초음파 위배출 측정과 한의설문 간의 상관성 분석

조수호,이재홍,고석재,김진성,박재우,Cho, Soo-ho,Lee, Jae-hong,Ko, Seok-jae,Kim, Jin-sung,Park, Jae-woo 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.4

Objective: This study was designed to investigate the correlation between gastric emptying measurement by ultrasonography and the findings of various questionnaires of functional dyspepsia (FD) or in Korean medicine to explore the possibility of quantification of questionnaires. Methods: Eighty-eight patients (44 patients with FD and 44 healthy controls) were recruited from October 2016 to November 2017. Gastric emptying half-time (T1/2) was measured by ultrasonography at fasting, and at 0, 15, 30, 45, 60, 90, and 120 min after meals (apple juice, 500 ml, 224 kcal). The average half-time (average T1/2) was calculated by averaging all measured half-times. A visual analogue scale (VAS), food retention questionnaire (FRQ), damum questionnaire (DQ), cold and heat questionnaire (CHQ), deficiency and excess questionnaire (DEQ), spleen-qi deficiency questionnaire (SQDQ), Nepean dyspepsia index-Korean version (NDI-K), and quality of life of NDI (NDI-QoL) were filled out by all participants. Correlation between the average T1/2 and questionnaires were analyzed for 79 patients (37 patients with FD and 42 healthy controls) after excluding missing and erroneous data. Results: The FRQ, DEQ, SQDQ, NDI-K, and NDI-QoL scores, especially for some gastrointestinal symptoms and general weakness-related symptoms, showed statistically significant correlations with average T1/2. Conclusions: Our results suggest that gastric emptying measurement by ultrasonography may be a quantitative substitute method for some Korean medical questionnaires or for some dyspepsia-related and deficiency-related items among them. However, further studies using various measurements of gastric emptying will be needed.

선천성 비루관 폐쇄에 대한 단계별 치료의 효과

조수호 ( Soo Ho Cho ),곽미선 ( Mi Seon Kwak ) 대한안과학회 2002 대한안과학회지 Vol.43 No.12

V 약침 및 한방치료로 호전된 서혜부 다한증 환자 1례

조수호 ( Soo-ho Cho ),이재홍 ( Jae-hong Lee ),고석재 ( Seok-jae Ko ),박재우 ( Jae-woo Park ) 면역약침의학회(구 대한면역약침학회) 2017 대한면역약침학회지 Vol.6 No.1

Objectives : The aim of this study is to report the effect of V Pharmacopuncture and Korean medicine treatments on primary focal hyperhidrosis at the inguinal region in a male patient. Methods : Thirty-one years old male patient who had focal hyperhidrosis at the inguinal region was managed by V Pharmacopuncture at Zunyang [前兩. both side of Hoeeum (CV1. 會陰)] about 5 times per week, herbal medicine decoction Hyeongbangjihwang-tang 3 times per day, herbal medicine Eunhwasagan-tang 3 times per day and acupuncture treatment once a day for 25 days of hospitalization treatment. Results and Conclusions : After 25 days of Korean medicine treatments with V Pharmacopuncture during hospitalization, hyperhidrosis and eczema at the inguinal region was markedly improved.

한의 복합치료로 호전된 불응성 위식도역류질환 (PPI-refractory GERD) 환자 1례 - 복진소견 평가를 중심으로 -

이재홍,조수호,고석재,박재우,Lee, Jae-hong,Cho, Soo-ho,Ko, Seok-jae,Park, Jae-woo 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.5

This case report describes a 60-year-old man who had reflux symptoms despite treatment with proton pump inhibitors (PPIs). Korean traditional medicine, including a herbal prescription, acupuncture, and moxibustion was administered to the patient during his 19 days of hospitalization. The visual analogue scale (VAS), gastrointestinal scale (GIS), and gastrointestinal symptom rating scale (GSRS) scores were assessed on the dates of admission and discharge. An abdominal examination, which is one of the Korean medicine diagnostic tools, was performed every day to evaluate the treatment progress. During the treatment, the improvement of symptoms was clinically correlated with abdominal examination outcomes. We suggest that administration of traditional Korean Medicine on PPI-refractory GERD patients could be effective and we recommend utilization of the abdominal examination as an assessment tool for Korean Medicine treatment.

