임신중독증 환자에서 생긴 비전형적인 용혈성요독증후군 1예

현혜선,이나혜,심현진,이미라,문성택,전섭,최승도,선우재근,배동한,김윤숙 대한산부인과학회 2011 대한산부인과학회 학술대회 Vol.97 No.-

p-Cresyl sulfate and indoxyl sulfate in pediatric patients on chronic dialysis

현혜선,백경훈,조희연 대한소아청소년과학회 2013 Clinical and Experimental Pediatrics (CEP) Vol.56 No.4

Purpose: Indoxyl sulfate and p- cresyl sulfate are important protein-bound uremic retention solutes whose levels can be partially reduced by renal replacement therapy. These solutes originate from intestinal bacterial protein fermentation and are associated with cardiovascular outcomes and chronic kidney disease progression. The aims of this study were to investigate the levels of indoxyl sulfate and p- cresyl sulfate as well as the effect of probiotics on reducing the levels of uremic toxins in pediatric patients on dialysis. Methods: We enrolled 20 pediatric patients undergoing chronic dialysis; 16 patients completed the study. The patients underwent a 12-week regimen of VSL#3, a high-concentration probiotic preparation, and the serum levels of indoxyl sulfate and p- cresyl sulfate were measured before treatment and at 4, 8, and 12 weeks after the regimen by using fluorescence liquid chromatography. To assess the normal range of indoxyl sulfate and p- cresyl sulfate we enrolled the 16 children with normal glomerular filtration rate who had visited an outpatient clinic for asymptomatic microscopic hematuria that had been detected by a school screening in August 2011. Results: The baseline serum levels of indoxyl sulfate and p- cresyl sulfate in the patients on chronic dialysis were significantly higher than those in the children with microscopic hematuria. The baseline serum levels of p- cresyl sulfate in the peritoneal dialysis group were significantly higher than those in the hemodialysis group. There were no significant changes in the levels of these uremic solutes after 12-week VSL#3 treatment in the patients on chronic dialysis. Conclusion: The levels of the uremic toxins p- cresyl sulfate and indoxyl sulfate are highly elevated in pediatric patients on dialysis, but there was no significant effect by probiotics on the reduction of uremic toxins in pediatric dialysis patients. Therefore, studies for other medical intervention to reduce uremic toxins are also necessary in pediatric patients on dialysis.

중학생의 인지 양식에 따른 과학 수업에서 제작한 인포그래픽 유형과 인포그래픽 활용 과학 수업에 대한 인식

현혜선,노아름,이수경,최혁준 한국교원대학교 뇌기반교육연구소 2022 Brain, Digital, & Learning Vol.12 No.2

The purpose of this study is to examine the types of infographics made in science classes and perceptions of science classes using infographics according to the cognitive styles of middle school students. To this end, the group Embedded Figures test was conducted on 106 second-year middle school students, and 21 the field-independent type and 30 the field-dependent type were selected as the study subjects. The science class using infographics consisted of a total of 20 classes. The class consisted of an introduction to infographics and an orientation stage on how to create infographics, infographics understanding stage to identify infographics materials related to the class topic, and a stage to create infographics using a production tool. The students' perception of the class after science class using infographics was investigated, and the types of infographics produced by the students were analyzed according to the cognitive style. The study results are as follows. First, among the types of infographics produced by students, there was no significant relationship between the visual expression type and the cognitive style, but there was a correlation between the construction method and the cognitive style. the field- independent students used simple reconstruction, relocation, and reorganization methods to find and apply more information than the field-independent students. Second, there was a difference in the perception of science class using infographics according to the cognitive style. In all areas such as the effect of using infographics, difficulties in creating infographics, whether other science subjects were used, activity and interest, etc., the field-independent students perceived more positively about classes using infographics than the field-dependent students. Based on this study suggest that science classes using infographics should design teaching and learning plans suitable for the field-independent and field-dependent students, and that more systematic instruction and guidance are needed, especially for effective infographics use classes for students with the field-dependence.

Post-Transplant Lymphoproliferative Diseases in Pediatric Kidney Allograft Recipients with Epstein-Barr Virus Viremia

현혜선,박유진,조명현,민상일,하종원,강형진,신희영,하일수,정해일,안요한,강희경 대한의학회 2019 Journal of Korean medical science Vol.34 No.30

