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오타모반의 임상 및 병리조직학적 검색 -대한피부과학회 피부병리 연구분과위원회 공동연구-
천승현 ( Seung Hyun Chun ),이상훈 ( Sanghoon Lee ),박하나 ( Hana Park ),전수영 ( Su Young Jhun ),손인범 ( In-Bum Sohn ),김학용 ( Hak Yong Kim ),최응호 ( Eung Ho Choi ),황상민 ( Sang Min Hwang ),이승헌 ( Seung Hun Lee ),김중기 ( Jo 대한피부과학회 2004 대한피부과학회지 Vol.42 No.3
Background: Ota`s nevus, characterized by the presence of melanocytes in the dermis, has been familiar among dermatologists, but the etiology, the pathophysiology, the clinical and histological classification are not entirely clear. To understand and elucidate them, more clinical studies and researches are necessary. Object: The aim of this study was to document the clinical and histopathological features of Ota`s nevus. Methods: We examined 299 patients with Ota`s nevus who visited the dermatology clinic in Korea from February 1993 to August 2003. Among them, 188 patients were biopsied. All the specimens were stained with hematoxylin and eosin. We examined the age & sex distribution, age of onset, seasonal variation, associated skin diseases, aggravating factors and color. We clinically classified Ota`s nevus into 4 types according to Tanino`s classification and histologically into 5 types based on the pattern of pigmentation. Results: 1. The ratio of male and female was 1:3. 2. The peak age of onset was at birth (28.4%) and puberty (24.8%). 3. Seasonal variation was observed with distinct aggravation in the summer (60%). 4. The associated diseases were 9 cases of persistent mongolian spot, 6 cases of nevus flameus, 4 cases of blue nevus, 3 cases of vitiligo, 3 cases of mevus of Ito, 2 cases of atopic dermatitis, 2 cases of psoriasis, 2 cases of cafe au late macules and 2 cases of contact dermatitis. 5. The aggravating factors were sunlight (35.8%), emotional stress (21.0%), menstruation (12.6%), cold exposure (9.5%), pregnancy (9.5%), fatigue (9.5%) and chemical agents (2.1%). 6. The color of lesions were blue black (36.8%), brown (34.8%), dark brown (16.1%) and slate (11.0%). 7. All cases were classified according to Tanino`s methods: type Ia (23.1%), type Ⅰb (20.1%), type Ⅱ (26.7%), type Ⅲ (9.4%), type Ⅳ (20.7%). 8. The histological subtypes of Ota`s nevus were classified as: the superficial type (35.6%); the middermis type (5.9%), the superficial-middermis type (18.6%); the mid-lower dermis type (2.7%); the diffuse type was composed of the superficial dominant type (19.7%), the middermis dominant type (4.8%), the dispersed (true diffuse) type (12.2%) and the deep dominant type (0.5%). 9. In the relation between histological types and the color of the lesion: the superficial type had 31 cases of brown color, 15 cases of blue black color, 11 cases of dark brown color and 9 cases of slate color; the middermis type had 6 cases of blue black color and 2 cases of dark brown color, query number of cases of slate color; the superficial-middermis type had 12 cases of blue black color, 10 cases of dark brown color, 7 cases of brown color and 6 cases of slate color: the mid-lower dermis type had 3 cases of blue black color; for the diffuse type, the superficial dominant type had 13 cases of brown color, query number of cases of blue black color and 7 cases of dark brown color; the mid-dermis dominant type had 4 cases of brown color, query number of cases of dark brown color, the dispersed type had 14 cases of blue black color and 5 cases of brown color, the deep dominant type had 1 case of blue black color. Conclusion: The histological reclassification of Ota`s nevus may be very useful in making a therapeutic prognosis of the disease. (Korean J Dermatol 2004;42(3):272~280)
천승현 ( Seung Hyun Chun ),최응호 ( Eung Ho Choi ),황상민 ( Sang Min Hwang ),이승헌 ( Seung Hun Lee ),안성구 ( Sung Ku Ahn ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.5
N/A Background : Inverted follicular keratosis has distinctive histopathological features and is infre-quently encountered by dermatologists. To date, the pathogenesis of inverted follicular keratosis has not been elucidated. Many authors have suggested several theories for the nature of inverted follicular keratosis including verruca vulgaris with squamous eddies, irritated seborrheic keratosis and distinctive follicular tumors. There are no comprehensive studies about the clinical and histopathological features of inverted follicular keratosis in Korea. Objective : The purpose of this study was to analyze the clinical features and histopathological findings of inverted follicular