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Other up-to-date treatment modalities of vitiligo
최종원 ( Chong Won Choi ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Vitiligo is an acquired depigmenting disorder that occurs in about 1% of the population. The white macules and patches in vitiligo patients are the consequence of melanocyte destruction in the skin and they can be an emotional stress on the vitiligo patients. The immune modulating agents (systemic/topical steroids, topical calcineurin inhibitors) and phototherapy (narrow band UVB and excimer laser) are the mainstay of current modalities for the treatment of vitiligo. Despite the increased knowledge of pathogenesis and the enthusiastic use of above-mentioned treatment modalities, current management for vitiligo cannot ensure the complete cure. To overcome the limitation, diverse attempts have been tried and various results have been reported. Herein, I will talk about the up-to-date treatment modalities of vitiligo through a review of recently published papers. The talk will include the use of cytokines and its analogue (α-MSH analogue, afamelanotide), inhibitors for cell signaling pathways (Janus kinase inhibitor, tofacitinib), antibiotics (tetracycline and its derivative, minocycline), and lasers (CO<sup>2</sup> fractional laser) in the treatment of vitiligo. Recent clinical trials and the possible mechanism of each modality will be briefly reviewed.
인삼 성분이 Ethanol의 장관내 흡수에 미치는 영향
허근,최종원,Huh, Keun,Choi, Chong-Won 대한약학회 1983 약학회지 Vol.27 No.2
The effect of ginseng butanol fraction (total sponin) on the absorption rate of ethanol in rat intestine was examined. Ginseng butanol fraction showed inhibitory effect on the intestinal absorption of ethanol in situ as well as in vitro test. Ginseng butanol fraction markedly decreased the ethanol blood level, delayed onset time of ethanol effect and shortened sleeping time when it was adminstered orally together with ethanol. These results suggest that ginseng may alter the ethanol blood level by decreasing the intestinal absorption of ethanol.
허근,최종원,Huh, Keun,Choi, Chong-Won 대한약학회 1984 약학회지 Vol.28 No.1
After pretreatment with ginseng followed by induction of acute intoxication of alcohol, the activities of alcohol dehydrogenase (ADH), microsomal ethanol-oxidizing system (MEOS) and aldehyde dehydrogenase(Ald DH) increased respectively compared to the groups treated with alcohol alone. In case that ginseng was given to rats fed with 5% alcohol instead of water for 60 days, the activities of ADH and MEOS increased compared to the groups treated. On the contrary, the activity of Ald DH in mitochondrial fraction decreased to an extent of about 35% in chronic alcoholism, but after pretreatment of ginseng the activity was restored to the control level. On the other hand, the catalase activity was not significantly affected by either treatment. Ginseng butanol fraction significantly increased the serum isocitrate dehydrogenase activity which is inhibited by alcohol-treated in rat. Alcohol-induced lactate dehydrogenase activity was decreased to control level in liver by ginseng treatment. And the serum level of lactic acid also decreased by ginseng treatment in alcohol-intoxicated rat. Ginseng butanol fraction markedly decreased the xanthine oxidase activity in the ethanol-treated rat liver. It was also observed that ginseng reduced the blood concentration of uric acid on experimentally reduced hyperuricemia by alcohol treatment. Uricase activity was not affected by either treatment. Ginseng butanol fraction decreased the hepatic aniline hydroxylase activity which was induced by alcohol-treated rat. These results suggest that the treatment with ginseng can be promoted the recovery from alcohol intoxication and some therapeutic effect on alcoholinduced metabolic disease.