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NF-kB Family Transcription Factors
Chung, Pa Jin,Hwang, Kyung Kon,Kim, Hong Hee 朝鮮大學校 口腔生物學硏究所 1999 Oral Biology Research (Oral Biol Res) Vol.23 No.1
NF-κB is a eucaryotic transcription factor that exists in virtually all cell types. More than a decade after its discovery, remains an exciting and active area of study. A primary level of control for NF-κB is through interactions with an inhibitor protein called IκB. recent evidence confirms the existence of multiple forms of IκB that appear to regulate NF-κB by distinct mechanisms. NF-κB can be activated by exposure of cells to LPS or inflammatory cytokines such as TNF or IL-1, viral infection or expression of certain viral gene products, UV irradiation, B or T cell activation, and by other physiological and nonphysiological stimuli. Activation of NF-κB to move into the nucleus is controlled by the targeted phosphorylation and subsequent degradation of IκB. Exciting new research has elaborated several important and unexpected findings that explain mechanisms involved in the activation of NF-κB. In the nucleus, NF-κB dimers bind to target DNA elements and activate transcription of genes encoding proteins involved with immune or inflammation responses and with cell growth control.
이홍찬,정파진,이장희 朝鮮大學校 口腔生物學硏究所 2002 Oral Biology Research (Oral Biol Res) Vol.26 No.1
Osteoclasts, cells primarily involved in osteoporosis, are originated from the hematopoietic precursor cells of the monocyte/macrophage lineage. Proteins involved in osteoclast differentiation could be targets for drug development of osteoporosis therapy. To characterize protein expression pattern during osteoclastogenesis, we have carried out two-dimensional electrophoreses using cellular extracts form RAW 264.7 cells and mouse bond-marrow cells before and after differentiation into osteoclst-like cells. Several protein spots were found changed during differentiation. These data can serve protein expression maps for osteoclastogenesis and provide information for further analyses with MALDI-TOF for identification of the regualted proteins.
성선자극호르몬이 흰쥐 난소의 GnRH와 GnRH mRNA의 발현에 미치는 영향
백원영,정파진,박신근,김완영,이종학,김종화,김명옥,최완성,Paik, Won-Young,Chung, Pa-Jin,Park, Shin-Keun,Kim, Wan-Young,Lee, Jong-Hak,Kim, Jong-Hwa,Kim, Myeong-Ok,Choi, Wan-Sung 대한생식의학회 1994 Clinical and Experimental Reproductive Medicine Vol.21 No.1
Expression of gonadotropin releasing hormone(GnRH) has been described in the rat ovary. It remains, however, unkown whether GnRH is synthesized as a prohormone. Therefore, this study was performed to verify the expression of pro-GnRH by in situ hybridization and further to investigate the effect of gonadotropin on GnRH or GnRH mRNA in rat ovary by immunohistochemical and in situ hybridization techniques. Adult female Sprague-Dawely rats were used and the estrous cycle was synchronized by intraperitoneal injection of pregnant mare's serum gonadotropin(PMSG). Ovaries were fixed with 4% paraformaldehyde and embedded with G.C.T. compound and cut by cryostat. For immunohistochemistry, avidin-biotin peroxidase complex(ABS) method was employed and for in situ hybridization, $^{35}S$-end labeled oligonucleotide was used and followed by autoradiography. By in situ hybridization using GnRH oligomer and GAP(GnRH associated protein) oligomer, GnRH mRNA and GAP mRNA were co-localized in the fullicular cells, luteal cells, interstitial cells and theca cells. GnRH or GnRH mRNA signals in the ovary increased by human chorionic gonadotropin(hCG) injection. At the 3 and 6 hrs after hCG injection, the number of GnRH and GnRH mRNA containing cells increased rapidly and the density of GnRH and GnRH mRHA culminated at 9 hrs after heG injection. With the follicular development, the high expression of GnRH and GnRH mRNA was also observed within the follicles. After ovulation, the density of GnRH or GnRH mRNA decreased in the follicles but increased in the corpus lutea.
상현숙,정파진,김홍희 朝鮮大學校 口腔生物學硏究所 2002 Oral Biology Research (Oral Biol Res) Vol.26 No.1
The cDNA array technique was employed to analyse gene expression patterns during osteoclast differentiation form mouse bone marrow precursor cells. The following conclusions were drawn from the obtained results. 1. Cytokine receptors such as intrleukin-7 receptor alpha and insulin-like growth factor 1A. hormone precursors such as proopiomelanocortin, signaling molecules such as interferon regulatory factor 1 and PI3-K p85 alpha, transcription factors such as c-fos proto-oncogene, and cell cycle regulatory genes such as TIS21 early response gene increased during osteoclast differentiation. 2 TCRA enhancer-binding factor-interacting protein 1, proliferation-associated protein 1, prothymosin alpha, small inducible cytokine subfamily A member 7, prothymosin beta 4, and rho GDP dissociation inhibitor beta decreased during osteoclast differentiation. These genes have been shown to either mediate signaling pathways or regulate transcription. However, their involvement in osteoclast differentiation has not been reported. Some genes involved in cell cycle regulation such as G2/M-specific cyclin G. G2/M-specific cyclin A2. G2/M-specific cyclin B2. and cyclin-dependent kinase inhibitor 2D also decreased during osteoclastogenesis.