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      • 비소세포 폐암에서 COX-2, MMP-9, p53 및 VEGF 발현에 대한 면역조직화학적 연구 : 편평세포암종과 선암종을 대상으로

        하경원 중앙대학교 의과대학 의학연구소 2007 中央醫大誌 Vol.32 No.3

        Purpose: This study was performed to investigate immunohistochemical expression of COX-2, MMP-9 and p53 using surgical specimens of 97 non-small-cell lung cancer cases and to evaluate the relationship between the expression of each molecule and clinicopathologic factors or prognosis. Methods: The following formalin-fixed paraffin embedded surgical specimens were immunohistochemically stained by avidin-biotin complex method for COX-2, MMP-9 and p53; 60 cases of primary squamous cell carcinoma and 37 cases of primary adenocarcinoma of the lung. Results: COX-2 expression of adenocarcinoma is statistically higher than that of squamous cell carcinoma (p<0.01). However, MMP-9, p53 and VEGF expression is not significantly associated with the histologic type of cancer. COX-2 expression was significantly associated with the clinical staging (p<0.05), whereas MMP-9, p53 and VEGF expression were not. Synchronous expression of each molecules (COX-2 + MMP-9 + p53 + VEGF, COX-2 + MMP-9 +p53, COX-2 + MMP-9 + VEGF, COX-2 + p53 + VEGF, COX-2 + MMP-9, COX-2 + p53, MMP-9 + p53, COX-2 + VEGF, MMP-9 + VEGF, p53 + VEGF) was 62.4% in frequency and revealed increased tendency in advanced cancer than early cancer. VEGF expression showed to portend a short survival among patients with non-small cell lung cancer (p=0.05). Conclusion: These results suggested that COX-2 overexpression might be an indicator of an unfavorable clinical outcome and VEGF overexpression appears to portend a short survival. However, further studies of a possibility of prognostic significance, such as MMP-9, p53 and synchronous production of gene products, are required for the determination of significant relationship in other clinicopathologic indices.

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