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- 저자 : Basnet Hom Bahadur (검색결과 3 건)
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Solute Carrier SLC41A1 "A MINI REVIEW"
Hom Bahadur Basnet 한국환경성돌연변이발암원학회 2005 한국환경성돌연변이·발암원학회지 Vol.25 No.2
The human solute carrier, SLC41A1, is a Mg²+ transporter that is regulated by extracellular magnesium. Although intracellular magnesium plays a fundamental role in cellular metabolism, little is known about how Mg²+ is taken up and controlled by cells. Magnesium plays a fundamental role in cellular metabolism so that its control within the body is critical. Magnesium homeostasis is principally a balance between intestinal absorption of dietary magnesium and renal excretion of urinary magnesium. The kidney, mainly the distal convoluted tubule, controls magnesium reabsorption. Although renal reabsorption is under the influence of many hormones, selective regulation of magnesium transport is due to intrinsic control involving transcriptional processes and synthesis of transport proteins. Using microarray analysis, identification of the genetic elements involved with this transcriptional control has been begun. SLC41A1 (GenBank Accession No. AJ514402), comprises 10 putative transmembrane domains, two of which are highly homologous to the integral membrane part of the prokaryote transports Mg²+ and other divalent cations Sr²+, Zn²+, Cu²+, Fe²+, Co²+, Ba²+, and Cd²+ but not Ca2+, Mn²+, and Ni2+. Transport of Mg²+ by SLC41A1 is rheogenic, voltage dependent, and not coupled to Na or Cl . Expressed SLC41A1 transports a range of other divalent cations: Mg²+, Sr²+, Zn²+, Cu²+, Fe²+, Co²+, Ba²+, and Cd²+. The divalent cations Ca²+, Mn²+, and Ni²+ and the trivalent ion Gd³+ did not induce currents nor did they inhibit Mg²+ transport. The nonselective cation La3+ abolishes Mg²+ uptake. Computer analysis of the SLC41A1 protein structure reveals that it belongs to MgtE protein family & suggested that the human solute carrier, SLC41A1, might be a eukaryotic Mg²+ transporter closely related (60-70%) protein encoded by SLC41A2 is a Mg²+ transporter that might be involved in magnesium homeostasis in epithelial cells also transports a range of other divalent cations: Ba², Ni², Co², Fe², or Mn², but not Ca², Zn², or Cu²+ that may have related functional properties.
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Solute Carrier SLC41A1 'A MINI REVIEW'
Basnet Hom Bahadur Korean Environmental Mutagen Society 2005 한국환경성돌연변이·발암원학회지 Vol.25 No.2
The human solute carrier, SLC41Al, is a $Mg^{2}+$ transporter that is regulated by extracellular magnesium. Although intracellular magnesium plays a fundamental role in cellular metabolism, little is known about how $Mg^{2}+$ is taken up and controlled by cells. Magnesium plays a fundamental role in cellular metabolism so that its control within the body is critical. Magnesium homeostasis is principally a balance between intestinal absorption of dietary magnesium and renal excretion of urinary magnesium. The kidney, mainly the distal convoluted tubule, controls magnesium reabsorption. Although renal reabsorption is under the influence of many hormones, selective regulation of magnesium transport is due to intrinsic control involving transcriptional processes and synthesis of transport proteins. Using microarray analysis, identification of the genetic elements involved with this transcriptional control has been begun. SLC41A1(GenBank Accession No. AJ514402), comprises 10 putative transmembrane domains, two of which are highly homologous to the integral membrane part of the prokaryote transports $Mg^{2}+$ and other divalent cations $Sr^2+,\;Zn^2+,\;Cu^2+,\;Fe^2+,\;Co^2+,\;Ba^2+,\;and\;Cd^2+,\;but\;not\;Ca^2+,\;Mn^2+,\;and\;Ni^2+.$ Transport of $Mg^{2}+$ by SLC41Al is rheogenic, voltage dependent, and not coupled to Na or Cl. Expressed SLC41Al transports a range of other divalent cations: $Mg^{2+},\;Sr^{2+},\;Zn^{2+},\;Cu^{2+},\;Fe^{2+},\;Co^{2+},\;Ba^{2+},\;and\;Cd^{2+}$. The divalent cations $Ca^{2+},\;Mn^{2+},\;and\;Ni^{2+}$and the trivalent ion $Gd^{3+}$ did not induce currents nor did they inhibit $Mg^{2+}$ transport. The nonselective cation $La^{3+}$ abolishes $Mg^{2+}$ uptake. Computer analysis of the SLC41Al protein structure reveals that it belongs to MgtE protein family & suggested that the human solute carrier, SLC41Al, might be a eukaryotic $Mg^{2+}$ transporter closely related $(60-70\%)$ protein encoded by SLC41A2 is a $Mg^{2}+$ transporter that might be involved in magnesium homeostasis in epithelial cells also transports a range of other divalent cations: $Ba^2,\;Ni^2,\;CO^2,\;Fe^2,\;or\;Mn^2,\;but\;not\;Ca^2,\;Zn^2,\;or\;Cu^{2+}$ that may have related functional properties.
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육계의 Erysipelothrix rhusiopathiae 감염 증례
바스넷홈바하둘 ( Hom Bahadur Basnet ),강민수 ( Min Su Kang ),김애란 ( Ae Ran Kim ),권혁준 ( Hyuk Joon Kwon ),김선중 ( Sun Joong Kim ),정병열 ( Byeong Yeal Jung ) 한국예방수의학회(구 한국수의공중보건학회) 2011 예방수의학회지 Vol.35 No.2
Erysipelothrix rhusiopathiae is a causative agent of erysipelas in avian and mammalian species globally. Eight dead 5-week-old Ross broiler chickens were submitted for diagnostic tests in September 2005. Typical signs including white necrotic foci on the liver, focal congestion of the pancreas, severe atrophy and hardening of the bursa of Fabricius were detected. E. rhusiopathiae was isolated from haemorrhagic lung samples. However, no specific PCR product for the viral diseases tested was detected in these chicken samples. To our best knowledge, this is the first report of the isolation of E. rhusiopathiae in broiler chickens in Korea.
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