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만성 정신분열증 환자에서 Paroxetine과 Haloperidol 병합투여시 정신병리증상과 Haloperidol, Reduced Haloperidol 혈중농도의 변화
한창수,이민수,김표한,Han, Chang Su,Lee, Min Soo,Kim, Pyo Han 대한생물정신의학회 1996 생물정신의학 Vol.3 No.2
Selective serotonin reuptake inhibitors(SSRIs), as haloperidol, ore metabolized in the cytochrome P450IID6. They can cause inhibition of metabolism of antipsychotics to elevate the serum level of antipsychotics and exacerbate the extrapyramidal symptoms when co-administered with antipsychotics. Among these SSRIs, there ore a few studies about paroxetine compared to fluoxetine or sertraline. In this study, we have intended to know the drug interaction of paroxetine and haloperidol when co-administered two drugs for the chronic schizophrenics by assessing the changes of positive, negative symptoms and extrapyramidal symptoms. for this purpose, we selected 29 subjects, the chronic schizophrenics with no physical problems. They were under maintenance therapy of haloperidol. They ore randomly assigned to placebo group(n=12) and drug group(n=17) by using double blind method. And then, placebo or paroxetine 20mg were administered to the subjects of each groups during 8 week period. We have assessed their psychopathology and extrapyramidal symptoms using Positive and Negative Syndrome Scale(PANSS), Hamilton Rating Scale lor Depression(HRSD), Simpson-Angus Scale at 0, 2, 4, 6, 8 weeks and serum haloperidol, reduced haloperidol levels at 0, 4, 8 weeks during the period. The results ore analysed by using repeated measure MANOVA. 27 subjects have completed the study during 8 weeks. among the subjects, 1) PANSS, HRSD ; no significant difference between groups. 2) Simpson-Angus Scale ; no significant change according to the time and no significant difference between the groups(no group and time effect). 3) Haloperidol and reduced haloperidol level ; no significant change. When co-administered paroxetine and haloperidol, there ore no significant changes of the psychopothology and no significant changes of the extrapyramidal symptoms. In this result, paroxetine seems to be not to affect the metabolism of haloperidol.
한창화,박종석,신준식,이재주,황의규,이경훈 한국습지학회 2014 한국습지학회지 Vol.16 No.1
The research grasps water quality contamination source by investigating the data that are superordinate laws and the relatedplans implemented for establishing water quality improvement measures of upper stream for Chung-Ju Dam, presentconditions of the hydraulic and hydrology, the present conditions and plans of environment basic facilities, and presentconditions of main contamination source’s occurrence load and discharge load, etc. The research used the QUAL2Esimulation which is being widely applied to simulation of river water quality because the QUAL2E has high credibilityamong water quality simulations known throughout the country. On basis of this research, regulations and politic alternativesare required in order to water quality improvement upper stream for the Chung-ju dam, especially establishing processingfacilities in the region where loading amount is concentrated should be considered with the additional research regardingcost-efficient facility of pollution source.
한창대 한국화학공학회 1972 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.10 No.3
A first attempt is presented at investigating the problems of the automatic control of a diammonium phosphate granulation plant. This system is chosen for its simplicity, requiring one solid and one liquid feed stream to the granulator. A dynamic model is developed for the granulator in the form of a set of nonlinear differential equations in the zeroth, first and second moments of the granulator discharge stream particle size distribution. The equations are linearized and it is shown that the responses to similar disturbances of both the nonlinear and linear systems agree closely. Using the linear form, the model is extended to include the entire plant and a feed forward controller is designed by which disturbances in feed rate are used for manipulating the product recycle ratio to maintain constant the average particle size of granulator product.