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Bac Tran Le,Jung-Eun Park 한국예방수의학회 2023 예방수의학회지 Vol.47 No.4
Previous studies have shown that proline mutations in the heptad repeat region stabilize the coronavirus spike (S) protein in a pre-fusion state. To understand the impact of proline substitutions on the fusogenicity of the S protein, we engineered the swine acute diarrhea syndrome coronavirus (SADS-CoV) S protein with two proline substitutions (S-PP) and examined its fusogenicity using dual-split-protein based cell-cell fusion assay. Unlike the wild-type S (S-WT), S-PP rarely formed syncytia. Additionally, protein expression of S-PP was impaired compared to S-WT, as previously reported. Our results indicate that pre-fusion stabilized S protein is unable to induce membrane fusion and provide a better understanding of SADS-CoV S and vaccine antigen design.
( Le Huy Bac ) 부산외국어대학교 아세안연구원 2012 Suvannabhumi Vol.4 No.2
This study explores the concept of postmodernism in literature. There are many ideas which have conflicted with each other, but now postmodernism is real concept. We cannot deny. By researching papers of Jean-Francois Lyotard, Jean Baudrillard, Jacques Derrida, Michel Foucault, Julia Kristeva, Roland Barthes, Ihab Hassan etc. we find out many characteristics of postmodernism. From that, we propose a conceptual understanding of postmodern literature as follows: Starting from the late 1910s with the poetry of Dadaism (1916), Franz Kafka`s prose (Metamorphosis 1915) and drama by Samuel Beckett (Waiting for Godot 1953), postmodern literature coexists with modern literature and is a thriving form from 1960 on. Postmodernism is opposed to modernism in nature in that it accepts nothingness, chaos, games and intertextuality. It tries to solve some difficult problems of modernism making use of science to free people from a life of darkness and dogma. Postmodernism is associated with the information technology revolution, an economic, scientific and technological boom and rapid urbanization.
Le Huy Bac, A 부산외국어대학교 아세안연구원 2012 Suvannabhumi Vol.4 No.2
This study explores the concept of postmodernism in literature. There are many ideas which have conflicted with each other, but now postmodernism is real concept. We cannot deny. By researching papers of Jean‐François Lyotard, Jean Baudrillard, Jacques Derrida, Michel Foucault, Julia Kristeva, Roland Barthes, Ihab Hassan etc. we find out many characteristics of postmodernism. From that, we propose a conceptual understanding of postmodern literature as follows: Starting from the late 1910s with the poetry of Dadaism (1916), Franz Kafka’s prose (Metamorphosis 1915) and drama by Samuel Beckett (Waiting for Godot 1953), postmodern literature coexists with modern literature and is a thriving form from 1960 on. Postmodernism is opposed to modernism in nature in that it accepts nothingness, chaos, games and intertextuality. It tries to solve some difficult problems of modernism making use of science to free people from a life of darkness and dogma. Postmodernism is associated with the information technology revolution, an economic, scientific and technological boom and rapid urbanization.
Postmodern Vietnamese Literature
Le Huy Bac 부산외국어대학교 동남아지역원 2014 Suvannabhumi Vol.6 No.1
This study explores postmodernism in Vietnamese literature. While there has been much dispute among critics regarding postmodernism in Vietnamese literature, postmodernism is now thought to be something that cannot be denied. Vietnamese postmodernism has Vietnamese characteristics and is strongly influenced by American literature. The structure of some Vietnamese short stories is similar to that of some American writers. In the writings of Jean-François Lyotard, Jean Baudrillard and Ihab Hassan, for example, we find out many characteristics which are ascribed to postmodern Vietnamese literature. We propose the use of the term ‘Lao Tzu discourse’which is to include the main concepts of postmodernism such as chaos, nothingness and fragmentation. We propose that postmodern Vietnamese Literature appeared in the 1940s with the collection, Fall Spring Poems (1942), and is also seen with the prose of Nguyen Khai and Nguyen Minh Chau in the 1980s, and the drama written by Luu Quang Vu in the 1980s. There now exists a large group of postmodern Vietnamese writers, like Le Dat, Thanh Thao, Bao Ninh, Cao Duy Son, Nguyen Ngoc Tu and Nguyen Binh Phuong, among others. Keywords: Vietnam; Vietnamese postmodernism; Postmodernism; Lao Tzu discourse; Keyboard writing.
Multiple Genotypes of Avian Infectious Bronchitis Virus Circulating in Vietnam
Tran Bac Le,Hyun-Jeong Lee,Van Phan Le,최강석 한국가금학회 2019 韓國家禽學會誌 Vol.46 No.2
Three strains of infectious bronchitis viruses (IBVs), designated VNUA3, VNUA8 and VNUA11, were isolated from diseased/infected chickens in Hanoi, Thainguyen, and Haiphong provinces of Vietnam. These birds had received a live IBV vaccination but still suffered from infectious bronchitis. VNUA3, VNUA8 and VNUA11 harbor cleavage sites (RRTGR, HRRRR, and HRRKR, respectively) within the S protein. A BLASTN search revealed that the S gene of VNUA3, VNUA8, and VNUA11 showed the highest nucleotide identity with those of IBV strains CK/Italy/I2022/13, CK/CH/LHLJ/08-6, and GX-NN120084, respectively. Phylogenetic analyses based on the S gene nucleotide sequences revealed that VNUA3, VNUA8 and VNUA11 clustered with Q1-like, QX-like and TC07-2-like genotypes, respectively, and were closely related to reference IBV strains from China. However, the Vietnam IBVs showed high divergence from vaccine strains 4/91 and Ma5, which are used in the Vietnamese farms from which the isolates were obtained. Taken together, these results indicate that at least three genotypes of IBV are circulating among chickens in North Vietnam. This is the first report of the molecular epidemiology of IBV in Vietnam.
Huong, Truong Thu,Bac, Ta Phuong,Thang, Bui Doan,Long, Dao Minh,Quang, Le Anh,Dan, Nguyen Minh,Hoang, Nguyen Viet International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.6
Since machine learning was invented, there have been many different machine learning-based algorithms, from shallow learning to deep learning models, that provide solutions to the classification tasks. But then it poses a problem in choosing a suitable classification algorithm that can improve the classification/detection efficiency for a certain network context. With that comes whether an algorithm provides good performance, why it works in some problems and not in others. In this paper, we present a data-centric analysis to provide a way for selecting a suitable classification algorithm. This data-centric approach is a new viewpoint in exploring relationships between classification performance and facts and figures of data sets.