keratosis with literature review. Methods : We studied 14 patients with inverted follicular keratosis for clinical features including the duration of the disease, the location and size of the lesions, the clinical impressions at the first visit and we made a record of the patients` age and sex, histopathological findings. Results : 1. Eight of the 14 patients were male and the ages ranged from 40 to 83 years (mean 59.3 years). The lesions were situated on the face (5/14), scalp (3/14), abdomen (2/14), hand (2/14), buttocks(1/14), shin (1/14). The average size of the lesions was 1.38㎝ 2. Seborrheic keratosis was the most common clinical diagnosis (6/14), followed by verruca vulgaris(4/14), cutaneous horn (1/14), melanoma (1/14), soft fibroma (1/14) and pigmented nevus (1/14). 3. Solid and nodular types were the most common histopathological type (7/14). followed by keratoacanthoma-like type (5/14), filiform or wart like type (2/14). Conclusion : Inverted follicular keratosis have unusual clinical and histopathological features. We recommend that verrucous plaque lesions should be diagnosed correctly by histopathologic examination and it may be helpful to avoid inappropriate therapeutic approach. (Korean J Dermatol 2003;41(5) : 597~601)
콜히친으로 치료한 성인에서의 재발성 특발성 호중구성 한선염 1예
박지현 ( Ji Hyun Park ),천승현 ( Seung Hyun Chun ),김보영 ( Bo Young Kim ),유화정 ( Hwa Jung Ryu ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.5
Idiopathic neutrophilic eccrine hidradenitis is usually observed in healthy children with tender erythematous nodules on the soles or palms. We report a case of a 26-year-old man with a painful erythematous swollen patch on both hands and feet. His symptom recurred once monthly over 2 years; thus, he visited Orthopedics. However, no bony abnormality was identified. We performed a skin biopsy on an erythematous indurated patch on his right sole. Histopathological findings indicated neutrophilic eccrine hidradenitis. After 2 weeks of treatment with oral colchicine, his symptom resolved, and no relapses were observed during follow-up. Only a few case reports describe idiopathic neutrophilic eccrine hidradenitis in adults, which is not associated with malignant hematological disease, solid cancer, and chemotherapy. Conventional treatment comprises bed-rest and the administration of topical steroids. Colchicine can be a good treatment option for adults with severe or recurrent idiopathic neutrophilic eccrine hidradenitis. (Korean J Dermatol 2018;56(5):322∼324)
무모생쥐에서 아세톤 자극후 스테로이드의 국소도포 및 스테로이드 주사에 의한 피부장벽의 회복효과
안성구(Sung Ku Ahn),천승현(Seung Hyun Chun),최응호(Eung Ho Choi),이승헌(Seung Hun Lee) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.10
N/A Background : Acetone disrupts the cutaneous permeability barrier thtough the removal of stratum corneum lipids. This pertubation of barrier integrtity stimulates a variety of homeostatic repair that ultimately results n the normalization of barrier function. Object : To measure the effect of steroid on the barrier recovery of acetone applied skin, Material and Methods : The flank skin of 8∼10week old hairless mice was treated with acetone and then topical and systemic steroids were applied. Transepidermal water loss(TEWL) was checked after 0, 3, 6, 12 and 24 hours. Electron and light microrcopic examination and ion capture cytochemistry were performed after 3, 6, 12 and 24 hours ter systemic and topical steroids had been applied. Results The results were as follows ; 1) During 3∼6 hours after experiment, the recovery rate of TEWL was most prominent in the group of acetone applied animal than other group. 2) After 12 hours after acetone applied, formation of new stratum corneum was found in the groups of acetone applied or acetone applied skin with topical steroid application. But loss of stratum corneum was observed in the groups of high or low dose steroid injection. 3) Ruthenium tetroxide staining of acetone alone or topical steroid treated specimens after 12 hours experiment revealed that the lipid bilayer was partly impaired and fragmented, Intercellular spaces were widening and the lipid bilayer disappeared or was damaged in the groups of high or low dose steroid injection. 4) Six hours after acetone application, pattern of calcium distribution had been partially reestabilished in the group of acetone alone or topical steroid treated animals. But calcium content was still sparse and decreased from the stratum granulosum to basale in the groups of high or low does steroid injection.
