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The Use of Lens Shielding Device(L.S.D.) for a Conjunctival Lymphoma
조현상,주상규,송기원,박영환,Cho Hyun Sang,Ju Sang Gyu,Song Ki Won,Park Young Hwan 대한방사선치료학회 1997 大韓放射線治療技術學會誌 Vol.9 No.1
When therapeutic irradiation is indicated for the orbital tumors, the greatest concern is the risk of radiation-induced cataract. Conjunctival lymphoma is one of the good examples. We would like to report the procedure of the lens shielding device(L.S.D) and the result of irradiated dose to the lens. L.S.D. consistes of two parts : load alloy to attenuate electron beam, and dental acryl which completely covers the lead alloy to avoid discomfort of cornea from contacting directly with cerrobend and side scattering by cerrobend. And for easy location and removal, side bars were made on each side. Radiation doses were meaured with TLD(TLD 3500 Hawshaw). Markus chamber in a polystyrene phantom. The phantom was irradiated with 9MeV electron beams from Clinac 2100C with $6{\times}6cm$ electron cone. The relative dose at 6mm depth where the lens is located was $4.2\%$ with TLD and $5.1\%$ with Markus chamber clinically when 2600 cGy are irradiated to the eyeball, the mapinary dose to the lens will be 109 cGy or 132 cGy, which will significently reduce the cataract.
마우스 신경모세포종 모델을 이용한 HSV-TK 유전자 치료에서 Bystander 효과 및 증폭에 관한 연구
조현상,김문규,박종영,Cho, Hyun Sang,Kim, Moon Kyu,Park, Chong Young 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.3
목 적: 본 연구에서는 in vitro 및 in vivo에서 HSV-TK 유전자 치료의 bystander 효과 및 기전을 관찰하고, 싸이토카인 유전자의 병합 치료가 bystander 효과를 증폭시킬 수 있는지 조사하여 그 결과를 향후 신경모세포종 치료에 적용하고자 본 연구를 시행하였다. 방 법: A/J 마우스 신경모세포종 모델에서, neuro-2a/TK 세포와 unmodified neuro-2a세포를 여러 비율로 혼합하여 접종한 후 GCV를 투여하여 종양의 크기 변화 및 생존 유무를 관찰하였다. 마우스 신경모 세포종에서 bystander 효과의 기전을 알아보기 위해 neuro-2a/TK 세포를 주입한 마우스의 조직을 절개하여 connexin 43, CD4+ 및 CD8+ 세포 침윤을 관찰 하였다. 10% 및 25% HSV-TK 투여 군에서 neuro-2a/IL-2 세포의 투여가 bystander 효과를 증폭시키는 지 조사하였다. 결 과 : 1) in vitro 및 in vivo에서 bystander 효과는 뚜렷하게 관찰되었다. 2) 마우스 신경모세포종의 면역 조직 화학 염색 검사에서 connexin 43 발현은 관찰되지 않았으나 많은 수의 CD4+ 및 CD8+ T 세포의 침윤이 관찰되었다. 3) 10% 및 25% HSV-TK 투여군의 마우스에서 neuro-2a/IL-2 세포의 투여는 대조군과 비교하여 종양의 성장을 더 억제 시켰다. 결 론: In vitro 및 in vivo에서 HSV-TK/GCV 유전자 치료의 bystander 효과는 뚜렷하였으며, 그 기전으로 면역 세포가 중요한 역할을 할 것으로 추측된다. 그리고 bystander 효과는 IL-2 투여에 의해 증폭됨을 확인하였다. 이는 향후 신경모세포종의 수술 후 잔존암 치료에 HSV-TK/GCV 유전자 치료가 이용 가능할 것으로 생각된다. Purpose : Selective introduction of genes conferring chemosensitivity into proliferating tumor cells may be used to treat cancer. We first investigated the bystander effect of retrovirus-mediated gene transfer of herpes simplex virus thymidine kinase(HSV-TK) gene to murine neuroblstoma cell line(neuro-2a) in vitro and in vivo. Second, we examined the mechanism and its enhancement of the bystander effect in murine neuroblastoma. Methods : To investigate the bystander effect, we studied tumor growth and survival time after HSV-TK/ganciclovir(GCV) treatment in a syngenic A/J mouse neuroblastoma model by mixing various ratios of HSV-TK-expressing neuro-2a cells with wild type neuro-2a cells followed by GCV treatment. To investigate the mechanism of the bystander effect in murine neuroblastoma, immunohistochemistry using connexin 43, CD4 and CD8-specific monoclonal antibodies was analyzed. We studied whether IL-2-secreting neuro-2a cells(neuro-2a/IL-2) would potentiate the bystander effect. Results : A strong bystander effect was observed in vitro and in vivo. The bystander effect in murine neuroblastoma was dependent on the immune response rather than connexin-mediated gap junction. Neuro-2a/IL-2 treatment enhanced the bystander effect in the HSV-TK/GCV system in murine neuroblastoma model. Conclusion : We conclude that the bystander effect in murine neuroblastoma depends on immune response and is enhanced by neuro-2a/IL-2.
