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RISS 인기검색어
- 검색키워드
- 저자 : Alireza H. Tasbiti (검색결과 1 건)
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Abolfazl Fateh,Mohammadreza Aghasadeghi,Seyed D. Siadat,Farzam Vaziri,Farzin Sadeghi,Roohollah Fateh,Hossein Keyvani,Alireza H. Tasbiti,Shamsi Yari,Angila Ataei-Pirkooh,Seyed H. Monavari 질병관리본부 2016 Osong Public Health and Research Persptectives Vol.7 No.2
Objectives: This study aimed to evaluate the specificity, sensitivity, cost, and turn-around time of three methods of gene polymorphism analysis and to study the relationship between IL28B rs12979860 and SVR rate to pegIFN-α/RVB therapy among patients with chronic hepatitis C. Methods: A total of 100 samples from chronic hepatitis C patients were analyzed in parallel using the three methods: direct sequencing, real-time polymerase chain reaction (PCR), amplification refractory mutation system (ARMS)-PCR. Results: The different profiles for IL28B rs12979860 alleles (CC, CT, and TT) obtained with PCR-RFLP, ARMS-PCR, and direct sequencing were consistent among the three methods. Prevalence of rs12979860 genotypes CC, CT and TT in HCV genotype 1a was 10(19.6%), 35(68.6%), and six (11.8%), respectively, and in HCV genotype 31, it was 13(26.5%), 31(63.3%), and five (10.2%), respectively. No significant difference was seen between rs12979860 genotype and HCV genotype (p = 0.710). Conclusion: Screening by ARMS - PCR SNOP detection represents the most efficient and reliable method to determine HCV polymorphisms in routine clinical practice.
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