http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
정동섭 ( Dong Sup Chung ),홍용길 ( Yong Kil Hong ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2007 대한뇌종양학회지 Vol.6 No.1
Cytotoxic chemotherapy has been an important treatment modality in human malignancy as well as surgery and radiotherapy. Chemotherapeutic agents have continued to improve in efficacy, but there are few cases in which a single drug or treatment modality has sufficien+t activity to cure the malignancy by itself. The active immunotherapeutic strategy to induce an immune response against tumors is quite attractive because it offers the potential for high tumor-specific toxicity, minimal side effects, and a durable antitumor effect. However, its clinical effects on patients with malignancy have not been up to the expectation because of immune tolerance, sheer physical burden of tumor antigens, tumor escape mechanisms from the immune surveillance system and so on. Although the combined chemotherapy and immunotherapy would seem to be contradictory, preclinical and clinical data have shown that many chemotherapeutic agents such as cyclophosphamide, gemcitabine and temozolomide enhance the efficacy of immunotherapy when used prior to immunotherapy. Explainable mechanisms of action are lessening of inhibitory immune effect by tumors, improvement of the effector T cell:tumor ratio, inhibition of regulatory T cells, enhancement of antigen presentation by tumors, alteration of tumor microenvironment, or some yet unknown method. Recent developed targeted therapies such as the monoclonal antibodies cetuximab, bevacizumab and trastuzumab, seem to be more effective when given with chemotherapy or other targeted therapies. More experimental and clinical trials are needed to evoke the full potential of the synergistic antitumor effects of chemotherapy combined with immunotherapy.
오정재(Jung Jae Oh),정동섭(Dong-Sup Chung),윤완수(Wan-Soo Yoon) 대한두개저학회 2021 대한두개저학회지 Vol.16 No.2
Background : Primary orbital tumors are relatively rarely encountered by neurosurgeons. Several approaches to primary orbital tumors have been used depending upon the tumor location, preoperative diagnosis, and the surgeon’s experience. Here, we present our clinical experience with primary orbital tumors from a neurosurgical perspective. Methods : A total of 11 patients with primary orbital tumors who underwent surgical resections between January 2011 and December 2018 were included in the study. All clinical data, including preoperative symptoms, visual function, operation record, histopathology, and radiologic imaging were reviewed. Results : The median age of the patients was 55 years, and diplopia and impaired vision were the most common symptoms. Depending upon the tumor location in the orbit, the intraconal type was seen in eight patients, the intracanalicular type was seen in two, and the extraconal type was seen in one. Surgery on these tumors was performed by the transcranial approach in nine patients and the endoscopic endonasal approach in two, depending upon the meridian of the optic nerve. Gross total resection was completed in five patients, subtotal resection in one, partial resection in one, and biopsies in four. Postoperatively, visual function was improved in two of four (50%) patients, and preexisting vision was preserved in the other nine patients. Conclusions : Although the experience with primary orbital tumors was limited, we suggest that favorable surgical outcomes can be achieved with an appropriate surgical approach by understanding the anatomy of the orbit, especially the meridian of the optic nerve.