컴퓨터그래픽 : 아날로그 제약 조건을 고려한 집적회로의 레이아웃 자동화
조현상(Cho Hyun Sang),김영수(Kim Young Soo),오정환(Oh Jeong Hwan),윤광섭(Yoon Kwang sub),한창호(Han Chang Ho) 한국정보처리학회 1997 정보처리학회논문지 Vol.4 No.8
A layout automation system for analog integrated circuits is proposed. The implemented system performs full-custom analog layout under the analog layout constraints. In order to overcome the demerits of conventional analog layout systems, parameterized module library is proposed. The system can support complex analog layout modules, resulting in a maximum expandability of the system. Moreover, modified dynamic multi-path algorithm is developed by enhancing the conventional Dijkstra algorithm. Several benchmark circuits such as comparator, op amp, and filter was tested by the system. Layout results compared to OPASYN show well-merging layout and interdigitized layout module.
데이터주도 임상 서비스를 위한 사용자 활동기반 의료진단지원시스템
조현상(Hyun Sang Cho),김성은(Sung Eun Kim),이고은(Ko-Eun Lee),오수아(Su A Oh),김정의(Jeong Ui Kim) 한국정보과학회 2021 정보과학회 컴퓨팅의 실제 논문지 Vol.27 No.5
정보통신기술과 IoT의 발달은 병원에서만 이루어지던 진료와 치료의 영역을 가정을 포함한 영역으로 확장하여 얻어지는 방대한 데이터를 이용하여 질병의 발생을 예측하고 방지하는 4P(Personalized, Participatory, Predictive, Preventive) 정밀 의료를 가능하게 한다. 생활패턴에서 얻을 수 있는 사용자의 활동정보는 내적, 외적인 요인에 의해 발생한 질병에 의해 영향을 받을 수 있으며, 특정한 질병은 특정한 사용자 활동에 영향을 미치게 된다. 본 논문은 의료진단을 지원하고 interactive 서비스와 결합하여 질환의 치료를 포함한 cybernetics system으로 활용될 수 있는 사용자 활동 데이터 기반의 의료 서비스 시스템의 개념모델을 제안한다. The development of information and communication technology and IoT enables 4P (personalization, participation, prediction, and prevention) precision medicine that predicts and prevents diseases by using vast amounts of data obtained by expanding the diagnosis and treatment areas of hospitals into homes. It is hypothesized that the user"s activity data, which can be obtained from the living patterns, may be affected by disease due to certain internal and external factors. Moreover, a specific disease affects a specific user activity. In this paper, we propose a conceptual model of a medical service system based on the user"s activity data that supports medical diagnosis and can be used as a cybernetics system for digital therapeutics in combination with interactive services.
가족력 유무에 따른 알코올 의존 환자의 성격 특성 및 충동성
조현상(Hyun-Sang Cho),노규식(Gyu-Sik Roh),김주희(Joo-Hee Kim),천덕희(Duk-Hee Cheon),유상우(Sang-Woo Yoo),남궁기(Kee Namkoong),유계준(Kae-Joon Yoo) 한국중독정신의학회 1998 중독정신의학 Vol.2 No.2
This study was designed to examine the differences in personality characteristics and impulsivity of male alcoholics according to their familial history of alcoholism. The clinical interview for demographic data, drinking history, and family history, and then, the MMPI, Impulsivity test, Cognitrone were performed in 75 psychiatric inpatients with alcohol dependence. The mean age for their first drinks was significantly younger and the average maximum amount consumed per drinking occasion was significantly greater in familial alcoholics than in nonfamilial alcoholics. The T-score of anti-social personality scale in MMPI was also significantly higher in familial alcoholics than in nonfamilial ones. However, there were no significant differences in the clinical scales of the MMPI or the scores on the Impulsivity test, and Cognitrone between familial alcoholics and nonfamilial ones except that some cognitive impairment was suggested in familial alcoholics. This study showed that familial alcoholics had a greater tendency for antisocial personality and the fine cognitive impairments, but not any more impulsivity compared to non-familial alcoholics. Therefore, differential treatment strategies according to familial alcoholic history will be needed.