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        Sedoanalgesia With Midazolam and Fentanyl Citrate Controls Probe Pain During Prostate Biopsy by Transrectal Ultrasound

        Fábio Hissachi Tsuji,Renato Caretta Chambó,Aparecido Donizeti Agostinho,José Carlos Souza Trindade Filho,Carlos Márcio Nóbrega de Jesus 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.2

        Purpose: To assess the pain intensity of patients administered midazolam and fentanylcitrate before undergoing transrectal ultrasound-guided prostate biopsy. Materials and Methods: This was a study in patients with different indications for prostatebiopsy in whom 5 mg of midazolam and 50 μg of fentanyl citrate was administeredintravenously 3 minutes before the procedure. After biopsy, pain was assessed by useof a visual analogue scale (VAS) in three stages: VAS 1, during probe introduction; VAS2, during needle penetration into prostate tissue; and VAS 3, in the weeks followingthe exam. Pain intensity at these different times was tested with stratification by age,race, education, prostate volume, rebiopsy, and anxiety before biopsy. Pain was rankedaccording to the following scores: 0 (no pain), 1–3 (mild pain), 4–7 (moderate pain), and8–10 (severe pain). Statistical analysis was performed by using Kruskal-Wallis andWilcoxon two-tailed tests with a significance of 5%. Results: Pain intensity was not influenced by any risk factors. The mean VAS 1 scorewas 1.95±1.98, the mean VAS 2 score was 2.73±2.55, and the mean VAS 3 score was0.3±0.9, showing greater pain at the time of needle penetration than in other situations(VAS 2>VAS 1>VAS 3, p=0.0013, p=0.0001, respectively). Seventy-five percent of patientsreported a VAS pain scale of less than 3.1 or mild pain. Conclusions: Intravenous sedation and analgesia with midazolam and fentanyl citrateis a good method for reducing pain caused by prostate biopsy, even during probeinsertion.

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