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대한민국 육군훈련소의 상기도 호흡기 감염증 유행 차단을 위한 환경 및 매개물 소독 연구: 집단 무작위 대조 시험
오홍상 ( Hong Sang Oh ),고재훈 ( Jae-hoon Ko ),조동호 ( Dong Ho Jo ),박규은 ( Qu-eun Park ),권순환 ( Soon-hwan Kwon ),장해봉 ( Haebong Jang ) 국군의무사령부 2022 대한군진의학학술지 Vol.53 No.1
Objective: Human adenovirus type 55 (HAdV-55) is an emerging pathogen causing outbreak of pneumonia in Korean military since 2014. Since the vaccines are developed yet, nonpharmacological interventions (NPIs) including environmental disinfection may play a key role in controlling the outbreak. To evaluate effect of environmental disinfection, we conducted a randomized controlled trial in the Korea Army Training Center. Method: The study population included 60 companies of five regiments. The companies are divided into environmental disinfection company (intervention arm) and control company (control arm). The environmental disinfection company performed disinfection of environmental surfaces using 70% alcohol-based disinfectant and 2,000ppm sodium hypochlorite. The disinfection procedures were performed at the beginning and end of training. The control companies maintained routine hygiene procedures. For primary outcome, the number of patients with fever or acute upper respiratory infection per week is evaluated. Results: Study period included March 11, 2019 to June 9, 2019 and pre-intervention period included January 7, 2019 to April 14, 2019. The average numbers of weekly patient visit were 42.51 ± 9.21 persons in the intervention arm and 45.12 ± 9.38 persons (P-value = 0.281) in the control arm. Compared to the pre-intervention period, the average numbers of weekly patient visit during the intervention period were weakly decreased without statistical significance [2.1 ± 10.4 persons in the intervention arm and 7.45 ± 13.28 persons in the pre-intervention (P-value = 0.091)]. Conclusion: Although there is no statistical significance, fever or acute upper respiratory infections was reduced by intervention (environmental disinfection). Further defined controlled investigations for the effect of NPIs in controlling outbreaks of acute upper respiratory tract infection including HAdV-55 is needed.
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