한의 복진 정량화 연구 - 기능성 소화불량 환자의 복냉 진단을 중심으로 -

이재홍,조수호,고석재,김진성,박재우,Lee, Jae-hong,Cho, Soo-ho,Ko, Seok-jae,Kim, Jin-sung,Park, Jae-woo 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.4

Objective: This study was designed to investigate the possibility of quantification of the diagnosis of abdominal coldness (AC) in patients with functional dyspepsia (FD). Methods: Forty-four patients with FD were enrolled in this study. Three Korean medicine doctors each randomly examined all abdomens. Diagnosis of AC was made by consensus of at least two of the doctors. Body temperature (oral by digital oral thermometer) and skin temperature (by digital infrared thermal imaging [DITI]) were measured, followed by administration of the Cold and Heat questionnaire (CHQ) and the Instrument of Pattern Identification for Functional Dyspepsia (IPIFD). Results: Of the 44 patients with FD, 22 were assigned to the AC group and 22 to the non-AC group. The concordance rate of diagnosis among the three doctors was 63.6% (28/44), with a ${\kappa}$ of 0.504, indicating means moderate agreement). Neither the oral nor the skin temperatures showed statistically significant differences between the AC and non-AC groups. However, the CHQ scores and 'Simultaneous Occurrence of Cold and Heat Syndromes pattern' scores of the IPIFD were higher in AC group and showed statistically significant differences (p=0.010 and 0.009). Conclusions: This is the first study conducting quantitative measurements of abdominal coldness in patients with FD. Although oral and skin temperature showed no statistical significance between AC and non-AC groups, the concordance rate of diagnosis of AC among the three Korean Medicine doctors was moderate. The CHQ scores and 'Simultaneous Occurrence of Cold and Heat Syndromes pattern' scores of the IPIFD also suggest that diagnosis of AC is relevant to cold and heat patterns, and these questionnaires could be utilized as supportive data for the diagnosis of AC. Further studies should be conducted for the purpose of quantifying and standardizing abdominal examinations in Korean Medicine.

불인성 암성 통증의 비파괴적 수술

김성호 ( Seong Ho Kim ),최병연 ( Byung Yon Choi ),조수호 ( Soo Ho Cho ) 영남대학교 기초/임상의학연구소 2007 Yeungnam University Journal of Medicine Vol.24 No.2S

Pain is probably one of the most common cancer symptoms. In addition to being a major source of suffering and disability, cancer pain is extremely frightening for patients and their families. The authors propose to adjust the World Health Organization (WHO) pain management ladder from its current three-step approach to a more sophisticated five-step algorithm that includes physical and psychological modalities along the entire continuum of care and adds two more steps related to neuromodulative and neurodestructive procedures once the opioids fail. This review discusses the current surgical options for treating cancer pain, focusing on the continuous drug infusion pump currently available and briefly exploring some of the other surgical options for pain management. The introduction of intrathecal opioid administration for intractable cancer pain is considered as one of the most important breakthroughs in pain management. Morphine, the only opioid approved by FDA for intrathecal administration, has been increasingly utilized for this purpose.

요통의 해부학적 이해

김성호 ( Seong Ho Kim ),조수호 ( Soo Ho Cho ) 영남대학교 기초/임상의학연구소 2007 Yeungnam University Journal of Medicine Vol.24 No.2S

The sinuvertebral nerve(SVN) supplies the laterodorsal outer annulus of the intervertebral disc, the posterior longitudinal ligament(PLL), the anterior 2/3 of the dural sac and the anterior vascular plexus. Many blood vessels pass through the lateral neural canal: the anterior and posterior spinal canal branches, anterior and posterior radicular branches, and veins of the anterior and posterior internal vertebral venous plexus. The PLL is assumed to play an important role in proprio- and nociception. In the neighborhood of the SVN, other small branches emanate from the rami communicantes and join the dorsal ramus and the segmental artery that enters the neural canal. The sympathetic nerve plexus inside the anterior longitudinal ligament and the SVNs provide a network of nerve fibers around the vertebral bodies and intervertebral discs. These pathways explain the sympathetic component of the innervation of a number of spinal structures. The dorsal ramus innervates the facet joints at the corresponding level and one below, before it gives off muscular and cutaneous branches.

