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Sibutramine의 신규 염인 Sibutramine Mesilate Hemihydrate의 랫드와 비글견에 대한 단회 경구투여 독성
한수철(Su-Cheol Han),차신우(Shin-Woo Cha),서정은(Jeong-Eun Suh),서귀현(Kwee-Hyun Suh) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.4
This study was to investigate single-dose toxicities of sibutramine mesilate hemihydrate (SIBMS), a new salt of sibutramine, in Sprague-Dawley (SD) rats and beagle dogs. The test article was administrated once by gavage to rats at dose levels of 43.1, 86.3, 172.5 and 345.0 ㎎/㎏/day, and to beagle dogs at dose levels of 23.0 and 43.0 ㎎/㎏/day, respectively. For comparison, sibutramine hydrochloride monohydrate (SIBCH) used clinically as anti-obesity agent was administrated to SD rats at dose levels of 37.5, 75.0, 150.0 and 300.0 ㎎/㎏/day and at dose levels of 20.0 and 40.0 ㎎/㎏/day to beagle dogs. In rats, deaths, temporary body weight loss, increased locomotive activity and salivation were observed and the approximate lethal dose of SIBMS was 345.0 ㎎/㎏ for males and 172.5 ㎎/㎏ for females and those of SIBCH was 300.0 ㎎/㎏ for males and 150.0 ㎎/㎏ for females, respectively. In beagle dog, death, temporary body weight loss, vomiting, salivation, hyperemic conjunctiva, anorexia and lacrimation were found. The toxic effect dose of SIBMS were 46.0 ㎎/㎏ and those of SIBCH were 40.0 ㎎/㎏ for both sexes.
실험용 게잡이 원숭이의 pair-housing 효과 2. 혈액학적 지표의 변화
김지은 ( Jee Eun Kim ),한수철 ( Su Cheol Han ),이필수 ( Pill Soo Lee ),허정두 ( Jeong Doo Heo ),김충용 ( Choong Yong Kim ) 한국동물실험대체법학회 2007 동물실험대체법학회지 Vol.1 No.2
The effect of the social enrichment program using mingle cages was investigated in hematological parameters of male cynomolgus monkeys. It is generally believed that the social enrichment program using mingle cages may offer the socialization and the prevention of isolation syndrome such as abnormal behavior. The total of 48 males and 42 females were housed in pairs homosexually with mingle cages reformed from individual cages for 9 weeks and we observed the clinical signs, body weight changes and hematological parameters. In the previous study, Han et al.,2007 observed clinical signs and body weight changes. 93.8 % of male cage mates and 100% of female cage mates were made successful pair-housing formation except 3 cases of male cage mates with serious injuries from fighting. And body weight gains were not changed between individual cage-housing and pair-housing for 9 weeks. However WBC count of male monkeys in individual cage was decreased compared with pair housing group after 8 and 21 weeks from pair housing. Significant increase in neutrophils and decrease in lymphocytes were observed in pair housing group. Thus, this finding indicate that housing condition may change hematological parameters. The present finding may serve as useful basic data for social enrichment program using mingle cage.
연구논문 : 실험용 게잡이 원숭이의 pair-housing 효과 2. 혈액학적 지표의 변화
김지은 ( Jee Eun Kim ),한수철 ( Su Cheol Han ),이필수 ( Pill Soo Lee ),허정두 ( Jeong Doo Heo ),김충용 ( Choong Yong Kim ) 한국동물실험대체법학회 2007 동물실험대체법학회지 Vol.1 No.2
The effect of the social enrichment program using mingle cages was investigated in hematological parameters of male cynomolgus monkeys. It is generally believed that the social enrichment program using mingle cages may offer the socialization and the prevention of isolation syndrome such as abnormal behavior. The total of 48 males and 42 females were housed in pairs homosexually with mingle cages reformed from individual cages for 9 weeks and we observed the clinical signs, body weight changes and hematological parameters. In the previous study, Han et al.,2007 observed clinical signs and body weight changes. 93.8 % of male cage mates and 100% of female cage mates were made successful pair-housing formation except 3 cases of male cage mates with serious injuries from fighting. And body weight gains were not changed between individual cage-housing and pair-housing for 9 weeks. However WBC count of male monkeys in individual cage was decreased compared with pair housing group after 8 and 21 weeks from pair housing. Significant increase in neutrophils and decrease in lymphocytes were observed in pair housing group. Thus, this finding indicate that housing condition may change hematological parameters. The present finding may serve as useful basic data for social enrichment program using mingle cage.
Anti-Inflammatory Effects of Rutin on LPS-Induced Responses in Canine macrophage, DH-82 Cells
Hyunsoo Jang(장현수),Jisu Lee(이지수),Su-Cheol Han(한수철),Ha-Young Shin(신하영),Dahyun Kang(강다현),Su Jeong Kim(김수정),Yeon Woo Kim(김연우),조민서,Jeong Ho Hwang(황정호),Jung-Heun Ha(하정헌) 한국지역사회생활과학회 2024 한국지역사회생활과학회 학술대회 자료집 Vol.2024 No.6
Cynomolgus Monkey에 있어 혈액학 및 혈액생화학적 지표
김충용(Choong-Yong Kim),이현숙(Hyun-Sook Lee),한수철(Su-Cheol Han),허정두(Jeong-Doo Heo),하창수(Chang-Su Ha),권명상(Myung-Sang Kwon),정문구(Moon-Koo Chung) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.1
To provide basic information on blood for safety assessment, physiological levels of hematology and serum chemistry were ascertained in nineteen male (average body weight, 2.86 ㎏) and sixteen female (average body weight, 2.73 ㎏) cynomolgus monkeys. Hematologic parameters included fourteen items including red blood cells (RBC) hemoglobin (Hb), hematocrit (HCT), white blood cells (WBC) and differential leukocyte counts (%WBC). Serum biochemical parameters included twenty items including alkaline phosphatase (ALP), creatinine (CREA), creatine phosphokinase (CPK), triglyceride (TG), inorganic phosphorous (IP), etc. Hematological levels showed great variation in platelet, reticulocyte and WBC, whereas showed less variation in RBC, Hb, and HCT. Serum biochemical levels showed great variation in aspartate aminotransferase (AST), alanine aminotransferase (ALT), ALP, Blood urea nitrogen (BUN), glucose (GLU), total cholesterol (TCHO), CPK, TG, total bilirubin (TBIL), phospholipid (PL) and inorganic phosphate (IP), whereas showed less variation in albumin/globulin ratio (A/G ratio), total protein (TP), albumin (ALB), sodium (Na), potassium (K), chloride (Cl). Hematological determined showed greater values of Hb, and HCT in males than in females, while serum biochemical assay showed greater values of ALP, CPK and IP in males than in females. The present study will be valuable in the proper interpretation and validation of general toxicology studies using cynomolgus monkeys.