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Dextran Sulfate Sodium 장염 동물 모델에서 Benzoxazole 유도체인 B-98의 장염 예방 효과 및 T세포 분획 변화
송은미 ( Eun Mi Song ),정성애 ( Sung Ae Jung ),이종수 ( Jong Soo Lee ),김성은 ( Seung Eun Kim ),심기남 ( Ki Nam Shim ),정혜경 ( Hye Kyung Jung ),유권 ( Kwon Yoo ),박혜영 ( Hae Young Park ) 대한소화기학회 2013 대한소화기학회지 Vol.62 No.1
목적: 염증성 장질환의 염증반응에 많은 염증매개물질들이 관련하는데 이중 leukotriene은 강력한 염증 매개체로 leukotriene의 생성을 억제하는 5-lipoxygenase (5-LO) 억제제가 염증성 장질환의 치료제로 기대되어 왔다. 최근 새로운 5-LO 억제제로 benzothiazole 유도체인 B-98이 개발되어, 이번 연구는 이 약제를 장염 동물 모델에 투여하여 임상 양상 및 조직학적 변화를 확인하고 interleukin (IL)-6, tumor necrosis factor (TNF)-α와 CD4+ T세포 분획의 변화를 측정하여 B-98의 치료 효과를 알아보고자 하였다. 대상 및 방법: C57BL/6 마우스를 정상 대조군, dextran sulfate sodium (DSS) 장염군, B-98 저용량 투여군(20 mg/kg), B-98 고용량 투여군(100 mg/kg)으로 나누고 3% DSS을 복용시켜 장염을 유발하였으며, B-98은 하루에 한번씩 복강 내로 주사하였다. 장염의 평가는 disease activity index (DAI), 장길이, 조직학적 점수 체계(histologic colitis scoring system) 를 이용하였다. 대장 조직의 IL-6를 RT-PCR을 이용하여 측정 하였고 소장 고유층 세포를 분리하여 CD4+ T세포를 유세포 분석하였다. 결과: B-98 투여군에서 DSS 장염군에 비하여 DAI, 조직학적 점수가 유의하게 낮았으며(p<0.01) 통계적 유의성은 없었으나 장 길이도 더 긴 경향을 보였다. DSS 장염군에서 정상 대조군에 비하여 IL-6 수치가 유의하게 증가했으며(p<0.05), B-98 투여군에서 IL-6 수치가 유의하게 감소하였다(p<0.05). DSS 장염군에서 Th1 세포, Th9 세포, Th17 세포의 분획이 증가하였고 B-98 투여군에서 모두 유의하게 감소하였다(p <0.05). 결론: DSS를 이용한 장염 모델에서 새로운 5-LO 억제제인 B-98를 이용하여 장염의 염증 소견이 호전되고 IL-6가 감소한 것을 확인함으로써 장염 모델에서 B-98의 치료 효과가 있음을 제시하였다. 또한 DSS 장염 모델에서 Th1, Th9, Th17 세포 분획이 증가하였으며 B-98 투여시 감소하여 치료 효과가 Th1, Th9, Th17 세포의 면역작용과 관련이 있는 것으로 생각된다. 목적: 염증성 장질환의 염증반응에 많은 염증매개물질들이 관련하는데 이중 leukotriene은 강력한 염증 매개체로 leukotriene의 생성을 억제하는 5-lipoxygenase (5-LO) 억제제가 염증성 장질환의 치료제로 기대되어 왔다. 최근 새로운 5-LO 억제제로 benzothiazole 유도체인 B-98이 개발되어, 이번 연구는 이 약제를 장염 동물 모델에 투여하여 임상 양상 및 조직학적 변화를 확인하고 interleukin (IL)-6, tumor necrosis factor (TNF)-α와 CD4+ T세포 분획의 변화를 측정하여 B-98의 치료 효과를 알아보고자 하였다. 대상 및 방법: C57BL/6 마우스를 정상 대조군, dextran sulfate sodium (DSS) 장염군, B-98 저용량 투여군(20 mg/kg), B-98 고용량 투여군(100 mg/kg)으로 나누고 3% DSS을 복용시켜 장염을 유발하였으며, B-98은 하루에 한번씩 복강 내로 주사하였다. 장염의 평가는 disease activity index (DAI), 장길이, 조직학적 점수 체계(histologic colitis scoring system) 를 이용하였다. 대장 조직의 IL-6를 RT-PCR을 이용하여 측정 하였고 소장 고유층 세포를 분리하여 CD4+ T세포를 유세포 분석하였다. 결과: B-98 투여군에서 DSS 장염군에 비하여 DAI, 조직학적 점수가 유의하게 낮았으며(p<0.01) 통계적 유의성은 없었으나 장 길이도 더 긴 경향을 보였다. DSS 장염군에서 정상 대조군에 비하여 IL-6 수치가 유의하게 증가했으며(p<0.05), B-98 투여군에서 IL-6 수치가 유의하게 감소하였다(p<0.05). DSS 장염군에서 Th1 세포, Th9 세포, Th17 세포의 분획이 증가하였고 B-98 투여군에서 모두 유의하게 감소하였다(p <0.05). 결론: DSS를 이용한 장염 모델에서 새로운 5-LO 억제제인 B-98를 이용하여 장염의 염증 소견이 호전되고 IL-6가 감소한 것을 확인함으로써 장염 모델에서 B-98의 치료 효과가 있음을 제시하였다. 또한 DSS 장염 모델에서 Th1, Th9, Th17 세포 분획이 증가하였으며 B-98 투여시 감소하여 치료 효과가 Th1, Th9, Th17 세포의 면역작용과 관련이 있는 것으로 생각된다.
