제2형 당뇨병 환자에서 허혈성 뇌졸중 발생과 Interleukin-1 Receptor Antagonist 및 Peroxisome Proliferator-Activated $Receptor-{\gamma}2$ 유전자 다형성과의 관계

장원만,이병철,안세영,두호경,안영민,Jang, Won-Man,Lee, Byung-Cheol,Ahn, Se-Young,Doo, Ho-Kyung,Ahn, Young-Min 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.2

Objective : It has been reported that two-repeats ($IL1RN^{\ast}2$) of interleukin-1 receptor antagonist (IL-1Ra) gene is associated with ischemic stroke, and that Ala allele of the common Pro12Ala polymorphism in $PPAR-{\gamma}2$ isoform is associated with reduced risk for type 2 DM and its complications. The aim of the present study is to assess the association of IL-1Ra and $PPAR-{\gamma}2$ Pro12Ala polymorphism with the presence of ischemic stroke in the case of diabetic and non-diabetic patients. Methods : Genomic DNA was obtained from 373 healthy subjects, 157 DM subjects without ischemic stroke (known DM duration ${\ge}10$ years) and 302 ischemic stroke patients (including with DM). IL-1Ra polymorphism was analysed by polymerase chain reaction (PCR), and $PPAR-{\gamma}2$ polymorphism by restriction fragment length polymorphism after PCR. Results : $IL1RN^{\ast}1/IL1RN^{\ast}2$ genotype was associated with significantly increased risk for DM (OR=2.86, P = 0.0008) and ischemic stroke (OR=2.74, P = 0.0016). Pro/Ala genotype was associated with the reduced risk for DM (OR=0.53, P = 0.0491) and ischemic stroke (OR=0.38, P = 0.0039). They were also associated with the reduced risk for ischemic stroke in the DM patients compared with DM without ischemic stroke (OR=0.25, P = 0.0321). Conclusions : $IL1RN^{\ast}2$ allele could be an accelerating factor, not a predictive marker for ischemic stroke in type 2 DM. The Pro/Ala genotype of $PPAR-{\gamma}2$ Pro12Ala polymorphism may be associated with reduced risk for ischemic stroke with type 2 DM. Therefore it could be a useful predictive marker for ischemic stroke in Korean type 2 DM.

인공판막 치환수술후의 용혈

장원채,이계영,김상형,Jang, Won-Chae,Lee, Gye-Yeong,Kim, Sang-Hyeong 대한흉부심장혈관외과학회 1992 Journal of Chest Surgery (J Chest Surg) Vol.25 No.12

Forty two consecutive patients who had had valve replacement with St. Jude Medical prosthesis were studied on a view point of intravascular hemolysis. Patients were consisted of 14 mitral valve replacement, and 7 aortic valve replacement, and 21 double, mitral and aortic, valve replacement. Serum LDH, indirect bilirubin, GOT, hemoglobin levels and ret-iculocyte count were pursued in postopeative 1st day, 3rd day, 7th day, 14th day and 21th day. Postoperatively, all patients were not detected paravalvular leakage on the ech-ocardiographical study. The patients with double valve replacement revealed higher levels of LDH on postopeative 14th day[P<0 05] than those with single valve replacement. Among the patients with single valve replacement, the patients with aortic valve replacement revealed slightly higher levels of entire postopeative data, but considered insignificant. There was correlation between the severity of hemolysis and the size of replaced aortic valve. In the postoperative LDH levels, the patients with small sized-aortic valve[less than 21mm in diameter] replacement revealed higher levels of postoperative 3rd day, 7th day and 14th day than those with large size[more than 23mm in diameter]. The patients with high level LDH of greater than 800 WU /L on postoperative 7th day were 61.9%[26 of 42]. The high LDH frequency of DVR was 71.4%[15 of 21], MVR 50.0%[7 of 14] and AVR, 57.1%[4 of 7]. The level of LDH declined gradualiy thereafter through postoperative 3 weeks. In conclusion, intravascular hemolysis after prosthetic valve replacement was dependent on position of valve replacement and size of valve. And this study supports the conventional valve selection and usage in our hospital. The patients with subclinical hemolysis after valve replacement should be placed on a close observation.

COLUMN - 축산환경 개선에 관심을

장원경,Jang, Won-Gyeong 한국오리협회 2017 오리마을 Vol.170 No.-

지역재생을 위한 사회적 경제의 의미와 역할

장원봉 국토연구원 2015 국토 : planning and policy Vol.409 No.-

맥락막 출혈에 동반된 황반하 맥락막 순환장애 1예

장원의(Won Ui Chang),고명규(Myung Kyu Ko),김동규(Dong Kyu Kim),윤중훈(Joong Hoon Yoon),이정근(Jung Keun Lee) 대한안과학회 1981 대한안과학회지 Vol.22 No.3

