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흰쥐 뇌에 분포하는 MHC Class II 양성 면역반응 수지상세포의 연령에 따른 변화
양필순(Pil Soon Yang),황규근(Kyu Geun Hwang),유기수(Ki Soo Yoo) 대한소아신경학회 2002 대한소아신경학회지 Vol.10 No.1
목적: 항원제공세포인 MHC Class II 양성 면역반응성 수지상세포를 두개강내에 투여하여 종양을 치료하는 방법이 제시되어 수지상세포에 대한 관심이 고조되고 있다. 그러나 정상 뇌에서 수지상세포의 분포 상태 뿐만 아니라 연령에 따른 세포수 및 형태의 변화에 대해서도 보고된 바 없는 실정이다. 그러므로 본 연구자는 연령에 따른 세포수 및 형태학적인 변화를 구명할 목적으로 이 연구를 시도하였다. 방법: 생후 1개월, 12개월, 및 24개월 된 흰쥐의 뇌를 적출하여 냉동 연속조직절편을 제작한 다음 면역조직화학적 염색을 시행한 뒤 MHC Class II 양성 면역반응성 수지상세포를 관찰하고 계수하였다. 결과: 1)MHC Class II 양성 면역반응 수지상세포는 맥락막총과 백색질에서 관찰되었다. 2)나이가 많아짐에 따라 수지상세포는 증가되었다. 3)연령이 증가함에 따라 수지상세포는 세포질돌기의 분지양상은 더욱 복잡해졌고, 일부 세포들은 군집을 이루었다. 결론: 연령이 증가함에 따라 맥락막총 및 백색질에 분포하는 수지상 세포들은 수적으로 증가할 뿐만 아니라 세포질돌기도 복잡해져 면역반응성을 증대시키는 결과를 초래할 것으로 추측된다. PURPOSE: Dendritic cells are antigen presenting cells(APC) that express class II major histocompatibility complex gene products on their surface. Recently, it was proved that dendritic cells activate antitumor immunity for intracranial germ cell tumor. The aim of the present study is to investigate the age-related changes of MHC class II-immunoreactive dendritic cells in the rat brain. METHODS: Male rats(Sprague-Dawley) were sacrificed at 1 month, 12 months and 24 months after birth. Brains were removed and sliced in rat brain matrix. Brain slices were cryosectioned coronally at interaural 5.70-6.70 mm. Brain tissue sections were immunohistochemically reacted with monoclonal MHC class II antibody. RESULTS: MHC class II-immunoreactive dendritic cells were observed in choroid plexuses and white matter(corpus callosum, cerebral peduncle and external capsule). The number of MHC class II-immunoreactive dendritic cells was slightly increased with age. As age increases, shapes of MHC class II-immunoreactive dendritic cells became more complex and aggregated together. CONCLUSION: As age increases, MHC class II-immunoreactive dendritic cells in choroid plexuses and white matter of the brain became not only more complex in shape, but also increased in number to improve immunity.
Sleep Duration and Mental Health among Korean Adults Population
김재현,양정민,유기봉 융합연구학회 2022 융합연구학회지 Vol.6 No.2
The purpose of this study was to investigate the association between Weekday and weekend sleep duration and perceived stress and suicidal ideation. Data was obtained by the Korea National Health and Nutrition Examination Survey seventh (2017) using a rolling sampling design involving a complex, stratified, multistage, and probability-cluster survey of civilian non-institutionalized Korean residents. We conducted a cross-section study of a total of 5,818 subjects (2,579 males and 3,239 females) who were aged 18 years and older. We found that the odds of poor perceived stress in groups with weekday sleep duration of six hours or less was 1.348 times higher (p-value: 0.001) than that in groups with sleep duration of 7-8 hours on weekday. The odds of suicidal ideation in groups with weekend sleep duration of six hours or less was 1.682 times higher (p-value: 0.029) than that in groups with sleep duration of 7-8 hours on weekend. Poor sleep duration appears to be closely associated with poor perceived stress and suicidal ideation. Based on the findings of our study, effective prevention and intervention programs should be established with improving their awareness of the serious consequences of sleep problems educating reasonable working time and pay close attention to those who have poor perceived stress and suicidal ideation.