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차봉연,Cha, Bong-Yeon 사단법인 한국당뇨협회 2005 당뇨 Vol.184 No.-
당뇨병성 신증은 초기에 진단하여 이를 치료하는 것이 중요하다. 일단 알부민뇨가 300mg/day 이상이면 일반뇨 검사시 단백뇨로 검출되는데, 이러한 환자는 결국 말기 신부전증으로 진행되기 때문이다.
이승환 ( Seung Hwan Lee ),차봉연 ( Bong Yun Cha ) 대한내과학회 2009 대한내과학회지 Vol.77 No.4
A 32-year-old woman presented with general weakness and low abdominal discomfort for 7 days. She had been diagnosed with type 1 diabetes at the age of 16 and was being treated with continuous subcutaneous insulin injections. Acute pyelonephritis had occurred three times previously and vesicoureteral reflux had been documented. On admission, hematuria, pyuria, and bacteriuria were noted with a leukocyte count of 10,410 mm-3 and elevated C-reactive protein level (16.8 mg/dL). A kidney/ureter/bladder (KUB) X-ray and pelvic computed tomography (Fig. 1) showed an air density delineating the bladder wall, which was diagnostic of emphysematous cystitis. Klebsiella pneumoniae was cultured in the urine specimen. The patient recovered fully after a 2-week treatment with cefuroxime (Fig. 2). Emphysematous cystitis is a potentially life-threatening infection that usually develops in patients with diabetes mellitus, neurogenic bladder, recurrent urinary tract infection, or urinary tract outlet obstruction. As this disease has variable clinical features and course, it should be suspected in diabetics with urinary tract infection and worsening renal function. Although surgical management is sometimes required, antibiotics, bladder drainage, and glycemic control are the mainstay of treatment.
소의 대동맥 내피세포에서 산화저밀도 지단백에 의한 아포프토시스에 백일해 독소 및 콜레라 독소가 미치는 영향
손호영(Ho Young Son),강성구(Sung Ku Kang),강무일(Moo Il Kang),차봉연(Bong Youn Cha),이광우(Kwang Woo Lee),장상아(Sang Ah Chang),최윤희(Yoon Hee Choi),문성대(Sung Dae Moon),안유배(Yoo Bae Ahn),손현식(Hyun Sik Son),윤건호(Kun Ho Yoon) 대한내과학회 1999 대한내과학회지 Vol.56 No.5
Objectives : Oxidized LDL is thought to play a key role in atherogenesis. Among their wide variety of biological properties, oxidized LDL injures the endothelium as an early event of atherogenesis. However, the mechanisms by which oxidized LDL injures endothelial cells are not definitely known. In order to evaluate the involvement of GTP-binding protein on the mechanism of apoptosis, we studied the effects of pertussis and cholera toxin on oxidized LDL-induced apoptosis in bovine aortic endothelial cells(BAECs). Methods : Oxidized LDL elicited apoptosis in cultured BAECs as shown by characteristic morphological and biochemical changes. Chromatin condensation and nucleus fragmentation were visualized by using fluorescence microscopy of intact cells staining by acridine orange/ ethidium bromide. DNA fragmentation was quantified by an ELISA with specific antibody for bromodeoxyuridine- labelled DNA fragments and confirmed with DNA ladder formation. Results : Studies using a combination of bacterial toxins which change the function of GTP-binding protein suggest that oxidized LDL-induced apoptosis was regulated by GTP-binding protein. Oxidized LDL-induced apoptosis was not changed by pretreatment of BAECs with pertussis toxin. In contrast, pretreatment with cholera toxin completely prevented the oxidized LDL- induced apoptosis. Conclusion : These results show that oxidized LDL induces apoptosis of BAECs and suggest that cholera toxin-sensitive G-proteins are involved in signal transduction of oxidized LDL-induced apoptosis of BAEC.
