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가와사키병의 관상동맥 이상과 TLR2 유전자의 단일염기다형성
홍승수 외 중앙대학교 의과대학 의과학연구소 2009 中央醫大誌 Vol.34 No.3/4
Purpose: Many gene polymorphisms are associated with coronary artery abnormality in Kawasaki disease (KD). Toll like receptors (TLRs) are known to be involved in innate immunity. TLRs recognize structurally conserved molecules derived from microbes. Once these microbes have breached physical barriers such as the skin or intestinal tract mucosa, they are recognized by TLRs which activate immune responses. They activate nuclear factor-κB which produces diverse inflammatory cytokines. Polymorphism of TLR2 gene is reported to be associated with coronary artery abnormalities. The aim of this study was to evaluate the relationship between TLR2 polymorphism and coronary artery abnormality in Kawasaki disease. Methods: One hundred and one Korean children with Kawasaki disease and three hundred and six Korean healthy controls were enrolled in this study. The polymorphism of TLR2 gene was analyzed by direct sequencing. Results: There were no differences in the genotype (p =0.78) and allelic frequency (p =0.91) of the TLR2 rs3804099 and rs3804100 between KD and control subjects. There was no significant difference in TLR2 rs3804099 and rs3804100 polymorphism between patients with coronary artery lesion (CAL) and those without CAL. Conclusion: These results indicate that the polymorphisms of rs3804099 and rs3804100 in TLR2 gene might be not related in the development of coronary artery abnormalities in Kawasaki disease.
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