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        Effect of prior cesarean delivery on the outcomes of intracytoplasmic sperm injection

        Suzan Atteya Gewida,Mohamed Salah Eldeen Abd Rabbo,Mohammed Abd Elmoety El Samra,Hesham Mahmoud Adel Abdel Moneim The Korean Society for Reproductive Medicine 2024 Clinical and Experimental Reproductive Medicine Vol.51 No.1

        Objective: This study was conducted to investigate the impact of previous delivery mode on pregnancy outcomes in patients with secondary infertility after frozen-thawed embryo transfer. Methods: This prospective observational study included 140 patients experiencing secondary infertility. Of these, 70 patients had a previous cesarean delivery (CD), while the remaining 70 patients had a previous normal vaginal delivery (NVD). The primary outcome was the implantation rate. The secondary outcomes included rates of clinical pregnancy, chemical pregnancy, miscarriage, and ectopic pregnancy. Results: The comparison of all fertility outcomes between the two groups revealed no statistically significant differences. The implantation rate was 40.4% in the CD group and 41.7% in the NVD group (p=0.842). The clinical pregnancy rate was 50% in the CD group and 49.3% in the NVD group (p=0.932), while the chemical pregnancy rate was 14.6% in the CD group and 19% in the NVD group (p=0.591). The miscarriage rates in the CD and NVD groups were 20% and 17.6%, respectively (p=0.803). One case of tubal ectopic pregnancy occurred in the NVD group (1.4%). Conclusion: The mode of prior delivery did not significantly impact pregnancy outcomes following frozen-thawed embryo transfer.

      • Teratoma Formation in Immunocompetent Mice After Syngeneic and Allogeneic Implantation of Germline Capable Mouse Embryonic Stem Cells

        Aldahmash, Abdullah,Atteya, Muhammad,Elsafadi, Mona,Al-Nbaheen, May,Al-Mubarak, Husain Adel,Vishnubalaji, Radhakrishnan,Al-Roalle, Ali,Al-Harbi, Suzan,Manikandan, Muthurangan,Matthaei, Klaus Ingo,Mahm Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

        Background: Embryonic stem cells (ESCs) have the potential to form teratomas when implanted into immunodeficient mice, but data in immunocompetent mice are limited. We therefore investigated teratoma formation after implantation of three different mouse ESC (mESC) lines into immunocompetent mice. Materials and Methods: BALB/c mice were injected with three highly germline competent mESCs (129Sv, BALB/c and C57BL/6) subcutaneously or under the kidney capsule. After 4 weeks, mice were euthanized and examined histologically for teratoma development. The incidence, size and composition of teratomas were compared using Pearson Chi-square, t-test for dependent variables, one-way analysis of variance and the nonparametric Kruskal-Wallis analysis of variance and median test. Results: Teratomas developed from all three cell lines. The incidence of formation was significantly higher under the kidney capsule compared to subcutaneous site and occurred in both allogeneic and syngeneic mice. Overall, the size of teratoma was largest with the 129Sv cell line and under the kidney capsule. Diverse embryonic stem cell-derived tissues, belonging to the three embryonic germ layers, were encountered, reflecting the pluripotency of embryonic stem cells. Most commonly represented tissues were nervous tissue, keratinizing stratified squamous epithelium (ectoderm), smooth muscle, striated muscle, cartilage, bone (mesoderm), and glandular tissue in the form of gut- and respiratory-like epithelia (endoderm). Conclusions: ESCs can form teratomas in immunocompetent mice and, therefore, removal of undifferentiated ESC is a pre-requisite for a safe use of ESC in cell-based therapies. In addition the genetic relationship of the origin of the cell lines to the ability to transplant plays a major role.

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        Oscillation of Second-Order Nonlinear Forced Functional Dynamic Equations with Damping Term on Time Scales

        Agwa, Hassan Ahmed,Khodier, Ahmed Mahmoud,Ahmed, Heba Mostaafa Atteya Department of Mathematics 2016 Kyungpook mathematical journal Vol.56 No.3

        In this paper, we establish some new oscillation criteria for the second-order forced nonlinear functional dynamic equations with damping term $$(r(t)x^{\Delta}(t))^{\Delta}+q({\sigma}(t))x^{\Delta}(t)+p(t)f(x({\tau}(t)))=e(t)$$, and $$(r(t)x^{\Delta}(t))^{\Delta}+q(t)x^{\Delta}(t)+p(t)f(x({\sigma}(t)))=e(t)$$, on a time scale ${\mathbb{T}}$, where r(t), p(t) and q(t) are real-valued right-dense continuous (rd-continuous) functions [1] defined on ${\mathbb{T}}$ with p(t) < 0 and ${\tau}:{\mathbb{T}}{\rightarrow}{\mathbb{T}}$ is a strictly increasing differentiable function and ${\lim}_{t{\rightarrow}{\infty}}{\tau}(t)={\infty}$. No restriction is imposed on the forcing term e(t) to satisfy Kartsatos condition. Our results generalize and extend some pervious results [5, 8, 10, 11, 12] and can be applied to some oscillation problems that not discussed before. Finally, we give some examples to illustrate our main results.

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