TSH 분비성 뇌하수체 선종 환자에서 SMS 201 - 995 의 효과
이종민(Jong Min Lee),홍관수(Kwan Su Hong),차봉연(Bong Yun Cha),이광우(Kwang Woo Lee),손호영(Ho Young Son),강성구(Sung Soo Kang),방병기(Byong Kee Bang) 대한내과학회 1987 대한내과학회지 Vol.33 No.6
N/A Excessive TSH secreting pituitary tumor is one of the rare causes of the hyperthyroidism. Its clinical characteristics are distinguished from hyperthyroidism caused by Graves' disease, toxic nodular goiter, subacute or Hashimoto's thyroiditis which shows suppressed serum TSH level. TSH-secreting pituitary adenoma are often invasive and refractory to usual treatment. SMS 201-995, a long acting somatostation analogue has been effective in the management of GH-secreting pituitary adenomas. Since somatostatin inhibits TSH secretion by normal pituitary thyrotrophs, we evaluated its effect in a TSH-secreting pituitary adenoma. A 35year old female with hyperthyroidism has been treated with antithyroid drugs under the diagnosis of Graves disease since 1980 and correctly diagnosed as TSH-sereting pituitary adenoma on May, 1986. Thyroid homone levels were elevated (T3: 190-310 ng/dl, T4. 10 -21 ug/dl) and serum TSH was inappropriately elevated (TSH: 2.1-31 μIU/ml) before SMS 201-995 treatment. SMS 201-995 (50 ㎍s.c. bid for 2 days and then 100 ㎍s.c. bid for 3 days) resulted in a dramatic reduction of TSH, T3, T4 level (T3: 150 ng/dl, T4: 11.8 ug/dl, TSH: l.9 μIU/ml). 4 days after SMS201-995 discontinuation, T3 T4, TSH elevated again (T3: 390ng/dl, T4: 16.5ng/dl, TSH: 19.0 μIU/ml). SMS 201-995 (100 ug s.c. bid for 7 days) was resumed with the same benefit (T3: 190 ng/dl T4: 9.8 ug/dl, TSH: 7.0 μIU/ml). After short-term therapy with SMS 201-995, goiter was markedly diminished. Severe adverse effect was not observed during therapy except slightly increased frequency of defecation. This report sugget that SMS 201-995 may be an alternative means of controlling hypersecretion of TSH and the associated hyperthyroidism due to TSH- secreting pituitary tumor.
만성신부전증 환자에서 혈액투석, 복막투석 및 신장이식이 혈중 Apolipoprotein(a) 농도에 미치는 영향
윤건호 ( Kun Ho Yoon ),유순집 ( Soon Jip Yoo ),강무일 ( Moo Il Kang ),차봉연 ( Bong Yun Cha ),윤영석 ( Young Suk Yoon ),이광우 ( Kwang Woo Lee ),손호영 ( Ho Young Son ),강성구 ( Sung Koo Kang ),방병기 ( Byung Kee Bang ) 한국지질동맥경화학회(구 한국지질학회) 1996 韓國脂質學會誌 Vol.6 No.1
유순집(Soon Jib Yoo),안중현(Jung Hyune Ahn),윤건호(Kun Ho Yoon),차봉연(Bong Yun Cha),최의진(Euy Jin Choi),이광우(Kwang Woo Lee),손호영(Ho Young Son),강성구(Sung Koo Kang),김욱(Wook Kim),장은덕(Eun Deok Chang),이해규(Hae Giu Lee) 대한내과학회 1994 대한내과학회지 Vol.46 No.6
Hypercalcemia associated with chronic renal failure is often a matter of clinical problems. Among the many cause of hypercalcemia, tertiary hyperparathyroidism, which is secreting parathyroid hormone autonomously in spite of hypercalcemia, is seldom reported. Sometimes it requires surgical intervention due to not only symptomatic hypercalcemia, but also longlasting asymptomatic hypercalcemia. We recently have experienced a female patient with hypercalcemia in a thirty- seven-year old, who maintains on hemodialysis. She had received kidney from her husband due to chronic renal failure, but it had rejected acutly. She had markedly elevated level of C-terminal parathyroid hormone and radiologic manifestation of adernoma of the parathyroid gland. The bone pathology was consistent with ostitis fibrosa. Subtotal parathyroidectomy showed 1 adenoma and 2 hyperplasia pathologically, afterthen improved clinically and biochemically.
