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간세포암종에서 Cyclin D1과 pRb 발현에 대한 면역조직화학적 연구
최재호 외 중앙대학교 의과대학 의학연구소 2004 中央醫大誌 Vol.29 No.3·4
An alteration in the cell cycle-related genes is one of the most common events seen in human carcinogenesis. Although aberration of cyclin D1 and pRb have been reported to be involved in hepatocellular carcinoma, the stages of the multistep process of hepatocarcinogenesis affected by them remain unknown. So, to determine the role of cyclin D1 and pRb in hepatocarcinogenesis, I examined cyclin D1 and pRb expression immunohistochemically in hepatocellular carcinoma and non-cancerous tissue with cirrhosis and chronic hepatitis. The patient consisted of biopsied or surgically resected 40 cases of hepatocellular carcinoma with 12 cases of grade II and 28 cases of grade III, 10 cases of cirrhosis with or without hepatocellular carcinoma and 10 cases of chronic hepatitis. The results were as follows; 1. Cyclin D1 expression was observed in 25 of the 40 hepatocellular carcinoma (62.5%) and 3 of the 10 cirrhosis (30%). 2. Cyclin D1 expression of hepatocellular carcinoma was significantly associated with tumor differentiated grade (p=0.022) and T-stage (p=0.047); altered cyclin D1 expression occured in 6 of 12 (50%) and 19 of 28 (67.9%) grade II and grade III hepatocellular carcinoma; in 4/7 (57.1%), 6/9 (66.7%) and 8/11 (72.7%) stage II, stage III and stage IV. 3. pRb expression was observed in 3 of the 40 hepatocellular carcinoma (7.5%), and no expression was noted in cirrhosis and chronic hepatitis. Therefore, the results suggest that the cyclin D1 expression is closely associated with tumor progression and developing metastasis rather than that of pRb expression in cases of hepatocellular carcinoma.
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