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RISS 인기검색어
- 검색키워드
- 저자 : Baffert, Carole (검색결과 2 건)
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Long-Term and Sustained COMP-Ang1 Induces Long-Lasting Vascular Enlargement and Enhanced Blood Flow
Cho, Chung-Hyun,Kim, Kyung Eun,Byun, Jonghoe,Jang, Hyung-Suk,Kim, Duk-Kyung,Baluk, Peter,Baffert, Fabienne,Lee, Gyun Min,Mochizuki, Naoki,Kim, Jin,Jeon, Byeong Hwa,McDonald, Donald M.,Koh, Gou Young Ovid Technologies Wolters Kluwer -American Heart A 2005 Circulation research Vol.97 No.1
<P>Vascular enlargement is a characteristic feature of angiopoietin-1 (Ang1)-induced changes in adult blood vessels. However, it is unknown whether tissues having Ang1-mediated vascular enlargement have more blood flow or whether the enlargement is reversible. We have recently created a soluble, stable and potent Ang1 variant, COMP-Ang1. In the present study, we investigated the effects of varied dose and duration of COMP-Ang1 on vascular enlargement and blood flow in the tracheal microvasculature of adult mice and explored a possible mechanism of long-lasting vascular enlargement. We found that COMP-Ang1 administered by adenoviral vector induced long-lasting vascular enlargement and increased tracheal blood flow. In contrast, short-term administration of COMP-Ang1 recombinant protein induced transient vascular enlargement that spontaneously reversed within a month. In both cases, the vascular enlargement resulted from endothelial proliferation. The COMP-Ang1-induced vascular remodeling is mediated mainly through Tie2 activation. Sustained overexpression of Tie2 could participate in the maintenance of vascular changes. Together, our findings indicate that sustained treatment with COMP-Ang1 can produce long-lasting vascular enlargement and increased blood flow.</P>
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Borondifluoride complexes of hemicurcuminoids as bio-inspired push–pull dyes for bioimaging
Kim, Eunsun,Felouat, Abdellah,Zaborova, Elena,Ribierre, Jean-Charles,Wu, Jeong Weon,Senatore, Sé,bastien,Matthews, Cé,dric,Lenne, Pierre-Franç,ois,Baffert, Carole,Karapetyan, Artak,G The Royal Society of Chemistry 2016 Organic & Biomolecular Chemistry Vol.14 No.4
<P>Hemicurcuminoids are based on half of the pi-conjugated backbone of curcuminoids. The synthesis of a series of such systems and their borondifluoride complexes is described. The electrochemical and photophysical properties of difluorodioxaborine species were investigated as a function of the nature of electron donor and acceptor groups appended at either terminal positions of the molecular backbone. The emissive character of these dipolar dyes was attributed to an intraligand charge transfer process, leading to fluorescence emission that is strongly dependent on solvent polarity. Quasi-quantitative quenching of fluorescence in high polarity solvents was attributed to photoinduced electron transfer. These dyes were shown to behave as versatile fluorophores. Indeed, they display efficient two-photon excited fluorescence emission leading to high two-photon brightness values. Furthermore, they form nanoparticles in water whose fluorescence emission quantum yield is less than that of the dye in solution, owing to aggregation-induced fluorescence quenching. When cos7 living cells were exposed to these weakly-emitting nanoparticles, one-and two-photon excited fluorescence spectra showed a strong emission within the cytoplasm that originated from the individual molecules. Dye uptake thus involved a disaggregation mechanism at the cell membrane which restored fluorescence emission. This off-on fluorescence switching allows a selective optical monitoring of those molecules that do enter the cell, which offers improved sensitivity and selectivity of detection for bioimaging purposes.</P>
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