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STZ 유발 당뇨쥐에서 시간에 따른 생리적 항산화계의 변화
이순재,양정아,김성옥,최정화,신주영,채영미,차복경 대구효성가톨릭대학교 응용과학연구소 1997 응용과학연구논문집 Vol.5 No.-
The purpose of this study was to investigate change of physiological antioxidative system according to the time in streptozotocin-induced diabetic rats. Sprague-Dawley male rats weighing 150±10gm were randomly assigned to one normal and five STZ-induced diabetic groups. Diabetic groups were classified to experimental period. Diabetes was experimentally induced by intravenous injection of 55 mg/kg of body weight of STZ in citrate buffer(PH 4.3) after 6 weeks feeding of three experimental diets. Animals were sacrificed at 0, 3, 6, 12, 18th days of diabetic states. 1. Activity of superoxide dismutase(SOD) in liver was increased in that of diabetic mellitus(DM) groups at 3th day but that of DM groups was not significant from 6th day according to period. Glutathion peroxidase(GPX) was significantly decreased in DM groups from 6th day 2. Reduced glutathione(GSH) contents in liver significantly decreased in diabetic groups from 3rd day compared with those of DM groups according to the period. Oxidized glutathione(GSSG) was higher from 6th day. GSH/GSSG ratio was significantly lower than that of normal group from 3rd day to all experimental period 3. Contents of vitamin E in liver of DM groups were significantly decreased compared with that of normal group from 6th day. 4. Lipid peroxide(LPO) contents in liver of DM groups were significantly increased compared with that of normal group from 3rd day. The present results indicate that STZ-induced diabetic rats were reduced by antioxidative defense system and taken by peroxidate damage in tissue compared with normal group from 3rd day or 6rd day after injection STZ. It lended to acceleration all diabetic groups but no significance according to the experimental time.
비만 및 체중증가를 주소로 내원한 갑상선 기능저하증 환자 3예의 임상적 고찰
박혜순,최정화 대한비만학회 1994 The Korean journal of obesity Vol.3 No.1
Obesity is ane of the commcm problems in outpatient clinic. The most common cause of weight gain is simple obesity, which resulted from excessive calori intake an$lt;I lack of calori consumption. Secondary obesity is rare. We reviewed 3 cases of hqwthyroidism presented with obesity or weight gain. Among the patients with obesity or weight gain, 3 patients with hypothyroidism were found. We reviewed the initial and posttreatment features of clinical and laboratory findings. Case 1) A 19-year-old male came with weight gain. Body weight 85.5Kg, BMI 28.2Kg/m, obesity mdex 137%, hemoglobin 11.9g/dl, hematocrit 35.3%, cholesterol 279mg/dl, AST/ALT 319/ 108IU/L, FreeT O.lng/dl, and TSH 108ulU/ml. At 3 months after thyroid hormone replacement therapy, his body weight was decreased to 75Kg, BMI 24.8Kg/m, and hypercholesterolemia, anemia, abnormal liver function and thyroid hormone level were noimalized. Case 2) A 12-year-old girl came wnh puffiness, weight gain, constipation. Body weight 51.2Kg, BMl 22.3Kg/m, obesity index 114%, choiesterol 324mg/dl, AST/ALT 97/981U/L, Ti $lt;50ng/ml, T $lt;2.5ug/dl, and TSH 20lulU/ml. At 3 months after harmone replacement therapy, her bodyweight was decreased to 45Kg, BM1 19.6Kg/m and all abnormai findings were normalized. Case 3) A 27-year-o1d woman came with weight gain and edema. Rody weight 56Kg, BMI 22.1 Kg/m, obesity index 109%, hemoglobin 8.9g/dl, cholesterol 3l9mg/dl, AST/ALT 147/95IU/L, Free T$lt;0.1ng/dl, and TSH 76,0uIU/ml. At 3 months after hormone replacement therapy, her body weight was decreased to 54Kg, BMI 21.6Kg/m and anemia, hypercholesterolemia, abnormal liver function were improved. The most common cause of the obesity and weight gain is simple obesity. But we must consider secondary cause of them. They are not responsive to canservative weight control therapy, but they are controlled with correction of the underlying disease.