RISS 검색 - 국내학술지논문

1
Glycyrrhizin 및 감초엑스제제의 생체이용성에 관한 연구

조내규,김재백 圓光大學校藥品硏究所 1990 藥品硏究所報 Vol.5 No.1
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The pharmacokinetic characteristics of glycyrrhizin was examined using rabbits with i.v. injection of glycyrrhizin. And the present study was carried out to elucidate the difference in the concentration of glycyrrhizin in the rabbit plasma and its absorption after oral administration of glycyrrhizin, licorice exract, licorice exract granule (used Avice)?? as diluent : SEG-A) and commercial licorice extact granule(used lactose and corn starch as diluents : SEG-L). The concentration of glycyrrhizin in the plasma was determined by high performance liquid chromatography. As a result, the plasma decay in the rabbits following i.v. dose 100㎎/㎏ of glycyrrhizin was biphasic (A=1563.11±215.09μg/ml, α=8.07±4.59 hr, B=915.48±97.39μg/ml, β=0.121±0.03 0hr^-1). The time required for a maxium concentration (T_max) of glycyrrhizin was 6hrs after administration of glycyrrhizin. On the other hand, the T_max of giveyrrhizin was about 8 hrs after administration of licorice exract, LEG-A and LEG-L. The C_max of glycyrrhizin in the plasma after administration of glycyrrhizin, licorice exract, SEG-A and LEG-L was each 15.63±3.2, 11.38±1.7, 10.38±2.1 and 9.06±1.9μg/ml. The AUC of glycyrrhizin after the oral administration of glycyrrhizin was almost the same as that of licorice exract and LEG-A. But the AUC of glycyrrhizin after administration of LEG-L was significantly smaller than that of the others.
2
Paraquat 유도 폐독성에 대한 Flavonoid류의 독성경감 효과

최병기,조내규 환경독성보건학회 1995 환경독성보건학회지 Vol.10 No.3
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To investigate and evaluate the scavenging and antioxidative effects of various ftavonoids on paraquat induced pulmonary toxicity, in vivo and vitro tests of eight flavonoids(catechin, epicatechin, flayone, chrysin, apigenin, quercetin, morin and biochanin A) were carried out. In vitro test, inhibitory and antioxidative effects of lipoxygenase dependent lipidperoxidation, NADPH dependent cytochrome p-450 reductase to liver and lung microsome and superoxide anion production in rat peritoneal exudated macrophage were studied. In vivo test, biochemical parameters and cell population in bronchoalveolar lavage fluid(BALF) in mouse and rats after administration of paraquat and flavonoids were tested. The results are summerized as follows; 1. All flavonoids tested inhibited on NADPH dependent cytochrome p-450 reductase in liver and lung microsome. 2. All flavonoids tested showed the inhibitory effects on the superoxide anion production in rat peritoneal exudated macropharge. 3. Lactate dehydrogenase, acid phosphatase and total protein in BALF of mouse which increased by the administration of paraquat, decreased significantly by catechin, chrysin, morin and biochanin A. 4. Numbers of alveolar macropharge and PMN in BALF of rats which increased by the administration of paraquat decreased by all the tested flavonoids. Therefore, all flavonoids tested showed the useful compounds for scavenger and antioxidant on paraquat induced pulmonary toxicity.
3
Paraquat 유도 폐독성에 대한 Flavonoid류의 독성경감 효과

최병기,조내규 한국환경독성학회 1995 환경독성보건학회지 Vol.10 No.2
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  DBpia
  
  DBpia
To investigate and evaluate the scavenging and antioxidative effects of various flavonoids on paraquat induced pulmonary toxicity, in vivo and vitro tests of eight flavonoids(catechin, epicatechin, flavone, chrysin, apigenin, quercetin, morin and biochanin A) were carried out. In vitro test, inhibitory and antioxidative effects of lipoxygenase dependent lipidperoxidation, NADPH dependent cytochrome p-450 reductase to liver and lung microsome and superoxide anion production in rat peritoneal exudated macrophage were studied. In vivo test, biochemical parameters and cell population in bronchoalveolar lavage fluid(BALF) in mouse and rats after administration of paraquat and flavonoids were tested. The results are summerized as follows; 1. All flavonoids tested inhibited on NADPH dependent cytochrome p-450 reductase in liver and lung microsome. 2. All flavonoids tested showed the inhibitory effects on the superoxide anion production in rat peritoneal exudated macropharge. 3. Lactate dehydrogenase, acid phosphatase and total protein in BALF of mouse which increased by the administration of paraquat, decreased significantly by catechin, chrysin, morin and biochanin A. 4. Numbers of alveolar macropharge and PMN in BALF of rats which increased by the administration of paraquat decreased by all the tested flavonoids. Therefore, all flavonoids tested showed the useful compounds for scavenger and antioxidant on paraquat induced pulmonary toxicity.
4
Paraquat 유도독성에 대한 Flavonoid류의 독성경감효과

최병기,조내규 한국환경독성학회 1995 환경독성보건학회지 Vol.10 No.1
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  ScienceON
  
  DBpia
To investigate and evaluated the scavenging and antioxidative effects of various flavonoids on paraquat induced toxicity, in vivo and vitro tests of eight flavonoids (catechin, epocatechin, flavone, chrysin, apigenin, quercetin, morin and biochanin A) were carried out. The generation of reactive oxygen substances(ROS) in PMS-NADH system H>O, induced hemolysis and lipidperoxidation to blood, NADPH dependent lipidperoxidation to liver and lung microsome by paraquat were studied. The results are summerized as follows: 1) In the concentration ranges from 3.3 to 9.8μM of catechin,epicatechin, quercetin and biochanin A removed the 50% of DPPH radical scavenging effects. 2) In the concentration ranges from 0.60 to 1.86 mM of catechin, epicatechin, quercetin and biochanin A showed the inhibitory and antioxidative activity on superoxide anion which gernerated in PMA-NADH system. 3) In the concentration ranges from 0.12 to 0.49mM of catechin, epicatechin, quercetin and biochanin A showed the inhibitory and antioxidative activity on H₂O₂ which generated in PMA-NADH system. 4) In the concentration ranges from 0.6 x 10^(-5) to 6.3 x 10^(-6)mM of catechin, epicatechin, flavone, chrysin, quercetin and morin showed the inhibitory and antioxidative activity on H₂O₂, induced hemolysis to blood 5) All flavonoids tested exhibited inhibitory and antioxidative effects on paraquat induced liver and lung microsomal lipidperoxidation. Therefore, all flavonoids evaluated showed the useful compounds for scavenger and antioxidant on paraquat induced toxicity.

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