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화장품에서 약물전달 기술의 응용에 관한 동향 및 최신기술 리뷰
조희경(Heui-Kyoung Cho),홍우진(Woo-Jin Hong),한현탁(Hyun-Tak Han) 한국화장품미용학회 2016 한국화장품미용학회지 Vol.6 No.2
Recently a variety of drug delivery system (DDS) have been explored and some of them are clinically used to deliver therapeutic drugs through skin. In topical delivery, the polymer based DDS as drug carrier should guarantee non-toxicity, long-term stability, and permeation efficacy for drugs, etc. For the development of the successful topical delivery system, it is of importance to develop the polymeric vehicles of well-defined intrinsic properties, such as molecular weights, HLB, chemical composition, topology, specific ligand conjugation and to investigate the effects of the properties on drug permeation behavior. In addition, the role of polymeric vehicles must be elucidated in in vitro and in vivo analyses. This article describes a kinds of theories and studies for skin permeation and some important features of polymer based DDS in topical delivery. Even though the application span of polymers has been truly broad in the cosmetic and pharmaceutical fields.
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