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아토피피부염 환자에서 소아와 성인의 MAST CLA 검사에 의한 혈청 총 IgE 검사와 알레르겐 특이항체 검사 성적의 평가
김형동 ( Hyung Dong Kim ),조문균 ( Moon Kyun Cho ),이성열 ( Sung Yul Lee ),이종석 ( Jong Suk Lee ),박영립 ( Young Lip Park ),황규왕 ( Kyu Uang Whang ),황보영 ( Bo Young Hwang ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.5
Background: The multiple allergosorbent test chemiluminescent assay (MAST-CLA) system is a simple method for measuring total and allergen-specific IgE antibodies in the serum of patients with atopic dermatitis. Total IgE, however, is much frequently higher, even if no allergen-specific IgE antibodies can be detected in serum. Objective: The purpose of this study was to evaluate total IgE class, the allergen frequencies and their correlations in MAST-CLA in child and adult atopic dermatitis patients respectively. Methods: A total of fifty two adult patients and ninety child patients with atopic dermatitis were evaluated by MAST-CLA between march 2002 and march 2005 at Soonchunhyang hospital. Positive rates of specific IgE and the total serum IgE level of the MAST-CLA allergy system were compared between child and adult patients. Results: Among the subjects, 84.5% (80.0% for child patients and 92.3% for adult patients) of patients showed an elevated serum total IgE (more than class level 2) and 54.9% (45.6% for child patients, 71.2% for adult patients) revealed at least more than one allergen-specific IgE by MAST-CLA. The average 3.76 (3.39 for child patients, 4.16 for adult patients) different allergens was simultaneously detected in a single positive serum. Commonly-positive allergen rates, in descending order, were D. farinae 44.4%, D. pteronyssynos 38.7% and house dust 26.8%. Furthermore, the higher total serum IgE level in adult patients, the more probability of allergen-specific IgE positive results being disclosed (p<0.05). The number of allergen-specific IgE positive results was increased in a higher serum total IgE level (p<0.05). But total IgE positive rates which had allergen-specific antibody negative patients was 37.5% (45.8% for child patients, 25.0% for adult patients). Good correlation was obtained between total IgE levels and number of positive allergen-specific IgE in MAST-CLA, with 0.551 correlation coefficiency (p<0.05). Conclusion: Our study suggested that the MAST-CLA allergy system is a useful screening test to detect allergenspecific IgE and to evaluate patients with atopic dermatitis. But other allergen screening tests should be used for detecting allergens, when MAST-CLA total IgE class is increased over class 2 with no detectable specific IgE. (Korean J Dermatol 2007;45(5):413~421)
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최성연 ( Sung Youn Choi ),박동일 ( Dong Il Park ),이창균 ( Chang Kyun Lee ),차재명 ( Jae Myung Cha ),이석호 ( Suck Ho Lee ),황보영 ( Bo Young Whang ),은창수 ( Chang Soo Eun ),한동수 ( Dong Soo Han ),이보인 ( Bo In Lee ),신정은 ( J 대한소화기학회 2014 대한소화기학회지 Vol.63 No.1
목적: 선종 발견율을 대신하여 용종 발견율이 대장내시경의 질관리 지표로서 제시된 바 있다. 이번 연구에서는 결장의 구역별로 용종 발견율과 선종 발견율을 비교하여 일치도를 분석하여 특정구역의 용종 발견율이 선종 발견율을 대신하여 대장 내시경 질 관리 지표로 사용될 수 있는지 알아보고자 하였다. 대상 및 방법: 2010년 5월부터 2011년 2월까지 6개의 대학병원에서 20명의 내시경 의사가 시행한 40세 이상 무증상군을 대상으로 한 대장내시경 1,937건을 내시경 소견과 진료 기록, 병리학적 결과지를 조사하여 후향적으로 분석하였다. 용종 발견율과 선종 발견율은 용종이나 선종이 있던 환자수를 전체대장내시경 수로 나눈 값으로 하였고 결장의 각 구역별로 분석하였다. 결과: 총 1,937예의 내시경을 대상으로 분석하였다. 대상군의 나이는 평균 55.4세(range, 40-84세)였고, 남자는 전체 대상자의 55.7%였다. 용종 발견율은 49.9%, 선종 발견율은 36.6%, 진행성 선종 발견율은 5.8%였다. 용종 발견율, 선종발견율과 진행성 선종 발견율은 남성에서 각각 41.6%, 31.2%, 5.2%였고, 여성에서는 각각 40.1%, 28.2%, 3.9%였다. 근위부 결장에서는 구역별로 용종 발견율과 선종 발견율 이 유사하였고(kappa value=0.917), 원위부 결장에서는 구불결장과 곧창자에서 용종 발견율이 유의하게 높았다(p=0.006, <0.001). 결론: 대장내시경의 질 관리 지표로서 용종 발견율을 사용할 때에는 결장의 구역별로 용종 발견율을 계산하여야 하며 근위부 결장의 용종 발견율은 선종 발견율을 대신하여 대장내시경질 관리 지표가 될 수 있을 것이다. Background/Aims: The polyp detection rate (PDR) has been suggested as a surrogate for adenoma detection rate (ADR). The purpose of this study was to determine the level of agreement between PDR and ADR in the proximal and distal colon. Methods: A total of 1,937 consecutive, asymptomatic individuals aged 40 years and older who underwent colonoscopies at six academic teaching hospitals in Korea were included in this study. PDR and ADR were calculated for each colonic segment. PDR was compared with ADR in the proximal and distal colon. Results: During 1,937 colonoscopies, 1,862 polyps were removed; 1,421 (76%) were adenomas. The PDR and ADR in the proximal colon was 25.8% and 22.8%, respectively (kappa value=0.917, p=0.26), and that in the distal colon was 28.9% and 22.2%, respectively (p<0.001). There was a strong correlation between PDR and ADR in the proximal colon, but diverged in sigmoid colon and rectum. Conclusions: PDR and ADR correlate well in the proximal colon, but not in the distal colon, especially sigmoid and rectum. PDR should be measured for each colonic segment when using PDR as a surrogate for ADR. PDR is a valid proxy for ADR in the proximal colon. (Korean J Gastroenterol 2014;63:11-17)
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Palladium 을 이용한 Phenylacetylene 의 Hydrosilylation
박용성,우제완,안보영,황영애 한국공업화학회 2000 응용화학 Vol.4 No.2
Silylstyrenes were prepared by the hydrosilylation reaction of acetylene with alkylsilane using palladium(II) nitrate catalyst in the presence of various sulfides as ligands in toluene. The selectivity of product catalyzed by palladium complex was found to be higher than that catalyzed by previously reported Lewis acid. The effect of the ligands on the yield has been investigated. Sulfides containing less basic substituents increase the yield of product.
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