백서의 가역성 뇌허혈 모형에서 재관류 시간에 따른 뇌경색 크기의 변화

정병우,최병연,조수호,김오룡,배장호,김성호,Jung, Byoung Woo,Choi, Byung-Yon,Cho, Soo-Ho,Kim, Oh-Lyong,Bae, Jang-Ho,Kim, Seong-Ho 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.9

Objective : The purpose of the present study was to determine the appropriate time of clinical intervention by observing and analyzing the changes in the size of infarct, penumbra and cerebral edema and the extend of neurological deficit due to reperfusion damage according to time in a reversible cerebral ischemic model of reperfusing blood flow after inducing ischemia by maintaining middle cerebral artery occlusion for 2 hours(h) in rats. Methods : The rats were divided according to reperfusion time into control group(0 h reperfusion time) and experimental groups(0.5, 1, 2, 3, 4, 5, 6, 12, and 24 h of reperfusion time). Results : Changes in the size of infarction due to reperfusion damage were 0.93, 1.48 and 1.16% at 0.5, 1 and 2 h after reperfusion, respectively, and although a statistical significance was not present compared to 1.35% of the control group, damages increased drastically up to 6 h(6.64%), and the size increased were 6.65 and 6.78% at 12 and 24 h, respectively. Also there was no significant difference after 6 h up to 24 h in the size of infarction. In the areas where infarction occurred, reperfusion damage increased significantly with time in cortex than in subcortex. Accordingly, the size of penumbra area also showed a statistically significant decrease from 2 h up to 6 h after reperfusion, and 6 h after reperfusion, the area almost disappeared, becoming permanent infarction. Thus, reperfusion damage showed a significant increase from 2 h up to 6 h after reperfusion, and became steady thereafter. As for the mean ratio of the extend of cerebral edema, the control group and reperfusion 0.5 h group were 1.073 and 1.081, respectively ; up to 2 h thereafter, the ratio decreased to 1.01 but increased again with time ; and in reperfusion 12 h and reperfusion 24 h, the ratios were 1.070 and 1.075, respectively, showing similar size with that of control group. As for neurological deficit scores, the score of the control group was 2.67, that of reperfusion 2 h was 2, those of reperfusion 3 h and 6 h groups were 3.2 and 3.8, respectively, and those of reperfusion 12 h and 24 h groups were 4.2 and 4.6, respectively. Thus, as for the test results, the neurological deficit increased with time 2 h after reperfusion, and in reperfusion 12 and 24 h groups, almost all the symptoms appeared. Conclusion : As shown in these results, although the changes in the size of infarction due to reperfusion damage did not increase up to 2 h after reperfusion in the experimental groups compared to the control group, damage increased significantly thereafter up to 6 h, and the size remained about the same from 6 h to 24 h after reperfusion, becoming permanent infarction ; thus, the appropriate time of intervention according to the present study is at least 6 h before after maintaining reperfusion, including the time of cerebral artery occlusion.

다분절 경추 유합 및 내고정 수술결과

전우열,배장호,정병우,김성호,김오룡,최병연,조수호,Jeon, Woo-Youl,Bae, Jang-Ho,Jung, Byoung-Woo,Kim, Seong-Ho,Kim, Oh-Lyong,Choi, Byung-Yon,Cho, Soo-Ho 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.1

Objective : The purpose of the present study was to examine neurologic changes, fusion rate and degree of kyphosis from the surgical results of those patients who underwent multi-level anterior interbody fusion and internal fixation. Methods : Among 63 cases of the patients who received multi-level anterior interbody fusion and internal fixation in 5 years between 1995 to 1999 at the neurosurgery department, we performed a retrospective study in 52 cases that could be followed up with dynamic view imaging ; the results were compared and analyzed. The analysis was based on the results of history taking, physical findings and radiologic findings, and Odom criteria were used to classify those cases with neurologic changes. Results : Among those 52 cases in whom the follow-up was possible for at least a year and dynamic view imaging was possible, bone fusion was seen in 93% of the trauma cases and 95% in the non-trauma cases and overall bone fusion was observed in 94% of the cases. Bone fusion was seen in 93% of the autobone cases, 95% of the allobone cases, and 94% of the Mesh cases. Radiologic changes were observed by comparing the lateral view after surgery ; kyphosis was seen in 53% of the autobone cases, in 70% of the allobone cases, and in 35% of Mesh cases ; in 45% and 60% of the non-trauma cases and trauma cases, respectively ; and in 55% of the 2 level fusion cases and 46% of the 3 level fusion cases. Neurologic changes classified according to Odom criteria showed excellent result in 48% of all the cases, good in 23%, fair in 4%, and poor in 25%. Conclusion : Even those cases with multi-level fusion, a high fusion rate could be obtained by performing anterior interbody fusion and internal fixation ; those cases with kyphosis were related more with the presence or absence of posterior compartment injury rather than the fusion level ; and those trauma cases showed not much difference in the fusion rate compared with non-trauma cases but had a high possibility of kyphosis.

