http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Albert Low (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Darren Chua,Albert Low,Yexin Koh,Brian Goh,Peng Chung Cheow,Juinn Har Kam,Jin Yao Teo,Ek Khoon Tan,Alexander Chung,London Lucien Ooi,Chung Yip Chan,Ser Yee Lee 한국간담췌외과학회 2018 Annals of hepato-biliary-pancreatic surgery Vol.22 No.3
Backgrounds/Aims: Hilar cholangiocarcinomas (HCCAs) are tumors that involve the biliary confluence; at present, radical surgery offers the only chance of long-term survival, but this can be challenging given the complexity of the hilar anatomy. Blumgart and Jarnagin described a preoperative staging system that incorporates the effect of local tumor extent and its impact on adjacent structures and that has been demonstrated to correlate better with actual surgical resectability. The primary aim of this study is to describe the correlation between preoperative Blumgart-Jarnagin staging and its correlation with surgical resectability. Methods: Patients who underwent surgical resection for hilar cholangiocarcinoma at Singapore General Hospital between January 1, 2002, and January 1, 2013, were identified from a prospectively maintained institutional database. All patients were staged based on the criteria described by Blumgart and Jarnagin. Correlation with surgical resectability was then determined. Results: A total of 19 patients were identified. Overall resectability was 57.8% (n=11). Patients with Blumgart-Jarnagin stage T1 had the highest rates of respectability at 80%; patients with stage T2 and T3 disease had resectability rates of 25% and 40% respectively. Median overall survival was 13.6 months. Conclusions: The Blumgart-Jarnagin staging system is useful for predicting tumor respectability in HCCA.
-
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
Koo, Bon-Kyoung,Spit, Maureen,Jordens, Ingrid,Low, Teck Y.,Stange, Daniel E.,van de Wetering, Marc,van Es, Johan H.,Mohammed, Shabaz,Heck, Albert J. R.,Maurice, Madelon M.,Clevers, Hans Nature Publishing Group, a division of Macmillan P 2012 Nature Vol.488 No.7413
LGR5<SUP>+</SUP> stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor signals. Here we find that the related RNF43 and ZNRF3 transmembrane E3 ubiquitin ligases are uniquely expressed in LGR5<SUP>+</SUP> stem cells. Simultaneous deletion of the two genes encoding these proteins in the intestinal epithelium of mice induces rapidly growing adenomas containing high numbers of Paneth and LGR5<SUP>+</SUP> stem cells. In vitro, growth of organoids derived from these adenomas is arrested when Wnt secretion is inhibited, indicating a dependence of the adenoma stem cells on Wnt produced by adenoma Paneth cells. In the HEK293T human cancer cell line, expression of RNF43 blocks Wnt responses and targets surface-expressed frizzled receptors to lysosomes. In the RNF43-mutant colorectal cancer cell line HCT116, reconstitution of RNF43 expression removes its response to exogenous Wnt. We conclude that RNF43 and ZNRF3 reduce Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation.
-
Ma, Rui,Zhang, Huairuo,Yoo, Youngdong,Degregorio, Zachary Patrick,Jin, Lun,Golani, Prafful,Ghasemi Azadani, Javad,Low, Tony,Johns, James E.,Bendersky, Leonid A.,Davydov, Albert V.,Koester, Steven J. American Chemical Society 2019 ACS NANO Vol.13 No.7
<P>The coexistence of metallic and semiconducting polymorphs in transition-metal dichalcogenides (TMDCs) can be utilized to solve the large contact resistance issue in TMDC-based field effect transistors (FETs). A semiconducting hexagonal (2H) molybdenum ditelluride (MoTe<SUB>2</SUB>) phase, metallic monoclinic (1T′) MoTe<SUB>2</SUB> phase, and their lateral homojunctions can be selectively synthesized <I><I>in situ</I></I> by chemical vapor deposition due to the small free energy difference between the two phases. Here, we have investigated, in detail, the structural and electrical properties of <I>in situ</I>-grown lateral 2H/1T′ MoTe<SUB>2</SUB> homojunctions grown using flux-controlled phase engineering. Using atomic-resolution plan-view and cross-sectional transmission electron microscopy analyses, we show that the round regions of near-single-crystalline 2H-MoTe<SUB>2</SUB> grow out of a polycrystalline 1T′-MoTe<SUB>2</SUB> matrix. We further demonstrate the operation of MoTe<SUB>2</SUB> FETs made on these <I>in situ</I>-grown lateral homojunctions with 1T′ contacts. The use of a 1T′ phase as electrodes in MoTe<SUB>2</SUB> FETs effectively improves the device performance by substantially decreasing the contact resistance. The contact resistance of 1T′ electrodes extracted from transfer length method measurements is 470 ± 30 Ω·μm. Temperature- and gate-voltage-dependent transport characteristics reveal a flat-band barrier height of ∼30 ± 10 meV at the lateral 2H/1T′ interface that is several times smaller and shows a stronger gate modulation, compared to the metal/2H Schottky barrier height. The information learned from this analysis will be critical to understanding the properties of MoTe<SUB>2</SUB> homojunction FETs for use in memory and logic circuity applications.</P> [FIG OMISSION]</BR>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
