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Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation
Abid Oueslati,Methodios Ximerakis,Kostas Vekrellis 한국뇌신경과학회 2014 Experimental Neurobiology Vol.23 No.4
Converging lines of evidence suggest that cell-to-cell transmission and the self-propagation of pathogenic amyloidogenic proteinsplay a central role in the initiation and the progression of several neurodegenerative disorders. This “prion-like” hypothesis hasbeen recently reported for α-synuclein, a presynaptic protein implicated in the pathogenesis of Parkinson’s disease (PD) and relateddisorders. This review summarizes recent findings on α-synuclein prion-like propagation, focusing on its transmission, seeding anddegradation and discusses some key questions that remain to be explored. Understanding how α-synuclein exits cells and propagatesfrom one brain region to another will lead to the development of new therapeutic strategies for the treatment of PD, aiming atslowing or stopping the disease progression.