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- 저자 : Arun Triyambak Patil (검색결과 1 건)
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Mucoadhesive buccal tablets of domperidone: formulation evaluation and effects of process variables
Suneel Lakshminarayan Pandey,Nilesh Tikaram Hingawe,Ujjalkumar Das,Arun Triyambak Patil 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.2
The aim of the present work was to develop andevaluate buccal adhesive tablets of domperidone and studythe effect of diluents. Tablets were prepared by direct compressionmethod using different polymer and excipientscombinations. Formulations batches were evaluated forphysical parameter, swelling studies, bioadhesion studiesand in vitro drug release. Formulation batch F2 was mostpromising composition of 1:5 ratio of HPMC K4 M/Sodiumalginate. Effect of formulation variables such as diluents i.e. lactose (water soluble) and di-calcium phosphate (DCP)(water insoluble) studied on swelling index, bioadhesiveperformance and in vitro drug release. Bioadhesive force wasdrastically decreased in presence of DCP; it was concludedthat DCP more significantly affected the swelling index thandid lactose. Both Lactose and DCP similarly affect the bioadhesivestrength of buccal adhesive tablets. Dissolutionprofiles have shown non-fickian drug release mechanism,which indicated that the drug was released by diffusion anderosion mechanism. Thereby buccal adhesive tablets offer apromising strategy for drug delivery of domperidone.
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