단일 분절 퇴행성 경추질환에서 Titanium Cage를 이용한 전방 융합술의 조기 치험 : 골편 이식을 동반하지 않은 경우의 임상적 방사선학적 초기 결과
이영균,한영민,김종태,정동섭,박영섭,박춘근,강준기,Lee, Young-Kyun,Han, Young-Min,Kim, Jong-Tae,Chung, Dong-Sup,Park, Young-Sup,Park, Chun-Kun,Kang, Joon-Ki 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.2
Objectives : Anterior cervical discectomy and interbody fusion has become a well-accepted surgical treatment of degenerative cervical diseases. Implatable cages have a stabilizing effect without plates and no need for autogenous bone graft. The authors evaluates the effect of implatable titanium cage(RABEA) on the clinical and radiological outcomes. Methods : 34 patients with symptomatic cervical degenerative diseases due to one level disc pathology were underwent anterior cervical discectomy and interbody fusion with titanium cages(RABEA) which were not filled with cancallous bone grafts from January 1999 to May 2001. Patients with osteoporosis and older than 65 years were not included. Among them, 15 patients could be followed-up for at least 1 year. The authors retrospectively reviewed the charts and radiographic data. Mean follow-up period was $1.3{\pm}0.2years$. Results : Clinical results according to the Odom's criteria was exellent and good in 14(93%) patients. One patient with fair result showed complete loss of the disc space height due to settlement of the cage. Preoperatively, the mean height of the disc space(${\pm}$standard deviation) was $3.42{\pm}1.10mm$(range 2.0-5.5mm), and at 1 day postoperatively it was $7.88{\pm}0.90mm$(range 6.50-9.0). The mean height of the disc space after 1 year was $6.50{\pm}1.38mm$(range 3.0-8.0). The restoration of the height was statistically significant(p<0.05). The mean height after 1 year was $82.7{\pm}15.9%$ of the height at 1 day postoperatively. Preoperatively the mean value of the cervical lodortic angle was $21.8{\pm}11.8^{\circ}$ and 1 year postopertively, it was $24.5{\pm}8.3^{\circ}$, which was statistically not significant. All patients showed no abnormal movements on flexion and extension lateral film after 6 months. Conclusion : Implantable titanium cages appear safe and effective in selected patients, and their use helps to avoid complications associated with bone graft harvest. Subsidence of the cage seems to be a potential risk factor for recurrence of the symptoms. For long-term results, a longer follow-up is required.
기초 : 악성신경교종의 세포고사체로 감작시킨 수지상세포에 의해 유도된 종양특이적 T 림프구의 HLA Type에 따른 세포독성
박익성 ( Ik Seong Park ),정동섭 ( Dong Sup Chung ),한영민 ( Young Min Han ),장경술 ( Kyung Sool Jang ),김종태 ( Jong Tae Kim ),박영섭 ( Young Sup Park ) 대한뇌종양학회 2008 대한뇌종양학회지 Vol.7 No.2
Objective:The purpose of this study is to determine whether human dendritic cells(DCs) pulsed with glioma apoptotic bodies(GABs) can induce tumor-specific T lymphocytes having cytotoxicities to allogeneic glioma cells matched or mismatched at class I human leukocyte antigen(HLA) loci. Methods:DCs were generated from peripheral blood mononuclear cells(PBMCs) of HLA-A2 positive healthy donors cultured in the presence of granulocyte macrophage-colony stimulating factor and interleukin(IL)-4. GABs from HLAA2 positive T98G glioblastoma cells following actinomycin D treatment were pulsed to DCs. CD8+ T lymphocytes isolated from PBMCs of the same donors were cultured in media containing IL-2 and were stimulated by GAB-pulsed DCs three times at weekly interval. Then cytolytic activities of these cytotoxic CD8+ T cells against HLA-A2 positive T98G and U87 glioblastoma cells, and HLA-A2 negative A172 glioblastoma cells were determined by a standard 4hr [51Cr]-release assay. Results:The average percentages of T98G , U87 and A172 cell lysis were 43.7%, 45.6% and 5.1% compared with 3.6% of controls at an effector to target cell ratio of 40:1 respectively. The cytotoxic T lymphocytes(CTLs) primed with HLAA2 positive T98G GAB-pulsed DCs had cytotoxicity to HLA-A2 positive T98G and U87 glioma cells but not to HLAA2 negative A172 cells(p<0.01). Conclusion:This study showed that tumor-specific CTLs generated by stimulations with GAB-pulsed DCs had cytotoxicity to the glioma cells in a HLA-restricted manner. This result suggests the feasibility of the use of HLA-matched allogeneic glioma cells as a source of antigens for patients not eligible for surgery in the DC-based immunotherapy.