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      저자 : Amita Verma (검색결과 2 건)
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        In vitro characterization and pharmacodynamic evaluation of furosemide loaded self nano emulsifying drug delivery systems (SNEDDS)

        Pankajkumar Yadav,Ekta Yadav,Amita Verma,Saima Amin 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.6

        Poor water solubility is one of the reasons forerratic absorption after oral administration of furosemide(FSM), an antihypertensive loop diuretic. Self nano emulsifyingdrug delivery system (SNEDDS) is a novel drugdelivery system utilized to improve the water solubility,permeability and ultimately bioavailability. FSM solubilitywas determined in various vehicles oils, surfactants and cosurfactants. Self emulsification region for the rationaldesign of SNEDDS formulations were identified bypseudoternary diagrams. Developed formulations werecharacterized by zeta potential determination, droplet sizeanalysis, dilution test, viscosity determination, in vitrodissolution studies and in vivo pharmacodynamic evaluation. A remarkable increase in dissolution was observed forthe optimized SNEDDS when compared with the plainFSM and marketed formulation by in vitro dissolutionstudies. The pharmacological effect of FSM was improvedby SNEDDS formulation as compared to plain FSM. Thestudy confirmed that the SNEDDS formulation can be usedas a possible alternative to traditional oral formulations ofFSM to improve its bioavailability.

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        Development and statistical optimization of chitosan and eudragit based gastroretentive controlled release multiparticulate system for bioavailability enhancement of metformin HCl

        Atul Kumar Sahu,Amita Verma 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.3

        The present research was intended to develop a gastroretentive controlled release multiparticulate delivery system for a hypoglycemic drug, metformin hydrochloride (MTF) that could efficiently deliver the drug in active form and also increase its systemic bioavailability. In vitro and in vivo evaluations were performed to determine the efficacy of the formulation. MTF loaded microspheres were prepared by W/O/O double emulsion-solvent evaporation method and optimized by 32 full factorial design. The ratio of eudragit RL100 & RS100 (EL:ES) and the chitosan concentration were evaluated as independent variables for dependent variables viz. percent drug release (%DR), percent yield (%Y) and encapsulation efficiency (EE). The morphological characteristics of the microspheres were assessed using scanning electron microscopy which revealed non-aggregated, spherical shape microspheres with rough and rugged surfaces. The particle size range of the formulated microspheres was found to be *74.77–111.18 lm. In vitro drug release best fitted Korsmeyer Peppas release characteristics with Fickian diffusion release mechanism. The optimized batch F1 demonstrated 84.17 ± 5.80 % drug release, 85.47 ± 0.28 % yield and 70.79 ± 0.67 % EE. Optimized batch performed superior pharmacokinetics with prolonged and increased intensity of hypoglycemic effect (87.68 ± 4.9 %) a relative bioavailability of 154.71 % with respect to the marketed product (56.67 ± 4.7 %). These findings highlight the potential of formulated microparticles as a superior candidate for gastro-retentive sustained release delivery of MTF with respect to marketed product.

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