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Interleukin - 2 와 Cycolphosphamide 를 이용한 말기암 환자 치료
최승훈(S H Choi),임태숙(T S Lim),김병로(B R Kim),박기일(K L Park),이경식(K D Lee),함경수(K S Hahm),나도선(D S Na),한문희(M H Han) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.4
N/A Application of adoptive immunotherapy has been the inability to generate specifically sensitized lymphoid cells with antitumor reactivity. Interleukin-2 is now available in large quantities and has made possible expansion of cells with a diverse spectrum of immune reactivities. In this study, we evaluated the immunologic effects and the response rate of LAK cell, Interleukin-2 and cyclophosphamide administered intravenously in humans with tumors unresponsive to other treatments. There were five hepatomas and a metastatic breast cnacer. Two patients received LAK cell and Interleukin-2 twice. 5.94x10 monounclear cells were obtained in each leukapheresis. Cellular cytotoxicity was measured using 51 Chromium release assay. This study clearly showed that Interleukin-2 and Cyclophosphamide treatment augmented LAK cell activity, but there were no statistically significant differences in the natural killer cell function after the treatment. There were one complete response and one partial response. It could be speculated that LAK, Interleukin-2 and Cyclophosphamide therapy can be used as an adjuvant treatment for the advanced cancer.