Background: Post-transplant lymphoproliferative disease (PTLD) is one of the major complications of organ transplantation, especially in children with Epstein-Barr virus (EBV) viremia (EV). We performed a retrospective study to evaluate risk factors for PTLD in children with EV. Methods: Among 199 pediatric kidney transplantation (KT) recipients at our center from January 2001 to October 2015, records of those with EBV viral loads of > 1,000 copies/mL and/ or PTLD were reviewed. Results: Diagnosis of PTLD was made in seven patients (PTLD group), and 39 patients had EV only (EV only group). The median time from KT to EV and PTLD diagnosis was 6.7 (range 0.4–47.8) months and 8.2 (range, 2.8–98.9) months, respectively. There were no significant differences between the groups in terms of sex, age at transplantation, donor type, EBV viral load, or EV-free duration after KT. Higher tacrolimus level before EV (hazard ratio, 44.5; P = 0.003) was an independent risk factor for PTLD in multivariate Cox regression analysis. Six patients with a high EBV load (median 171,639 copies/mL) were treated with preemptive rituximab (RTX) therapy, resulting in transient reduction of EBV load. None of these patients developed PTLD (median follow-up 51.5 months); however, two had neutropenia and two developed infection requiring hospital admission. Conclusion: In pediatric KT recipients, higher tacrolimus levels were associated with a higher incidence of PTLD. Conversely, those who received preemptive RTX for EV did not develop PTLD.

A Case of Severe Hypercalcemia Causing Acute Kidney Injury: An Unusual Presentation of Acute Lymphoblastic Leukemia

현혜선,박평강,김재춘,홍균택,강형진,박경덕,신희영,강희경,하일수,정해일 대한소아신장학회 2017 Childhood kidney diseases Vol.21 No.1

Severe hypercalcemia is rarely encountered in children, even though serum calcium concentrations above 15-16 mg/dL could be life-threatening. We present a patient having severe hypercalcemia and azotemia. A 14-year-old boy with no significant past medical history was referred to our hospital with hypercalcemia and azotemia. Laboratory and imaging studies excluded hyperparathyroidism and solid tumor. Other laboratory findings including a peripheral blood profile were unremarkable. His hypercalcemia was not improved with massive hydration, diuretics, or even hemodialysis, but noticeably reversed with administration of calcitonin. A bone marrow biopsy performed to rule out the possibility of hematological malignancy revealed acute lymphoblastic leukemia. His hypercalcemia and azotemia resolved shortly after initiation of induction chemotherapy. Results in this patient indicate that a hematological malignancy could present with severe hypercalcemia even though blast cells have not appeared in the peripheral blood. Therefore, extensive evaluation to determine the cause of hypercalcemia is necessary. Additionally, appropriate treatment, viz., hydration or administration of calcitonin is important to prevent complications of severe hypercalcemia, including renal failure and nephrocalcinosis.

46,X,dup(Xq) 환자에서의 드문 조기난소부전 1예(초)

현혜선,김미영,김윤숙,문성택,전섭,선우재근,배동한 대한산부인과학회 2009 대한산부인과학회 학술대회 Vol.95 No.-

에듀테크를 활용한 무용 기능 해부학 프로그램 개발

현혜선 ( Hye Seon Hyun ),문영 ( Young Moon ) 대한무용학회 2021 대한무용학회논문집 Vol.79 No.3

Dance education is still at its nascent stage, especially in terms of applicability of edutech, and the adoption of professional dance educational contents and programs using edutech is still low. In this context, this study explores the potential applicability of educational contents using ICT (edutech) in the fields of dance education - more specifically, in terms of development of professional dance educational contents such as functional anatomy for dance. This study also explores the effectiveness of development of professional dance educational contents using edutech. The key implication of this study is that it has laid the groundwork for the actual application of dance educational contents using edutech - it will enable a shift towards a learner-centered environment from a traditional teacher-centered environment, and experiential learning driven by learner’s interest will improve the effectiveness of learning in the fields of dance education. The author hopes that this study will lead to further studies and developments of dance education using edutech, which would contribute to a new learning and education model in dance education.

복압성 요실금을 가진 폐경 여성의 요역동학적 검사의 특성: 폐경 전과 폐경 후 여성들에서 후향적 비교연구

현혜선 ( Hye Sun Hyun ),박보라 ( Bo Ra Park ),김윤숙 ( Yun Sook Kim ),문성택 ( Seung Taek Mun ),배동한 ( Dong Han Bae ) 대한폐경학회 2010 대한폐경학회지 Vol.16 No.3