정혜경,김정근 한국보건통계학회 1982 한국보건정보통계학회지 Vol.7 No.1
In order to find out the awareness of parents on the causes of their mentally retarded children, a survey with questionnaire was carried out with 487 parents whose children are attending 7 special schools, from September 1st to 30th, 1982. The following results were obtained. Ⅰ. Of 487 children studied, male was 310 and female was 177. Ⅱ. I.Q of the children studied were classified as; custodial 4.7%, trainable 38.4%, educable 40.8% and unknown or unmeasurable 16.2% respectively. Ⅲ. Parity distribution of the 487 children studied were first 34.7%, second 25.3%, third 17.7% and over 4th 22.4% respectively. Ⅳ.Onset periods of mental retardation responded by parents studied were: hereditary 12.7%, fetal age 10.3%, at delivery 24.2%, infant age 21.4%, child age 11.0% and unknown 20.4% respectively. Ⅴ.Of 487 children studied, Down's syndrome was 12.7%. Relative risk of Down's syndrome was increased by age: 15-19 age group 0.00, 20-24 age group 0.20. 25-29 age group 0.61, 30-40 age group 0.82 and over-35 age group 2.75 respectively. Ⅵ. Of 487 parents studied, 10.3% responded that their children's mental retardation was occured in fetal age and the causes they responded were: medication 36.0%, eclamsia 28.0%, CO poisoning 8.0%, cardiac disease 8.0%, fainting 8.0%, infection 2.0%, others 10.0% respectively. Ⅶ. Of 487 parents studied, 24.2% responded that their children's mental retardation was occured at delivery. Under-weight baby was 7.0% and the baby delivered by disturbed delivery was 17.2%. Ⅷ. Of 487 parents studied, 21.4% responded that the causes of their children's mental retardation was occured in infant age and the causes they responded were: convulsion 34.6%, febrile disease 25.0%, meningitis 10.6%, measles 10.6%, jaundice 4.8%, medication 3.8%, brain under-development 3.8%, encephalitis 1.9%, Co poisoning 1.9% and others 2.9% respectively. Ⅸ. Of 487 parents studied, 11.0% responded that the causes of their children's mental retardation was occurred in child age and the causes they responded were: convaulsion 44.4%, meningitis 20.4% febrile disease 13.0%, measles 9.5%, encephalitis 7.4%, trauma or accident 3.7% and other 1.9% respectively.
정혜경,김종연 한국식생활문화학회 1997 韓國食生活文化學會誌 Vol.12 No.4
The purpose of this study was to investigate the current foodservice management practices of children care social welfare facilities. Questionnaire were sent to the directors of all 275 children welfare facilities in Korea and 107 returned facilities in korea and 107 returned the complete answers. These questionnaire were answered by manager. Equipments were evaluated by investigators using the evaluation form, staffing structure revealed that most of the facilities had a director, a secretary, nurse, but only 15% of the system hired a dietitian. It showed the shortage of nurse, physical therapists, and dietitian. Therefore, food purchasing, menu planning, food delivery, and the other food service management processes are handled by non-professionals, such as director, secretary, or cooks. Food purchasing money of total budget is 10∼20%. Food purchasing place in most facilities was market place. Foodstuffs were almost purchased 2∼3 per weeks. 90% of the welfare facilities were used the menu. Modified food frequency questionnaire were used to get the frequencies of each food items used in menu. The results showed relatively satisfactory in food frequencies, however, this was about what was used in menu, not what was eaten by the residents. Conditions of most equipments in the kitchen were defective specially in dishwashing and sterilization step.
서울 음식문화에 대한 연구 : 심층면접에 의한 사례 연구 The encounter between nutritional science and anthropology
이종미,조미숙,정혜경,이정혜 한국식생활문화학회 1996 韓國食生活文化學會誌 Vol.11 No.2
This study presents a sociocultural study of 'traditional' as well as contemporary dietary construtions among Seoulites. It also represents the first interdisciplinary study of food between nutritional science and anthropology in Korea. This study was performed a case study based on in- depth interviews with those who were born around the Japanese occupation period and raised in Seoul experiencing radical social changes modern Korean history. The participants were mostly in their late sixties and very knowledgeable of 'traditional' foods of Seoul and the ways they were made and consumed. This interview data show the historicity of foods were used and understood differently in past and represented different understandings of, for instances, 'nature' and 'culture' of Seoulites. This study not only provides new approaches to food study but also identifies the common ground on which an interdisciplinary study of food between nutritionists and anthropologists can develop.