인터넷 사용 환경에서의 조직문화에 관한 연구

장원경,민경호,김태균 대한경영학회 2002 大韓經營學會誌 Vol.15 No.4

The World Wide Web and electronic commerce have grown radically since its inception in 1990 by an average annual growth rate over 100%. The Internet's growth makes the creation of cyber markets and it changes management environments. Information Technology (IT) is the essential element of a firm's development and its survival. The Technology Acceptance Model (TAM) represents an important theoretical contribution toward understanding computer usage and computer acceptance behaviors. The current studies investigated the relationships between organizational tasks and internet using TAM. For using internet, social network is important because the natural characteristic of internet is community-based. However, TAM is incomplete in one important respect: it doesn't account for social influence in the adoption and utilization of new information system. So, organizational culture (OC), that we believe to be important, plays a role in explaining their internet usage. OC will affect user attitude. We extend and empirically validate the TAM for the internet usage including OC. The findings enable future researchers and practitioners to account for social influence in future investigator of TAM. Extending the Technology Acceptance Model to Account for Organizational Culture Won Kyung Changfor the internet usage including OC. The findings enable future researchers and practioners to account for social influence in future investigator of TAM.The World Wide Web and electronic commerce have grown radically since its inception in 1990 by an average annual growth rate over 100%. The Internet's growth makes the creation of cyber markets and it changes management environments. Information Technology (IT) is the essential element of a firm's development and its survival. The Technology Acceptance Model (TAM) represents an important theoretical contribution toward understanding computer usage and computer acceptance behaviors. The current studies investigated the relationships between organizational tasks and internet using TAM. For using internet, social network is important because the natural characteristic of internet is community-based. However, TAM is incomplete in one important respect: it doesn't account for social influence in the adoption and utilization of new information system. So, organizational culture (OC), that we believe to be important, plays a role in explaining their internet usage. OC will affect user attitude. We extend and empirically validate the TAM for the internet usage including OC. The findings enable future researchers and practitioners to account for social influence in future investigator of TAM.

건강도시 거버넌스의 구조와 지향

장원기 순천향대학교 순천향의학연구소 2017 Journal of Soonchunhyang Medical Science Vol.23 No.1

The Healthy Cities program is being actively pursued worldwide under the leadership of the World Health Organization as an effort to improve urban health through changes in the physical and social environment. As the core of the Healthy Cities program, governance establishes and implements diverse health plans and healthy public policies through political support, intersectoral cooperation, community participation, and multilevel networks. With the development of Healthy Cities programs, governance has evolved in the direction of autonomy, equity, and integration. These governance orientations should be continuously reflected in Healthy Cities strategies in order to successfully improve citizens’ health.

[특집] 지역살림운동 - 새로운 살림운동의 전망

장원봉 모심과살림연구소 2016 모심과 살림 Vol.- No.7

Er과 Yb이 동시 도핑된 YCa₄B₃O₁₀의 광 특성

장원권,유영문,Jang, Won-Kweon,Yu, Young-Moon 한국전기전자재료학회 2007 전기전자재료학회논문지 Vol.20 No.12

Optical characteristics of $YCOB(YCa_4B_3O_{10})$, known as a crystal of self frequency doubling, was investigated when Yb and Er ions were co-doped 20 % and 2 %, respectively. The absorption cross section of Er,Yb:YCOB crystal at $1.0\;{\mu}m$ was larger than that of Yb:YCOB, which means that the former was profitable for more energy absorption than the latter. The fluorescent lifetime at $1.5\;{\mu}m$ was measured to be 1.27 ms at room temperature, and lengthened to 1.54 ms and 1.62 ms at low temperatures of 77 K and 6 K, respectively. The line widths of fluorescent spectrum at $1.5\;{\mu}m$ were getting narrower as lowering temperature. However, we didn't observe a temperature dependent peak wavelength shift.

「현장과학교육」 학술지 연구논문 및 교육자료의 동향 분석

장원형,이경건,최민지,안태수,문선영,홍훈기 한국현장과학교육학회 2023 현장과학교육 Vol.17 No.1

본 연구에서는 최근 가파른 변화를 맞이한 학교 과학교육 환경에서 학계의 역할을 확인하고, 향후 현장과학교육 연구가 나아가야 할 방향을 제시하고자 학교현장의 과학교육을 주제로 하는 「현장과학교육」 학술지의 연구 동향을 분석하였다. 이를 위해 지난 15년간 「현장과학교육」에 게재된 연구논문 324건 및 교육자료 23건을 대상으로 주제어 빈도 분석 및 분석 틀을 활용한 질적 분석을 수행하였다. 연구 결과 ‘탐구 및 실험’, ‘장치·프로그램 개발 및 적용’ 관련 주제의 연구가 많이 이루어진 것을 알 수 있었으며, 타 학술지에 비해 초·중등학교 소속의 교사들이 논문을 게재한 경우가 많은 것을 알 수 있었다. 하지만 시기별로 연구방법 및 연구주제의 변화가 큰 것으로 나타났으며, 지구과학 교과 및 초등학교급 대상 연구는 다른 항목에 비해 양적으로 부족한 것으로 나타났다.