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실비음(實脾飮)이 Zucker rat의 비만 및 항산화에 미치는 영향
전경택 ( Gyung Taek Jeon ),금동호 ( Dong Ho Keum ),이명종 ( Myeong Jong Lee ) 한방재활의학과학회 2003 한방재활의학과학회지 Vol.13 No.2
Objective : This study was carried out to examine the effect of Silbi-um(Shipi-yin, SBU) on obesity and antioxidation.Methods and Materials : SBU was investigated effects of obesity and antioxidation for DPPH radical ability, nitrate reductase activity, total body weight and fed ratio, serum glucose content, serum triglyceride and total cholesterol content, serum GPT and GOT content, serum leptin content, catalase activity, superoxide dismutase activity, lipidperoxidation and glutathione activity. In this experiment rats were divided into 4 group, Lean control; non-treated, Lean A; SBU, Fat; control: non treated, Fat A; SBU, Each value is the mean ± S.E for 3 separate experiments. Result and Conclusions : In vitro, DPPH radical ability and nitrate reductase activity were increased according to the increasing of SBU concentrations. In vivo, compared with Fat control group, the serum glucose content, the serum triglyceride content, the serum total cholesterol content the serum GPT and the serum GOT content were decreased in Fat A group. The serum leptin content was increased, too. Catalase activity and superoxide dismutase activity were increased and lipidperoxidation was decreased in Fat A group compared with Fat control group. Glutathione activity was not increased significantly. According to the above results, the obesity and the antioxidant activities of SBU were proved in experiment and it should be studied and developed more throughly.
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