melih,Shbair Abdallah TM,Topcu Atakan,Yasin Ayse Irem,Seker Mesut,Turk Haci Mehmet 소화기인터벤션의학회 2023 International journal of gastrointestinal interven Vol.12 No.2
Background: Tumor budding is a negative prognostic factor for many solid malignancies. We investigated the relationship between patients’ clinico-pathological characteristics and tumor budding, as well as the effect of budding level on prognosis. Methods: In this retrospective, cross-sectional, and descriptive study at a tertiary university hospital, 104 patients with gastric adenocarcinoma were divided into two groups according to whether they had a high (≥ 10 buds) or low (< 10 buds) level of budding. The patients were retrospectively evaluated.Results: Sixty-two patients had a low level of budding and 42 had a high level of budding. The mean time from the first diagnosis to the last follow-up was significantly longer (P < 0.05) in the low-budding group (27 months) than in the high-budding group (17 months). As the T stage, N stage, grade, and size of the tumor increased, the proportion of patients with high budding was found to be significantly higher (P < 0.05). High tumor budding, an age of 60 or over at diagnosis, a low body mass index, high N stage, presence of lymphovascular invasion, and recurrence were associ-ated with overall survival.Conclusion: Our study supports that budding is a negative prognostic factor in gastric cancer.
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