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Londonkar, Ramesh,Kamble, Abhaykumar 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4
The present study was carried out to evaluate the antioxidant effect of methanol extract of $Pandanus$ $odoratissimus$ lim (MEPO) leaf in wistar albino rats. The animals were grouped differently and administered with Carbon tetrachloride ($CCl_4$) (1.5/$kg^{-1}$ $CCl_4$ 1 ml $kg^{-1}$ in liquid paraffin 3 doses (i.p) at 72 h interval). The extracts at the doses of 50 and 100 mg $kg^{-1}$ and Liv 52 25 mg $kg^{-1}$ were administered to the $CCl_4$ treated rats. The effect of extract and Liv 52 on serum transaminase (GOT, GPT), alkaline phosphatease (ALP), bilirubin and total protein were measured in the rat induced by $CCl_4$. The effect of extract on lipid peroxidation (LPO), Superoxide Dismutase (SOD), Catalase (CAT), Glutathione (GSH) and Vitamin E were estimated. The extract and Liv 52 produced significant ($P$ <0.05) effect by decreasing the activity of serum enzymes, bilirubin, uric acid and lipid peroxidation and significantly ($P$ <0.05) increased in the level of SOD, CAT, GSH, Vitamin E and protein. Hence these results suggest that Methanolic extract of Pandanus odoratissimus has potent antioxidant properties.
Ramesh Londonkar,Abhaykumar Kamble 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4
The present study was carried out to evaluate the antioxidant effect of methanol extract of Pandanus odoratissimus lim (MEPO) leaf in wistar albino rats. The animals were grouped differently and administered with Carbon tetrachloride (CCl_4) (1.5/kg^(−1) CCl_4 1 ml kg^(−1) in liquid paraffin 3 doses (i.p) at 72 h interval). The extracts at the doses of 50 and 100 mgkg^(−1) and Liv 52 25 mg kg^(−1) were administered to the CCl_4 treated rats. The effect of extract and Liv 52 on serum transaminase (GOT, GPT), alkaline phosphatease (ALP), bilirubin and total protein were measured in the rat induced by CCl_4. The effect of extract on lipid peroxidation (LPO), Superoxide Dismutase (SOD), Catalase (CAT), Glutathione (GSH) and Vitamin E were estimated. The extract and Liv 52 produced significant (P<0.05) effect by decreasing the activity of serum enzymes, bilirubin, uric acid and lipid peroxidation and significantly (P<0.05)increased in the level of SOD, CAT, GSH, Vitamin E and protein. Hence these results suggest that Methanolic extract of Pandanus odoratissimus has potent antioxidant properties.