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RISS 인기검색어
- 검색키워드
- 저자 : Ahmad Tavakoli (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Human parvovirus B19 in patients with beta thalassemia major from Tehran, Iran
Seyed Ali Mohammad Arabzadeh,Farideh Alizadeh,Ahmad Tavakoli,Hamidreza Mollaei,Farah Bokharaei-Salim,Gharib Karimi,Mohammad Farahmand,Helya Sadat Mortazavi,Seyed Hamidreza Monavari 대한혈액학회 2017 Blood Research Vol.52 No.1
Background: Due to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as beta-thalassemia major leads to suppression of erythrocyte formation, referred to as transient aplasia crisis (TAC), which may be life-threatening. We investigated the prevalence of parvovirus B19 among patients with beta thalassemia major attending the Zafar Adult Thalassemia Clinic in Tehran, Iran. Methods: This cross-sectional study was performed to determine the presence of parvovirus B19 DNA in blood samples and parvovirus B19 genotypes in plasma samples of patients with thalassemia major. The population consisted of 150 patients with beta-thalassemia major who attended the Zafar clinic in Tehran. Specimens were studied using a real-time poly-merase chain reaction assay. Results: The prevalence of parvovirus B19 in our study population was 4%. Of 150 patients with thalassemia, six (4%) were positive for B19 DNA. There was no significant correlation between blood transfusion frequency and B19 DNA positivity. Finally, phylogenetic analy-sis of human parvovirus B19 revealed genotype I in these six patients. Conclusion: In this study, acute B19 infections were detected in patients with beta thalassemia major. Screening of such high-risk groups can considerably reduce the incidence and prevalence of B19 infection; thus, screening is required for epidemiologic surveillance and dis-ease-prevention measures.
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Human parvovirus B19 in patients with beta thalassemia major from Tehran, Iran
Seyed Ali Mohammad Arabzadeh,Farideh Alizadeh,Ahmad Tavakoli,Hamidreza Mollaei,Farah Bokharaei-Salim,Gharib Karimi,Mohammad Farahmand,Helya Sadat Mortazavi,Seyed Hamidreza Monavari 대한혈액학회 2017 Blood Research Vol.52 No.1
Background: Due to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as beta-thalassemia major leads to suppression of erythrocyte formation, referred to as transient aplasia crisis (TAC), which may be life-threatening. We investigated the prevalence of parvovirus B19 among patients with beta thalassemia major attending the Zafar Adult Thalassemia Clinic in Tehran, Iran. Methods: This cross-sectional study was performed to determine the presence of parvovirus B19 DNA in blood samples and parvovirus B19 genotypes in plasma samples of patients with thalassemia major. The population consisted of 150 patients with beta-thalassemia major who attended the Zafar clinic in Tehran. Specimens were studied using a real-time poly-merase chain reaction assay. Results: The prevalence of parvovirus B19 in our study population was 4%. Of 150 patients with thalassemia, six (4%) were positive for B19 DNA. There was no significant correlation between blood transfusion frequency and B19 DNA positivity. Finally, phylogenetic analy-sis of human parvovirus B19 revealed genotype I in these six patients. Conclusion: In this study, acute B19 infections were detected in patients with beta thalassemia major. Screening of such high-risk groups can considerably reduce the incidence and prevalence of B19 infection; thus, screening is required for epidemiologic surveillance and dis-ease-prevention measures.
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Human parvovirus B19 and parvovirus 4 among Iranian patients with hemophilia
Davod Javanmard,Masood Ziaee,Hadi Ghaffari,Mohammad Hasan Namaei,Ahmad Tavakoli,Hamidreza Mollaei,Mohsen Moghoofei,Helya Sadat Mortazavi,Seyed Hamidreza Monavari 대한혈액학회 2017 Blood Research Vol.51 No.4
Background: Human parvovirus B19 (B19V) is one of the smallest DNA viruses and shows great resist-ance to most disinfectants. Therefore, it is one of the common contaminant pathogens present in blood and plasma products. Parvovirus 4 (PARV4) is a newly identified parvovi-rus, which is also prevalent in parenteral transmission. In this study, we aimed to evaluate the prevalence of B19V and PARV4 DNA among patients with hemophilia in Birjand County in eastern Iran. Methods: This was a cross-sectional epidemiological study comprising nearly all people with hemo-philia in this region. Whole blood samples were taken after patient registration and sent for plasma isolation. After nucleic acid extraction, B19V was detected with real-time poly-merase chain reaction, PARV4 DNA was then detected using sensitive semi-nested PCR. Results: In total, there were 86 patients with hemophilia, with mean age 28.5±1.5 years. Of these, 90.7% were men and 9.3% women; 84.9% had hemophilia A and 7.0% had hemophilia B. We found 11 patients (12.8%) were positive for B19V DNA and 8 were positive (9.3%) for PARV4 DNA. The prevalence of B19V was higher in middle-aged groups rather than younger people, whereas PARV4 infection was more common in younger patients (P<0.05). Conclusion: There was a high prevalence of B19V and PARV4 infection in this high-risk group of pa-tients with hemophilia. Due to the clinical significance of the B19 virus, imposing more precautionary measures for serum and blood products is recommended.
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Human parvovirus B19 and parvovirus 4 among Iranian patients with hemophilia
Davod Javanmard,Masood Ziaee,Hadi Ghaffari,Mohammad Hasan Namaei,Ahmad Tavakoli,Hamidreza Mollaei,Mohsen Moghoofei,Helya Sadat Mortazavi,Seyed Hamidreza Monavari 대한혈액학회 2017 Blood Research Vol.52 No.4
Background: Human parvovirus B19 (B19V) is one of the smallest DNA viruses and shows great resist-ance to most disinfectants. Therefore, it is one of the common contaminant pathogens present in blood and plasma products. Parvovirus 4 (PARV4) is a newly identified parvovi-rus, which is also prevalent in parenteral transmission. In this study, we aimed to evaluate the prevalence of B19V and PARV4 DNA among patients with hemophilia in Birjand County in eastern Iran. Methods: This was a cross-sectional epidemiological study comprising nearly all people with hemo-philia in this region. Whole blood samples were taken after patient registration and sent for plasma isolation. After nucleic acid extraction, B19V was detected with real-time poly-merase chain reaction, PARV4 DNA was then detected using sensitive semi-nested PCR. Results: In total, there were 86 patients with hemophilia, with mean age 28.5±1.5 years. Of these, 90.7% were men and 9.3% women; 84.9% had hemophilia A and 7.0% had hemophilia B. We found 11 patients (12.8%) were positive for B19V DNA and 8 were positive (9.3%) for PARV4 DNA. The prevalence of B19V was higher in middle-aged groups rather than younger people, whereas PARV4 infection was more common in younger patients (P<0.05). Conclusion: There was a high prevalence of B19V and PARV4 infection in this high-risk group of pa-tients with hemophilia. Due to the clinical significance of the B19 virus, imposing more precautionary measures for serum and blood products is recommended.
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