http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Hgcl2 에 의한 다클론성 활성화에 의해 나타나는 생쥐의 면역반응 변화에 미치는 파치균 다당류의 영향
문창규(Chang Kiu Moon),목명수(Myung Soo Mock),전선덕(Sun Duck Chun),김진형(Jin Hyoung Kim),김강석(Kang Suk Kim),최청하(Chung Ha Choi),황지원(Ji Won Whang) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.4
Repeated injections of low-doses of mercuric chloride in rats or mice induce polyclonal activation which includes the induction of anti-glomerular basement membrane (GBM) antibodies and circulating immune complex and it results in nephritis. Because this disease is autoimmune mediated disease resulted from immune dysfunction, immunomodulators are used to control the symptoms or to cure the disease. Irpex lacteus Fr. is a kind of new medicinal fungus. The polysaccharide fraction extracted from submerged fermentation of Irpex lacteus Fr. decreased the serum agglutinin, serolysin and IgM plaque forming cells in normal mice. The hitherto obtained clinical results suggested that it significantly improved the oligourea, edema, and hypertension in patients who have nephritis. To elucidate the action-mechanisms of Irpex lacteus Fr., we established the experimental model of HgCl₂ induced polyclonal activation by intraperitoneal administrations of HgCl₂ to mice. To assess the immunomodulating effect of lrpex lacteus fraction, we investigated its effects on the mitogen induced proliferation and IgM PFC counts of splenic lymphocytes in mice during the treatment of HgCl₂. The Irpex lacteus polysaccharide reduced the abnormally increased mitogen induced lymphocyte proliferation and IgM PFCs to almost normal levels. And the Irpex lacteus polysaccharides prevented the increasement of serum immunoglobulin level induced by HgCl₂. These data suggested that the Irpex lacteus polysaccharides might have the immunomodulating activity to prevent and /or improve the HgCl₂ induced autoimmune disease.