재발하였거나 수술적 제거가 불가능한 뇌수막종에 대한 Hydroxyurea 치료 - Preliminary Report -

이정환,김오룡,김성호,배장호,최병연,조수호,Lee, Jeong-Hwan,Kim, Oh-Lyong,Kim, Seong-Ho,Bae, Jang-Ho,Choi, Byung-Yon,Cho, Soo-Ho 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.1

1988년 1월부터 1997년 12월까지 본 교실에 내원하여 뇌수막종으로 진단받고 수술요법을 실시한 87례 중, 완전제거 후 재발한 경우와 부분적 절제후 방사선 치료를 받은 4례를 대상으로 hydroxyurea를 이용해 치료한 결과를 분석하였다. 남자가 1례, 여자가 3례이었으며 연령 분포는 23세에서 55세였다. 조직학적으로 3례가 meningothelial type이었으며 1례는 angiomatous type이었다. 3례에서 소뇌교각부에 발생하였으며 1례에서 해면정맥동에 발생하였다. 모든 환자들은 수술적 치료를 시행받았으며 3례의 환자에서 방사선 치료를 시행하였다. Hydroxyurea를 20mg/kg/day용량으로 투여하였으며 평균 추적관찰기간은 34개월이었다. 치료기간중 4례에서 종양이 줄어든 예는 없었으나 종양이 성장하지는 않았다. 삼차신경통 증상이 있던 1례는 증상 호전 되었으며 수술적 치료를 3차례 받았던 1례에서 두개골절제부위에 팽창되어 있던 뇌는 축소되어 두개강내로 복귀되었다. 혈액학적 부작용으로 백혈구 수치가 1례에서 감소되었으나 2주정도 복용을 중단한 후 다시 수치는 회복되었고 다른 심각한 부작용은 나타나지 않았다. 저자들은 뇌수막종 환자중, 수술후 재발한 경우와 불완전 제거를 시행한 경우 보조적 치료방법으로 hydroxyurea의 사용하여 종양크기의 감소는 없었으나 성장을 억제할 수 있었으며 앞으로 오랜 기간 추적관찰과 많은 증례에 대한 분석을 함으로써 뇌수막종 치료의 보조 방법으로 hydroxyurea를 이용할 수 있을 것으로 생각된다. Objectives : The present study was performed to analyze results of hydroxyurea treatment for unresectable and recurrent meningiomas as adjuvant chemotherapeutic agent. Material and Methods : Among 87 cases of meningioma patients who treated surgically between Jauary 1988 and December 1997 in our department, unresectable and recurrent cases were 4 cases. Histologically, 3 cases were meningothelial type, 1 case was angiomatous type. Tumor orgin was cerebellopontine angle(CPA) in 3 cases, cavernous sinus in 1 case. Three of 4 cases received radiation treatment. All patients received a daily dosage of 20mg/kg/day of hydroxyurea. Hematological monitorning was performed monthly and tumor measurement was assessed by MR imaging before treatment and every 6 months. Mean follow-up period was 34 months. Rerults : All cases showed no enlargement of tumor mass without any shrinkage. Trigeminal neuralgia in 1 case was improved and external herniation of brain on craniectomy site in 1 case was shrunken. None of the patients had any serious side effects. White blood cell count fell below $3000/{\mu}l$ in 1 case, but recovered 2 weeks later with cessation of medication. Conclusion : Hydroxyurea stopped cell growth by triggering the apoptotic cascade. Our preliminary data indicate that hydroxyurea provides adjuvant medical treatment in patients of unresectable and recurrent meningiomas