기존 치료에 반응이 없는 백반증에서 비박피성 1,550 nmEr:Glass Fractional Laser 및 NB-UVB, 국소도포제 병합치료요법이 효과를 보였던 1예
박재범 ( Jae Beom Park ),박지현 ( Ji Hyun Park ),천승현 ( Seung Hyun Chun ),장희원 ( Hee Won Jang ),유화정 ( Hwa Jung Ryu ),김일환 ( Il-hwan Kim ) 대한피부과학회 2016 大韓皮膚科學會誌 Vol.54 No.4
TThere are many therapeutic methods for treating vitiligo, including narrow-band UVB, topical corticosteroids, calcineurin inhibitors, excimer laser, and surgical methods, such as autologous epidermal grafting and dermabrasion. However, although various treatments have been tried, there is still no reliable treatment. Recently, there were several reports about the use of fractional laser combined with narrow-band (NB) UVB to treat vitiligo. A 33-year-old male patient presented with hypopigmented patch on lower right abdominal area. After being diagnosed with vitiligo, the patient underwent NB-UVB treatment and application of a topical agent for two years but failed to show response. To evaluate the efficacy of non-ablative fractional laser, a 1550-nm erbium:glass (Er:Glass) fractional laser was applied to whole area of the lesion. The area showed erythema and brown microscopic epidermal necrotic debris. Five days after the laser procedure, NB-UVB treatment with application of a topical agent was initiated once or twice a week, followed by pigmentation of the treated area . The fractional laser was reapplied three months later, and the patient is currently under observation and is still being treated with NB-UVB. We observed successful treatment of refractory vitiligo with the combination of non-ablative 1550-nm Er:Glass fractional laser, NB-UVB, and a topical agent. We consider non-ablative Er:Glass fractional laser as a favorable choice of treatment for refractory vitiligo. (Korean J Dermatol 2016;54(4):280~283)
접촉 피부염 환자에서 모메타손 크림의 피부 장벽 기능에 미치는 영향에 대한 평가
소병준 ( Byoung Joon So ),박재범 ( Jae Beom Park ),천승현 ( Seung Hyun Chun ),손상욱 ( Sang Wook Son ) 대한피부과학회 2015 대한피부과학회지 Vol.53 No.5
Background: It is unclear how the usage of topical steroid agents affects skin barrier function. Objective: In order to follow up on previous research into this topic, we sought to investigate the effects of a 3-week application of topical mometasone cream on the alteration of skin barrier function. Methods: Twenty-six patients who had been clinically diagnosed with allergic contact dermatitis were enrolled. Topical mometasone cream was applied to the skin lesions. Clinical symptoms, transepidermal water loss (TEWL), corneometer unit, and pH value were measured on the initial visit, 1 week after treatment, and 3 weeks after treatment, and their values were compared. Results: Clinical symptoms showed improvement after topical mometasone cream was applied (p<0.05), but changes in TEWL, corneometer units, and pH values failed to show statistical significance (p>0.05). Conclusion: This study found that treatment with topical mometasone cream for 3 weeks has no effect on skin barrier function. We believe that this research will help determine the optimal duration and dosage of topical steroid agents used for treating allergic contact dermatitis. (Korean J Dermatol 2015;53(5):347∼350)