Bromocriptine 치료후 소실된 유즙분비성 뇌하수체 거대선종
이호선(Ho Sun Lee),이광우(Kwang Woo Lee),차봉연(Bong Yun Cha),손호영(Ho Young Son),강성구(Sung Koo Kang),방병기(Byung Kee Bang) 대한내과학회 1986 대한내과학회지 Vol.30 No.6
N/A Hyperprolactinemia is the most common form of pituitary hyperfunction. It is presented in many infertile women. Since the development of specific assay for prolactin and CT examination of the pituitary gland, it has been possible to demonstrate that a large proportion of pituitary tumors secrete prolactin. Until the advent of bromocriptine, operation and irradiation had been used as the primary treatments for such tumors. But recently the introduction of bromocriptine, an ergot derivative and dopamine agonist, into therapeutic regimen for pituitary tumor is being evaluated. Medical therapy of prolactinoma with bromocriptine has been demonstrated to reduce serum prolactin level to normal and also to reduce the size of such tumor. A 23-year-old single female patient with macro-prolactinoma was treated with bromocriptine. Five months after the administration of bromocriptine, galactorrhea disappeared with appearance of normal menstural cycle and normal serum prolactin level. And 12 months after bromocriptine treatment, the follow up CT scan of pituitary gland revealed regression of tumor mass. During the medical treatment no remarkable complication or intolerance was developed. It is suggested that bromocriptine treatment could be considered as a single agent treatment in macroprolactinoma, even in case with extra sellar extension.
임상화보 : 면역 억제제를 투여하지 않은 당뇨병 환자의 거대세포바이러스 대장염
성필수 ( Pil Soo Sung ),장진선 ( Jin Sun Jang ),차봉연 ( Bong Yun Cha ) 대한내과학회 2010 대한내과학회지 Vol.79 No.5
66세 여자가 1주일 전부터 혈성 설사가 있어 내원하였다. 과거력에서 환자는 35년간 제2형 당뇨로 추적관찰 중이었으며 당시 HbA1c가 8.0%로 혈당 조절 정도가 불량한 상태였다. 내원 당시 말초혈액검사에서 백혈구 수치는 17,130/mm3 (segmented neutrophil 85.3%), 혈색소 11.3 g/dL였으며, 혈청 생화학 검사상 특이소견은 없었다. Anti-HIV ELISA는 음성이었으며 혈액 및 대변배양검사도 음성이었고, 대변 Clostridium difficile toxin 검사도 음성이었다. 대장내시경검사에서 맹장에서 하행 결장에 이르는 구역에서 경계가 분명한 다수의 깊은 궤양이 관찰되어 생검을 시행하였다(그림 1). 조직검사에서 염증세포 사이에 봉입체를 함유한 거대세포가 관찰되어 거대세포바이러스 면역항체로 특수 염색을 하였고, 그 결과 거대세포바이러스 장염으로 확진하였다. 이에 일일 valgancyclovir 900 mg을 3주간 경구로 투여하였고, 투여 종료 후 시행한 대장내시경검사에서 이전에 관찰되었던 궤양은 소실되었고, 조직검사에서 거대세포는 더 이상 관찰되지 않았다(그림 2). Cytomegalovirus (CMV) 대장염은 후천성 면역 결핍증이나 장기 이식을 받은 환자, 면역 억제 치료를 받고 있는 환자에서 잘 알려진 설사와 위장관 출혈의 원인이나 면역 기능이 정상인 환자에서는 매우 드물게 발생하는 것으로 알려져 있다1). Henson2)에 따르면 면역억제의 기왕력이 없는 경우에 발생한 CMV 대장염 환자의 2/3가 당뇨 환자였다. 따라서 혈성 설사로 내원한 당뇨 환자가 대장내시경 소견에서 궤양 병변을 보일 때는 거대세포바이러스 감염의 가능성을 생각하여 확진을 위해 조직검사와 특수 염색이 필요하다. 면역력이 정상인 경우에 발생하는 CMV 대장염은 예후가 좋아서 대부분 대증 치료만으로 호전된다3). 하지만 당뇨 환자의 경우 고혈당과 연관된 면역 저하의 여러 기전이 제시되고 있으며, 실제로 이로 인하여 세균 및 바이러스, 진균 감염이 일어날 가능성이 높다4). 따라서 고령의 당뇨 환자에서 CMV 감염에 의한 위장관 침범이 있는 경우에는 이번 증례와 같이 항바이러스제를 사용하는 것이 필요하다.