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      • Design of Low Power and Secure Implementation of SBox and Inverse-SBox for AES

        Divya Sharma,Ankur Bhardwaj,Harshita Prasad,Jyoti Kandpal,Abhay Saxena,Kumar Shashi Kant,Gaurav Verma 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.7

        In the cutting edge world, data security has turned into an essential issue furthermore the innovation is going to increment quickly. In this paper, the symmetric key standard for encryption and decoding is propelled Encryption standard (AES). The key stride in the AES is the "S-Box". S Box is an imperative segment for symmetric key calculations. An S-box takes some number of information bits "p" and interprets them in yield bits 'q', where "p" is not as a matter of course equivalent to 'q'. In AES Encryption calculation Sub Bytes change uses S-Box and Inverse S-Box uses Inverse of S-Box. The Sub Bytes substitution is a nonlinear byte substitution that uses substitution table (i.e., S-Box) takes the multiplicative reverse (GF (28)) and infers a relative change to do the Sub Bytes change. Though, converse Sub Bytes Substitution additionally uses gaze upward table (i.e., Reverse S-Box) takes an opposite relative change and after that suggests multiplicative backwards of Galois Field (GF (28)). In this printed material, we investigated substitution table/reverse substitution table, multiplicative opposite and relative change and its converse (i.e. reverse relative change) science in Galois field. A standout amongst the most basic issues in AES is the force utilization. Here, we predominantly centered around the force utilization and in addition security of S-box which is the most power devouring square in the AES. We have executed and reproduced S-Box and Inverse S-Box Lookup table and acquired another improved scrambled Lookup table for more upgraded mystery by utilizing Xilinx Spartan-3 assessment board. The Simulation and execution instruments utilized are Xilinx ISE 14.1i and ModelSim 6.0.

      • Natural History of Patients with Compensated Cirrhosis and a Hepatic Venous Pressure Gradient >20 mm Hg: A Prospective Longitudinal Cohort Study

        ( Aditi Gupta ),( Ankit Bhardwaj ),( Ankur Jindal ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

        Aims: HVPG >10 mm Hg predicts clinical decompensation (CD) in compensated cirrhotics. A few cirrhotics exhibit high HVPG (>20mm Hg) despite no CD. Their natural history, pattern of CD (ascites, hepatic encephalopathy, variceal bleed) and complications (HCC, mortality) is largely unknown. Methods: Consecutive compensated cirrhosis patients with HVPG >5 mm Hg (n=747) were followed up every 3-6 monthly for CD. They were sub-classified at baseline based on HVPG (< 12 mmHg (low HVPG group), 12-20 mmHg (Intermediate HVPG group) and >20 mmHg (High HVPG group). We analyzed only the low and high HVPG groups. Multivariate Logistic regression was used to identify predictors Results: 295(39.4%) patients developed clinical decompensation (CD) at mean follow up of 1.9 ± 0.3 years. In comparison to low HVPG group, first CD in high HVPG group developed early (1.4 ± 0.3 years vs 2 ± 0.3 years, P=0.02), more frequently (ascites- 27.1% vs 13.2%, variceal bleed- 31.9% vs 7.9%, AKI- 31% vs 12.8%, HCC- 12.4% vs. 3.9%; all P<0.05) with higher mortality (15.9% vs 1.9%; P<0.05). There was no significant correlation between baseline HVPG level and grade of esophageal varices (P=0.457). All patients in high HVPG group received carvedilol (maximum dose-25 mg/d, divided) and a repeat HVPG measured after a mean duration of 1.8 ± 0.4 years showed suboptimal HVPG response (≥20% reduction in HVPG or < 12 mmHg) in 26.6% patients (mean HVPG reduction, 3.3± 1.3 mm Hg). Etiology of cirrhosis and grade of varices were not significantly associated with CD or HVPG response. On multivariate analysis, baseline HVPG >20 mm Hg (hazard ratio [HR], 5.09; 95% confidence interval [CI], 2.909-8.926, P=0.001) and high MELD score (HR, 1.125; 95% CI, 1.066- 1.187, P=0.001) were independent predictors of CD. Conclusions: An HVPG of >20mm Hg independently predicts early and more frequent CD in compensated cirrhotics. Only a quarter of these patients respond to carvedilol and hence mandates us for careful HVPG monitoring and low threshold for additional drugs or interventions.

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        Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial

        Manoj Kumar Sharma,Sumeet Kainth,Sachin Kumar,Ankit Bhardwaj,Hemant Kumar Agarwal,Rakhi Maiwall,Kapil Dev Jamwal,Saggere Muralikrishna Shasthry,Ankur Jindal,Ashok Choudhary,Lovkesh Anand,Rajender Mal 대한간학회 2019 Clinical and Molecular Hepatology(대한간학회지) Vol.25 No.2

        Background/Aims: The aim of this study was to study the efficacy and safety of zolpidem for sleep disturbances in patients with cirrhosis. Methods: Fifty-two Child-Turcotte-Pugh (CTP) class A or B cirrhotics with Pittsburgh Sleep Quality Index >5 were randomized to either zolpidem 5 mg daily (n=26) or placebo (n=26) for 4 weeks. Results: The therapy of 4 weeks was completed by 23 patients receiving zolpidem (3 stopped treatment due to excessive daytime drowsiness) and 24 receiving placebo (2 refused to continue the study). In the zolpidem group, after 4 weeks of therapy, there was significant increase in total sleep time (TST) and sleep efficiency compared to baseline and improvement in polysomnographic parameters of sleep initiation and maintenance (i.e., decrease in sleep latency time, decrease in wake time, and decreases in number of arousals and periodic limbs movements per hour of sleep), without any significant change in sleep architecture. Conclusions: Four weeks of 5 mg daily zolpidem in CTP class A or B cirrhosis patients with insomnia led to significant increases in TST and sleep efficiency and improvement in polysomnographic parameters of sleep initiation and maintenance without any significant change in sleep architecture.

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