연구목적: 요실금을 호소하여 병원에 내원하여 복압성 요실금으로 진단받은 여성에서 폐경 전과 폐경 후에 요역동학적 검사에서의 차이점을 비교하여 복압성 요실금을 가진 폐경 후 여성의 요역동학적 특성을 알아보고자 하였다. 연구재료 및 방법: 복압성 요실금으로 진단된 40명의 폐경 전 여성과 44명의 폐경 후 여성을 임의적으로 선택하였다. 자세한 병력청취와 부인과적인 검진, 소변검사와 방광내압측정, 요도내압측정, 요속측정을 포함한 요역동학 검사를 시행하여 비교하였다. 결 과: 두 군 간의 체질량지수 (body mass index)는 차이가 없었다. 폐경 후 여성의 평균나이는 62.1 ± 9.4세, 폐경전 여성은 40.9 ± 6.4세였다. 발살바 요누출압은 폐경 후 여성이 폐경 전 여성보다 낮았다 (88.2 ± 25.1 vs 106.4 ± 30.3 cmH2O, P=0.04). 최대 요도 폐쇄압은 폐경 후 여성이 폐경 전 여성보다 낮았다 (44.9 ± 21.4 vs 77.4 ± 32.2 cmH2O, P<0.001). 기능성요도길이는 폐경 후 여성이 폐경 전 여성보다 더 짧았다 (29.0 ± 9.7 vs 36.9 ± 10.9 mm, P=0.003). 최대 요속이나 잔뇨량, 최대 방광용적, Q-Tip test는 두 군 간의 차이가 없었다. 출산횟수는 폐경 후 여성이 더 많았다 (2.8 vs 2.2, P=0.026). 결론: 우리 연구의 결과는 발살바 요누출압과 최대 요도 폐쇄압은 폐경 후 여성이 더 낮고, 기능성요도길이는 폐경후 여성이 더 짧았다. 하지만 출산횟수나 질식자연분만 횟수가 폐경 후 여성이 더 많았다. 그리고 폐경과 무관한 나이에 대한 노화과정인지 아니면 폐경이 원인인지 구분이 모호하다. 그러므로 이 변수에 대해 좀 더 연구가 필요할 것으로 생각된다. Objectives: To compare the urodynamic characteristics between pre- and post-menopausal women with stress urinary incontinence. Methods: Forty premenopausal women and 44 postmenopausal women with stress urinary incontinenece were enrolled. All of the patients underwent a detailed history, gynaecologic examination, urinalysis and urodynamics including cystometry and pressure-flow analysis. Results: There was no difference in the body mass index between the two groups. The mean age of pre- and post-menopausal women was 40.9 ± 6.4 years and 62.1 ± 9.4 years, respectively. The parity in postmenopausal women was greater than premenopausal women (2.8 ± 1.2 vs 2.2 ± 0.8, P=0.026). The valsalva leak point pressure (VLPP) in postmenopausal women was lower than that in premenopausal women (106.4 ± 30.3 vs 88.2 ± 25.1 cmH2O, P=0.04). The maximal urethral closure pressure (MUCP) in postmenopausal women was lower than premenopausal women (44.9 ± 21.4 vs 77.4 ± 32.2 cmH2O, P<0.001). The functional urethral length (FUL) in postmenopausal women was shorter than it in premenopausal women (29.0 ± 9.7 vs 37.0 ± 10.9 mm, P=0.003). There were no significant statistical differences in maximal flow rate, residual urine, maximal bladder capacity and Q tip test. Conclusion: The VLPP and MUCP were lower, and the FUL was shorter in postmenopausal women with stress urinary incontinence than premenopausal women. The parity and number of vaginal deliveries were different between the two groups. Further investigation will be needed concerning these variables. (J Korean Soc Menopause 2010;16:148-152)

46,X,dup(Xq) 환자에서의 드문 조기난소부전

현혜선 ( Hye Sun Hyeon ),박보라 ( Bo Ra Park ),김윤숙 ( Yun Sook Kim ),문성택 ( Seong Taek Mun ),전섭 ( Seob Jeon ),선우재근 ( Jae Gun Sunwoo ),배동한 ( Dong Han Bae ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.8

Premature ovarian failure (POF) is defined as the complete cessation of menses less than 40 years of age. The criteria are more than four months of amenorrhea, with serum follicle stimulating hormone value of >40 mIU/mL and the frequency of POF is about 1% of all women. Although the etiologies of POF remain unknown, suggested factors are genetic, autoimmune, chemotherapy, radiotherapy and environmental toxins. The cytogenetic abnormalities predominantly concern the X chromosome, including Turner syndrome, Fragile X syndrome and deletion, translocation, or duplication of X chromosome. We report a very rare case of premature ovarian failure with the following karyotype: 46,X,dup(Xq), and report it with a brief review of literature.

VR(Virtual Reality)을 활용한 무용 교육 콘텐츠 적용 가능성 연구

현혜선 ( Hye-seon Hyun ) 대한무용학회 2020 대한무용학회논문집 Vol.78 No.6

The purpose of the study is to explore the applicability of VR (virtual reality) education contents for dance education, and to assess the feasibility of developing dance education contents using VR to enhance the effectiveness of dance education. While VR education is being widely introduced across the various fields, but within dance domain, VR is partially used only in dance performances but not in the areas of dance education. Thus, it is important to do case studies of VR education in other areas to expand its applicability to dance education. This study has reviewed the characteristics of VR education, and performed in-depth analysis on various VR education contents as well as dance education contents to highlight the applicability of VR dance education. The study shows that VR has enhanced the learning experience and thus improved the effectiveness of education by stimulating learner's interest and by maximizing immersive effects during the classes. The study also has found that VR education can be applicable in the various fields of dance education including basic dance classes, choreography classes, repertory classes and dance theory classes. Futhermore, it would be critical to develop VR education contents specifically tailored to dance education, and to train VR dance education experts.