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Metabolic Syndrome and Male Fertility
Ana Dias Martins,Ahmad Majzoub,Ashok Agawal 대한남성과학회 2019 The World Journal of Men's Health Vol.37 No.2
Metabolic syndrome (MetS) represents a cluster of conditions that have a negative impact on human health overall. Its preva-lence has been rapidly increasing worldwide and has coincided with a global decrease in birth rates and fertility potential. This review aims to address this observation through studying the relationship between MetS and male reproductive health. The effects of obesity, dyslipidemia, hypertension, and insulin resistance on male fertility were examined and supporting evi-dence explaining the pathophysiology of sperm dysfunction with each MetS component were described. Adopting a healthy lifestyle appears to be the single most important intervention to prevent the unwanted effects of MetS on men’s health and fertility. Further studies addressing the components of MetS and their impact on male reproduction are required to enhance our understanding of the underlying pathophysiology and to propose new methods for therapeutic intervention.