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Clostridium acetobutylicum의 대사망의 동적모델 개발
박선원 ( Sun Won Park ),김우현 ( Woo Hyun Kim ),엄문호 ( Moon Ho Eom ),이상현 ( Sang Hyun Lee ),최진달래 ( Jin Dal Rae Choi ) 한국화학공학회 2013 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.51 No.2
To produce biobutanol, fermentation processes using clostridia that mainly produce acetone, butanol and ethanol are used. In this work, a dynamic model describing the metabolic reactions in an acetone-butanol-ethanol (ABE)-producing clostridium, Clostridium acetobutylicum ATCC824, was proposed. To estimate the 58 kinetic parameters of the metabolic network model with experimental data obtained from a batch fermentor, we used an efficient optimization method combining a genetic algorithm and the Levenberg-Marquardt method because of the complexity of the metabolism of the clostridium. For the verification of the determined parameters, the developed metabolic model was evaluated by experiments where genetically modified clostridium was used and the initial concentration of glucose was changed. Consequently, we found that the developed kinetic model for the metabolic network was considered to describe the dynamic metabolic state of the clostridium sufficiently. Thus, this dynamic model for the metabolic reactions will contribute to designing the clostridium as well as the fermentor for higher productivity.